This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Takahashi, H. Articles by Bunag, R. D. Search for Related Content PubMed PubMed Citation Articles by Takahashi, H. Articles by Bunag, R. D.

Hypertension, Vol 2, 198-206, Copyright © 1980 by American Heart Association

ARTICLES

Augmentation of centrally induced alpha-adrenergic vasodepression in spontaneously hypertensive rats

H Takahashi and RD Bunag

Central alpha-adrenergic mechanisms for cardiovascular regulation were studied by injecting phenylephrine into a recipient rat whose head was isolated from its body by cross perfusion with a donor rat. Blood pressure increases produced in the donor were accompanied by concurrent reduction of blood pressure and sympathetic nerve activity in the recipient rat's body. These effects were abolished when alpha- adrenergic receptors in the perfused head were blocked with phentolamine. By contrast, intracarotid injections of angiotensin increased blood pressure not only in donor but also in recipient rats. The magnitude of phenylephrine-induced vasodepression was significantly greater in spontaneously hypertensive rats (SHR) than in normotensive or DOCA-salt hypertensive ones. Distribution of radioactive microspheres indicated that carotid arterial blood went mainly to the cerebrum, midbrain, and hypothalamus, with almost negligible amounts going to the lower brainstem. Collectively, our results suggest that centrally administered phenylephrine reduces sympathetic vasomotor tone and blood pressure by acting on alpha-adrenergic receptors located in supramedullary brain areas (possibly in the hypothalamus). In SHR, augmented, vasodepressor responsiveness may be due to reduced brain levels of endogenous norepinephrine that could increase the alpha- adrenergic receptors available.

This article has been cited by other articles:

				H. E. De Wardener The Hypothalamus and Hypertension Physiol Rev, October 1, 2001; 81(4): 1599 - 1658. [Abstract] [Full Text] [PDF]

				M. Nishimura, H. Takahashi, A. Nanbu, M. Sakamoto, T. Nakanishi, and M. Yoshimura Cerebral ATP-Sensitive Potassium Channels During Acute Reduction of Carotid Blood Flow Hypertension, May 1, 1995; 25(5): 1069 - 1074. [Abstract] [Full Text]