Hypertension, Vol 20, 175-180, Copyright © 1992 by American Heart Association
Y Hirooka, T Imaizumi, H Masaki, S Ando, S Harada, M Momohara and A Takeshita
Animal studies suggest that some angiotensin converting enzyme inhibitors
augment endothelium-dependent vasorelaxation. We aimed to determine if
captopril augments endothelium-dependent vasodilation in middle-aged
hypertensive patients. By using strain-gauge plethysmography, forearm
vasodilation evoked with intra-arterial acetylcholine (4, 8, 16, and 24
micrograms/min) or nitroprusside (0.2, 0.4, 0.8, and 1.2 micrograms/min)
was examined before and after captopril administration (25 mg per os).
Before captopril, forearm vasodilation with acetylcholine was less in
hypertensive patients (n = 12) than in age-matched (n = 7) or young (n = 7)
normotensive subjects, but forearm vasodilation with nitroprusside did not
differ among the three groups. Captopril improved forearm vasodilation in
hypertensive patients (n = 7) with acetylcholine but nitroprusside did not.
In contrast, nifedipine (10 mg per os) did not alter forearm vasodilation
with acetylcholine or nitroprusside in hypertensive patients (n = 5). The
decreases in mean blood pressure caused by captopril and nifedipine in
hypertensive subjects were comparable. Captopril did not alter forearm
vasodilation with acetylcholine or nitroprusside in young normotensive
subjects (n = 7). These results suggest that captopril in hypertensive
patients may acutely improve impaired endothelium- dependent forearm
vasodilation that does not result from reduction in blood pressure per se.
ARTICLES
Captopril improves impaired endothelium-dependent vasodilation in hypertensive patients
Research Institute of Angiocardiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
This article has been cited by other articles:
 |
|
 |
|
  Y. Hirooka and K. Sunagawa Akira Takeshita (1940-2009) Hypertension, August 1, 2009; 54(2): 179 - 180. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Feletou and P. M. Vanhoutte Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture) Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H985 - H1002. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Brown, J. A.S. Muldowney III, and D. E. Vaughan Endogenous NO Regulates Plasminogen Activator Inhibitor-1 During Angiotensin-Converting Enzyme Inhibition Hypertension, March 1, 2006; 47(3): 441 - 448. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kishi, Y. Hirooka, A. Masumoto, K. Ito, Y. Kimura, K. Inokuchi, T. Tagawa, H. Shimokawa, A. Takeshita, and K. Sunagawa Rho-Kinase Inhibitor Improves Increased Vascular Resistance and Impaired Vasodilation of the Forearm in Patients With Heart Failure Circulation, May 31, 2005; 111(21): 2741 - 2747. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Sosin, G. S. Bhatia, R. C. Davis, and G. Y.H. Lip Heart failure--the importance of ethnicity Eur J Heart Fail, December 1, 2004; 6(7): 831 - 843. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Sim, C. Farquharson, and A. D Struthers Tonic levels of angiotensin II reduce tonic levels of vascular nitric oxide even in salt-replete man Journal of Renin-Angiotensin-Aldosterone System, June 1, 2004; 5(2): 84 - 88. [Abstract] [PDF]
|
|
|
|
|
|
M. Pretorius, D. Rosenbaum, D. E. Vaughan, and N. J. Brown Angiotensin-Converting Enzyme Inhibition Increases Human Vascular Tissue-Type Plasminogen Activator Release Through Endogenous Bradykinin Circulation, February 4, 2003; 107(4): 579 - 585. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rathaus and J. Bernheim Oxygen species in the microvascular environment: regulation of vascular tone and the development of hypertension Nephrol. Dial. Transplant., February 1, 2002; 17(2): 216 - 221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cardillo, U. Campia, C. M. Kilcoyne, M. B. Bryant, and J. A. Panza Improved Endothelium-Dependent Vasodilation After Blockade of Endothelin Receptors in Patients With Essential Hypertension Circulation, January 29, 2002; 105(4): 452 - 456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Masumoto, Y. Hirooka, H. Shimokawa, K. Hironaga, S. Setoguchi, and A. Takeshita Possible Involvement of Rho-Kinase in the Pathogenesis of Hypertension in Humans Hypertension, December 1, 2001; 38(6): 1307 - 1310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Asberg, K. Midtvedt, T. Vassbotn, and A. Hartmann Better microvascular function on long-term treatment with lisinopril than with nifedipine in renal transplant recipients Nephrol. Dial. Transplant., July 1, 2001; 16(7): 1465 - 1470. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sanada, Y. Higashi, K. Nakagawa, S. Sasaki, I. Kodama, M. Tsuda, N. Nagai, and K. Ohama Relationship between the angiotensin-converting enzyme genotype and the forearm vasodilator response to estrogen replacement therapy in postmenopausal women J. Am. Coll. Cardiol., May 1, 2001; 37(6): 1529 - 1535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. A. van Ampting, M. L. Hijmering, J. J. Beutler, R. E. van Etten, H. A. Koomans, T. J. Rabelink, and E. S. G. Stroes Vascular Effects of ACE Inhibition Independent of the Renin-Angiotensin System in Hypertensive Renovascular Disease : A Randomized, Double-Blind, Crossover Trial Hypertension, January 1, 2001; 37(1): 40 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Sumino, T. Nakamura, T. Kanda, K. Sato, T. Sakamaki, T. Takahashi, Y. Saito, J. Hoshino, T. Kurashina, and R. Nagai Effect of Enalapril on Exhaled Nitric Oxide in Normotensive and Hypertensive Subjects Hypertension, December 1, 2000; 36(6): 934 - 940. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kato, P. Roberts-Thomson, B. G. Phillips, W. G. Haynes, M. Winnicki, V. Accurso, and V. K. Somers Impairment of Endothelium-Dependent Vasodilation of Resistance Vessels in Patients With Obstructive Sleep Apnea Circulation, November 21, 2000; 102(21): 2607 - 2610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cheetham, J. Collis, G. O'Driscoll, K. Stanton, R. Taylor, and D. Green Losartan, an angiotensin type 1 receptor antagonist, improves endothelial function in non-insulin-dependent diabetes J. Am. Coll. Cardiol., November 1, 2000; 36(5): 1461 - 1466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Higashi, S. Sasaki, K. Nakagawa, T. Ueda, A. Yoshimizu, S. Kurisu, H. Matsuura, G. Kajiyama, and T. Oshima A comparison of angiotensin-converting enzyme inhibitors, calcium antagonists, beta-blockers and diuretic agents on reactive hyperemia in patients with essential hypertension: a multicenter study J. Am. Coll. Cardiol., February 1, 2000; 35(2): 284 - 291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. O'Driscoll, D. Green, A. Maiorana, K. Stanton, F. Colreavy, and R. Taylor Improvement in endothelial function by angiotensin-converting enzyme inhibition in non-insulin-dependent diabetes mellitus J. Am. Coll. Cardiol., May 1, 1999; 33(6): 1506 - 1511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cardillo, C. M. Kilcoyne, R. O. Cannon III, and J. A. Panza Attenuation of Cyclic Nucleotide–Mediated Smooth Muscle Relaxation in Blacks as a Cause of Racial Differences in Vasodilator Function Circulation, January 12, 1999; 99(1): 90 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Perticone, R. Ceravolo, R. Maio, G. Ventura, S. Iacopino, G. Cuda, P. Mastroroberto, M. Chello, and P. L. Mattioli Calcium antagonist isradipine improves abnormal endothelium-dependent vasodilation in never treated hypertensive patients Cardiovasc Res, January 1, 1999; 41(1): 299 - 306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cardillo, C. M. Kilcoyne, R. O. Cannon III, and J. A. Panza Impairment of the nitric oxide-mediated vasodilator response to mental stress in hypertensive but not in hypercholesterolemic patients J. Am. Coll. Cardiol., November 1, 1998; 32(5): 1207 - 1213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-T. Dijkhorst-Oei, J. J. Beutler, E. S.G. Stroes, H. A. Koomans, and T. J. Rabelink Divergent effects of ACE-inhibition and calcium channel blockade on NO-activity in systemic and renal circulation in essential hypertension Cardiovasc Res, November 1, 1998; 40(2): 402 - 409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Onaka, K. Fujii, I. Abe, and M. Fujishima Antihypertensive Treatment Improves Endothelium-Dependent Hyperpolarization in the Mesenteric Artery of Spontaneously Hypertensive Rats Circulation, July 14, 1998; 98(2): 175 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Higashi, T. Oshima, S. Sasaki, Y. Nakano, M. Kambe, H. Matsuura, and G. Kajiyama Angiotensin-Converting Enzyme Inhibition, But Not Calcium Antagonism, Improves a Response of the Renal Vasculature to L-Arginine in Patients With Essential Hypertension Hypertension, July 1, 1998; 32(1): 16 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cardillo, C. M. Kilcoyne, R. O. Cannon III, and J. A. Panza Racial Differences in Nitric Oxide–Mediated Vasodilator Response to Mental Stress in the Forearm Circulation Hypertension, June 1, 1998; 31(6): 1235 - 1239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Perticone, R. Ceravolo, R. Maio, G. Ventura, A. Zingone, N. Perrotti, and P. L. Mattioli Angiotensin-Converting Enzyme Gene Polymorphism Is Associated With Endothelium-Dependent Vasodilation in Never Treated Hypertensive Patients Hypertension, April 1, 1998; 31(4): 900 - 905. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cardillo, C. M. Kilcoyne, A. A. Quyyumi, R. O. Cannon III, and J. A. Panza Selective Defect in Nitric Oxide Synthesis May Explain the Impaired Endothelium-Dependent Vasodilation in Patients With Essential Hypertension Circulation, March 10, 1998; 97(9): 851 - 856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. H. Kaasjager, H. A. Koomans, and T. J. Rabelink Endothelin-1–Induced Vasopressor Responses in Essential Hypertension Hypertension, July 1, 1997; 30(1): 15 - 21. [Abstract] [Full Text]
|
|
|
|
|
|
C. Cardillo, C. M. Kilcoyne, R. O. Cannon III, A. A. Quyyumi, and J. A. Panza Xanthine Oxidase Inhibition With Oxypurinol Improves Endothelial Vasodilator Function in Hypercholesterolemic but Not in Hypertensive Patients Hypertension, July 1, 1997; 30(1): 57 - 63. [Abstract] [Full Text]
|
|
|
|
|
|
H. Hayakawa and L. Raij The Link Among Nitric Oxide Synthase Activity, Endothelial Function, and Aortic and Ventricular Hypertrophy in Hypertension Hypertension, January 1, 1997; 29(1): 235 - 241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Iwatsubo, M. Nagano, T. Sakai, K. Kumamoto, R. Morita, J. Higaki, T. Ogihara, and T. Hata Converting Enzyme Inhibitor Improves Forearm Reactive Hyperemia in Essential Hypertension Hypertension, January 1, 1997; 29(1): 286 - 290. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Antony, G. Lerebours, and A. Nitenberg Angiotensin-Converting Enzyme Inhibition Restores Flow-Dependent and Cold Pressor Test–Induced Dilations in Coronary Arteries of Hypertensive Patients Circulation, December 15, 1996; 94(12): 3115 - 3122. [Abstract] [Full Text]
|
|
|
|
|
|
W. Motz and B. E. Strauer Improvement of Coronary Flow Reserve After Long-term Therapy With Enalapril Hypertension, May 1, 1996; 27(5): 1031 - 1038. [Abstract] [Full Text]
|
|
|
|
|
|
W. Kiowski, L. Linder, R. Nuesch, and B. Martina Effects of Cilazapril on Vascular Structure and Function in Essential Hypertension Hypertension, March 1, 1996; 27(3): 371 - 376. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Hirata, H. Hayakawa, M. Kakoki, A. Tojo, E. Suzuki, K. Kimura, A. Goto, K. Kikuchi, T. Nagano, M. Hirobe, et al. Nitric Oxide Release From Kidneys of Hypertensive Rats Treated With Imidapril Hypertension, March 1, 1996; 27(3): 672 - 678. [Abstract] [Full Text]
|
|
|
|
|
|
C. E. Garcia, C. M. Kilcoyne, C. Cardillo, R. O. Cannon III, A. A. Quyyumi, and J. A. Panza Effect of Copper-Zinc Superoxide Dismutase on Endothelium-Dependent Vasodilation in Patients With Essential Hypertension Hypertension, December 1, 1995; 26(6): 863 - 868. [Abstract] [Full Text]
|
|
|
|
|
|
A. F. Dominiczak and D. F. Bohr Nitric Oxide and Its Putative Role in Hypertension Hypertension, June 1, 1995; 25(6): 1202 - 1211. [Full Text]
|
|
|
|
|
|
K. Egashira, S. Suzuki, Y. Hirooka, H. Kai, M. Sugimachi, T. Imaizumi, and A. Takeshita Impaired Endothelium-Dependent Vasodilation of Large Epicardial and Resistance Coronary Arteries in Patients With Essential Hypertension : Different Responses to Acetylcholine and Substance P Hypertension, February 1, 1995; 25(2): 201 - 206. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. R. Cockcroft, P. J. Chowienczyk, N. Benjamin, and J. M. Ritter Preserved Endothelium-Dependent Vasodilatation in Patients with Essential Hypertension N. Engl. J. Med., April 14, 1994; 330(15): 1036 - 1040. [Abstract] [Full Text]
|
|