Hypertension, Vol 20, 158-167, Copyright © 1992 by American Heart Association
M Nishimura, A Milsted, CH Block, KB Brosnihan and CM Ferrario
Angiotensinogen messenger RNA (mRNA) levels were measured in the brain
(hypothalamus, lower brain stem, cerebellum), liver, kidneys, and adrenal
glands of rats made hypertensive by ligation of the aorta between the renal
arteries. We also measured renin mRNA in the kidneys of these renal
hypertensive rats. The early phase of hypertension (day 6) was associated
with significant increases in plasma renin activity and levels of
circulating angiotensin II. The circulating renin- angiotensin system was
not activated in the later phase of hypertension (day 24). Angiotensinogen
mRNA levels were elevated in the lower brain stem of hypertensive rats at
both stages of hypertension. In contrast, angiotensinogen mRNA levels in
the hypothalamus were increased only at day 6 after aortic ligation.
Decreased levels of angiotensinogen mRNA were observed in the cerebellum in
both the early and later phases of the hypertension. Angiotensinogen mRNA
levels in the adrenal gland below the ligature fell in the early phases but
rose in the later phases of hypertension. Renin mRNA levels of the ischemic
kidney remained elevated at both the early and later phases, whereas in
both ischemic and nonischemic kidneys, levels of angiotensinogen mRNA
remained below sham values throughout the period of study. These results
indicate differential expression of renin-angiotensin system mRNAs in
tissues of renal hypertensive rats. The differential changes in the
expression of angiotensinogen mRNA over the course of development and
maintenance of renal hypertension suggest that factors in addition to
angiotensin II are important in modulating the expression of
renin-angiotensin system genes.
ARTICLES
Tissue renin-angiotensin systems in renal hypertension
Department of Brain and Vascular Research, Cleveland Clinic Foundation, Ohio 44195.
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