This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Shiota, N. Articles by Okunishi, H. Search for Related Content PubMed PubMed Citation Articles by Shiota, N. Articles by Okunishi, H.

Hypertension, Vol 20, 168-174, Copyright © 1992 by American Heart Association

ARTICLES

Increase of angiotensin converting enzyme gene expression in the hypertensive aorta

N Shiota, M Miyazaki and H Okunishi
Department of Pharmacology, Osaka Medical College, Takatsuki, Japan.

To investigate the possible role of vascular angiotensin converting enzyme (ACE) in the development and maintenance of hypertension, we examined aortic ACE messenger RNA (mRNA) levels in two-kidney, one clip (2K1C) hypertensive rats. The blood pressure was increased remarkably at 4 weeks (early stage) after clipping and remained elevated at 12 weeks (chronic stage). The aorta ACE mRNA levels were significantly elevated in both early and chronic stages concurrently with the increases in aortic ACE activity and blood pressure. The plasma renin activity rose markedly at 4 weeks, but returned to the normal level at 12 weeks. Neither ACE activity in the lung and plasma, nor ACE mRNA level in the lung was altered at either stage. The aorta and liver angiotensinogen mRNA levels and renal renin mRNA level were increased at 4 weeks but decreased at 12 weeks. These results indicate that the acceleration of all components in the renin-angiotensin system may contribute to the development of 2K1C hypertension in the early stage. In the chronic stage, the increased vascular ACE induced by the elevated ACE mRNA levels in the aorta may play the primary role in the acceleration of local angiotensin II formation and thus may sustain the hypertension.

This article has been cited by other articles:

				F. QING, T. J. McCARTHY, J. MARKHAM, and D. P. SCHUSTER Pulmonary Angiotensin-converting Enzyme (ACE) Binding and Inhibition in Humans . A Positron Emission Tomography Study Am. J. Respir. Crit. Care Med., June 1, 2000; 161(6): 2019 - 2025. [Abstract] [Full Text]

				O. Olivieri, E. Trabetti, S. Grazioli, C. Stranieri, S. Friso, D. Girelli, C. Russo, P. F. Pignatti, G. Mansueto, and R. Corrocher Genetic Polymorphisms of the Renin-Angiotensin System and Atheromatous Renal Artery Stenosis Hypertension, November 1, 1999; 34(5): 1097 - 1100. [Abstract] [Full Text] [PDF]

				W. Linz, P. Wohlfart, B. A Scholkens, T. Malinski, and G. Wiemer Interactions among ACE, kinins and NO Cardiovasc Res, August 15, 1999; 43(3): 549 - 561. [Full Text] [PDF]

				K. Tamura, N. Nyui, N. Tamura, T. Fujita, M. Kihara, Y. Toya, I. Takasaki, N. Takagi, M. Ishii, K.-i. Oda, et al. Mechanism of Angiotensin II-mediated Regulation of Fibronectin Gene in Rat Vascular Smooth Muscle Cells J. Biol. Chem., October 9, 1998; 273(41): 26487 - 26496. [Abstract] [Full Text] [PDF]

				E. Villard, A. Alonso, M. Agrapart, M. Challah, and F. Soubrier Induction of Angiotensin I-converting Enzyme Transcription by a Protein Kinase C-dependent Mechanism in Human Endothelial Cells J. Biol. Chem., September 25, 1998; 273(39): 25191 - 25197. [Abstract] [Full Text] [PDF]

				A. Wickman, P. Friberg, M. A. Adams, G. L. Matejka, C. Brantsing, G. Guron, and J. Isgaard Induction of Growth Hormone Receptor and Insulin-Like Growth Factor-I mRNA in Aorta and Caval Vein During Hemodynamic Challenge Hypertension, January 1, 1997; 29(1): 123 - 130. [Abstract] [Full Text]

				K. Tamura, S. Umemura, N. Nyui, T. Yamakawa, S. Yamaguchi, T. Ishigami, S.-i. Tanaka, K. Tanimoto, N. Takagi, H. Sekihara, et al. Tissue-Specific Regulation of Angiotensinogen Gene Expression in Spontaneously Hypertensive Rats Hypertension, June 1, 1996; 27(6): 1216 - 1223. [Abstract] [Full Text]

				F. Pieruzzi, Z. A. Abassi, and H. R. Keiser Expression of Renin-Angiotensin System Components in the Heart, Kidneys, and Lungs of Rats With Experimental Heart Failure Circulation, November 15, 1995; 92(10): 3105 - 3112. [Abstract] [Full Text]

				G. Rossi, A. Rossi, A. Sacchetto, E. Pavan, and A. C. Pessina Hypertensive Cerebrovascular Disease and the Renin-Angiotensin System Stroke, September 1, 1995; 26(9): 1700 - 1706. [Abstract] [Full Text]

				M. G. Melaragno and G. D. Fink Enhanced Slow Pressor Effect of Angiotensin II in Two-Kidney, One Clip Rats Hypertension, February 1, 1995; 25(2): 288 - 293. [Abstract] [Full Text]

				K. Tamura, Y. E. Chen, M. Lopez-Ilasaca, L. Daviet, N. Tamura, T. Ishigami, M. Akishita, I. Takasaki, Y. Tokita, R. E. Pratt, et al. Molecular Mechanism of Fibronectin Gene Activation by Cyclic Stretch in Vascular Smooth Muscle Cells J. Biol. Chem., October 27, 2000; 275(44): 34619 - 34627. [Abstract] [Full Text] [PDF]