Hypertension, Vol 2, 333-341, Copyright © 1980 by American Heart Association
RD Watson, TJ Stallard, RM Flinn and WA Littler
Intra-arterial pressure was recorded continuously in 26 patients with
uncomplicated essential hypertension under standardized conditions.
Recordings were analyzed beat by beat to obtain mean pressures and
variability, expressed as the standard deviation of the frequency
histogram. The major factors influencing variability were the level of
pressure and the intensity of physical activity; systolic variability
increased with progressive impairment of sino-aortic baroreflexes.
Diastolic pressure increased with the level of sympathetic activity as
reflected by plasma norepinephrine levels. After allowance for the decrease
of plasma renin activity (PRA) with age, direct relationships were observed
between PRA (log values) and the level of pressure and systolic
variability; plasma angiotensin II values did not correlate. Systolic
variability increased with the systolic response to cold but was unrelated
to the response to dynamic or isometric exercise. Variability also tended
to increase with obesity and was unrelated to age, sex, or race.
ARTICLES
Factors determining direct arterial pressure and its variability in hypertensive man
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