Hypertension, Vol 20, 280-291, Copyright © 1992 by American Heart Association
S Kim, M Tokuyama, M Hosoi and K Yamamoto
The plasma and adrenal renin-angiotensin system in stroke-prone
spontaneously hypertensive rats (SHRSP) and Wistar-Kyoto (WKY) rats were
examined in animals at 5, 11, 18, and 25 weeks of age. Plasma active renin
was significantly increased in 18- and 25-week-old SHRSP with impaired
renal function, whereas there was no difference in the plasma prorenin
level or renal renin content between the two strains at all ages examined.
Thus, the rate of activation of prorenin seems to be enhanced in the kidney
of SHRSP with malignant hypertension. Adrenal renin contents were
severalfold higher in SHRSP than WKY rats at all ages. However, adrenal
angiotensin peptides were not increased in SHRSP aged 5 and 11 weeks. In
18-week-old SHRSP, adrenal angiotensin II (Ang II) and III (Ang III) levels
were fourfold and 1.8-fold higher, respectively, than in WKY rats,
accompanied by 1.5-fold higher plasma aldosterone. Increased adrenal
angiotensin and plasma aldosterone were also found in 25-week-old SHRSP.
Zonal distribution studies indicated that the elevated Ang II and III in
SHRSP were derived mainly from the capsular tissue (the zona glomerulosa).
To examine the contribution of circulating angiotensin to the adrenal
angiotensin content, effects of bilateral nephrectomy on adrenal
angiotensin and renin were examined in 18-week-old rats. At 24 hours after
nephrectomy, plasma angiotensin, prorenin, and active renin were decreased
to almost negligible concentrations. Conversely, in both adrenal capsular
and decapsular tissues of SHRSP and WKY rats, neither angiotensin nor renin
was significantly decreased after nephrectomy. These results suggest that
the increase in adrenal capsular Ang II contents in SHRSP may be partly due
to an enhanced local production of Ang II.
ARTICLES
Adrenal and circulating renin-angiotensin system in stroke-prone hypertensive rats
Department of Pharmacology, Osaka City University Medical School, Japan.
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