Hypertension, Vol 20, 113-117, Copyright © 1992 by American Heart Association
FJ Salazar, JM Pinilla, F Lopez, JC Romero and T Quesada
The aim of the present study was to investigate in conscious dogs the
long-term effects of nitric oxide synthesis inhibition on glomerular
filtration rate, sodium and water excretion, and plasma levels of renin and
aldosterone. After a control period of 3 days, an inhibitor of
endothelium-derived nitric oxide synthesis, NG-nitro-L-arginine-methyl
ester, was infused for 3 consecutive days at a dose (50 ng/kg/min) that did
not induce significant changes in arterial pressure (n = 6). The inhibition
of nitric oxide synthesis led to a large and sustained decrease (p less
than 0.05) in glomerular filtration rate of approximately 35%. This change
was accompanied by a decrease (p less than 0.05) in urinary sodium
excretion from 78.9 +/- 4.6 meq/day to 49.8 +/- 6.8, 60.1 +/- 4.2, and 53.5
+/- 9.0 meq/day by days 1, 2, and 3 of nitric oxide synthesis inhibition,
respectively. Changes in fractional sodium excretion failed to achieve
statistical significance. Nitric oxide synthesis inhibition also induced a
significant and sustained decrease in urine flow rate. The decrease in
glomerular filtration rate, natriuresis, and diuresis was accompanied by a
45% increase in plasma renin activity (p less than 0.05) and no change in
plasma aldosterone concentration. By day 3 of the recovery period,
glomerular filtration rate, natriuresis, diuresis, and plasma renin
activity returned to values similar to those found during the control
period. The administration of L-arginine during 3 consecutive days (5
micrograms/kg.min i.v.) did not modify any of the parameters measured but
effectively prevented all the renal changes induced by the 3 days of nitric
oxide synthesis inhibition.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Renal effects of prolonged synthesis inhibition of endothelium-derived nitric oxide
Department of Physiology, School of Medicine, University of Murcia, Spain.
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