| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Hypertension, Vol 20, 298-303, Copyright © 1992 by American Heart Association
MO Ribeiro, E Antunes, G de Nucci, SM Lovisolo and R Zatz
Recent studies have indicated that acute inhibition of nitric oxide
biosynthesis in the rat promotes arterial hypertension and renal
vasoconstriction. We evaluated the renal and systemic effects of 4-6 weeks
of nitric oxide blockade in Munich-Wistar rats receiving the nitric oxide
inhibitor nitro-L-arginine orally. Age-matched untreated rats were used as
controls. In an additional seven rats, nitric oxide blockade was carried
out in conjunction with oral administration of the novel angiotensin II
antagonist losartan potassium. Tail-cuff pressure rose progressively in
nitro-L-arginine-treated rats, reaching 164 +/- 6 mm Hg at 4-6 weeks,
compared with 108 +/- 3 mm Hg in controls. In rats concomitantly receiving
losartan, tail-cuff pressure reached 125 +/- 6 mm Hg, still elevated
compared with rats receiving losartan alone (98 +/- 3 mm Hg).
Nitro-L-arginine-treated rats presented marked renal vasoconstriction and
hypoperfusion, as well as a 30% fall in glomerular filtration rate and a
39% increase in filtration fraction. Treatment with Losartan normalized
glomerular filtration rate, but not filtration fraction or renal vascular
resistance. Plasma renin activity was elevated after nitro-L-arginine
treatment. Renal histological examination revealed widespread arteriolar
narrowing, focal arteriolar obliteration, and segmental fibrinoid necrosis
in the glomeruli. In a separate group of rats, nitro-L-arginine
administered for 1 week induced hypertension that was partially reversed by
acute L-arginine, but not D-arginine or L-glycine, infusions. We conclude
that chronic nitric oxide blockade may constitute a new model of severe
arterial hypertension.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension
Department of Internal Medicine, University of Sao Paulo School of Medicine, Brazil.
This article has been cited by other articles:
 |
|
 |
|
  F. Helle, C. Jouzel, C. Chadjichristos, S. Placier, M. Flamant, D. Guerrot, H. Francois, J.-C. Dussaule, and C. Chatziantoniou Improvement of renal hemodynamics during hypertension-induced chronic renal disease: role of EGF receptor antagonism Am J Physiol Renal Physiol, July 1, 2009; 297(1): F191 - F199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Francois, N. Makhanova, P. Ruiz, J. Ellison, L. Mao, H. A. Rockman, and T. M. Coffman A role for the thromboxane receptor in L-NAME hypertension Am J Physiol Renal Physiol, October 1, 2008; 295(4): F1096 - F1102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Carlstrom, R. D. Brown, J. Edlund, J. Sallstrom, E. Larsson, T. Teerlink, F. Palm, N. Wahlin, and A. E. G. Persson Role of nitric oxide deficiency in the development of hypertension in hydronephrotic animals Am J Physiol Renal Physiol, February 1, 2008; 294(2): F362 - F370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Mattson, M. R. Dwinell, A. S. Greene, A. E. Kwitek, R. J. Roman, A. W. Cowley Jr., and H. J. Jacob Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats Am J Physiol Renal Physiol, December 1, 2007; 293(6): F1905 - F1914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yamashita, E. Yamamoto, K. Kataoka, T. Nakamura, S. Matsuba, Y. Tokutomi, Y.-F. Dong, H. Ichijo, H. Ogawa, and S. Kim-Mitsuyama Apoptosis Signal-Regulating Kinase-1 Is Involved in Vascular Endothelial and Cardiac Remodeling Caused by Nitric Oxide Deficiency Hypertension, September 1, 2007; 50(3): 519 - 524. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Ramchandra, C. J. Barrett, S.-J. Guild, F. McBryde, and S. C. Malpas Role of renal sympathetic nerve activity in hypertension induced by chronic nitric oxide inhibition Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2007; 292(4): R1479 - R1485. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Toda, K. Ayajiki, and T. Okamura Interaction of Endothelial Nitric Oxide and Angiotensin in the Circulation Pharmacol. Rev., March 1, 2007; 59(1): 54 - 87. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Bai, S. Ye, R. Mortazavi, V. Campese, and N. D. Vaziri Effect of renal injury-induced neurogenic hypertension on NO synthase, caveolin-1, AKt, calmodulin and soluble guanylate cyclase expressions in the kidney Am J Physiol Renal Physiol, March 1, 2007; 292(3): F974 - F980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Vargas, J. M. Moreno, R. Wangensteen, I. Rodriguez-Gomez, and J. Garcia-Estan The endocrine system in chronic nitric oxide deficiency Eur. J. Endocrinol., January 1, 2007; 156(1): 1 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. O'Riordan, N. Mendelev, S. Patschan, D. Patschan, J. Eskander, L. Cohen-Gould, P. Chander, and M. S. Goligorsky Chronic NOS inhibition actuates endothelial-mesenchymal transformation Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H285 - H294. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. Zhao, S. Wang, H. Cheng, M.-z. Zhang, T. Takahashi, A. B. Fogo, M. D. Breyer, and R. C. Harris Endothelial Nitric Oxide Synthase Deficiency Produces Accelerated Nephropathy in Diabetic Mice J. Am. Soc. Nephrol., October 1, 2006; 17(10): 2664 - 2669. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Placier, J.-J. Boffa, J.-C. Dussaule, and C. Chatziantoniou Reversal of renal lesions following interruption of nitric oxide synthesis inhibition in transgenic mice Nephrol. Dial. Transplant., April 1, 2006; 21(4): 881 - 888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Fujihara, C. R. Sena, D. M. A. C. Malheiros, A. L. Mattar, and R. Zatz Short-term nitric oxide inhibition induces progressive nephropathy after regression of initial renal injury Am J Physiol Renal Physiol, March 1, 2006; 290(3): F632 - F640. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Kopkan and D. S.A. Majid Enhanced Superoxide Activity Modulates Renal Function in NO-Deficient Hypertensive Rats Hypertension, March 1, 2006; 47(3): 568 - 572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Mollace, C. Muscoli, E. Masini, S. Cuzzocrea, and D. Salvemini Modulation of Prostaglandin Biosynthesis by Nitric Oxide and Nitric Oxide Donors Pharmacol. Rev., June 1, 2005; 57(2): 217 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kawada, G. Solis, N. Ivey, S. Connors, K. Dennehy, P. Modlinger, R. Hamel, J. T. Kawada, E. Imai, R. Langenbach, et al. Cyclooxygenase-1-Deficient Mice Have High Sleep-to-Wake Blood Pressure Ratios and Renal Vasoconstriction Hypertension, June 1, 2005; 45(6): 1131 - 1138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Mattson, M. P. Kunert, R. J. Roman, H. J. Jacob, and A. W. Cowley Jr. Substitution of chromosome 1 ameliorates L-NAME hypertension and renal disease in the fawn-hooded hypertensive rat Am J Physiol Renal Physiol, May 1, 2005; 288(5): F1015 - F1022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Hohenstein, C. Daniel, A. Wagner, J.-P. Stasch, and C. Hugo Stimulation of soluble guanylyl cyclase inhibits mesangial cell proliferation and matrix accumulation in experimental glomerulonephritis Am J Physiol Renal Physiol, April 1, 2005; 288(4): F685 - F693. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. L. Baumbach, C. D. Sigmund, and F. M. Faraci Structure of Cerebral Arterioles in Mice Deficient in Expression of the Gene for Endothelial Nitric Oxide Synthase Circ. Res., October 15, 2004; 95(8): 822 - 829. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Dupuis, F. Soubrier, I. Brocheriou, S. Raoux, M. Haloui, L. Louedec, J.-B. Michel, and S. Nadaud Profiling of Aortic Smooth Muscle Cell Gene Expression in Response to Chronic Inhibition of Nitric Oxide Synthase in Rats Circulation, August 17, 2004; 110(7): 867 - 873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Graciano, R. d. C. Cavaglieri, H. Delle, W. V. Dominguez, D. E. Casarini, D. M. A. C. Malheiros, and I. L. Noronha Intrarenal Renin-Angiotensin System Is Upregulated in Experimental Model of Progressive Renal Disease Induced by Chronic Inhibition of Nitric Oxide Synthesis J. Am. Soc. Nephrol., July 1, 2004; 15(7): 1805 - 1815. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ito, Y. Hirooka, T. Kishi, Y. Kimura, K. Kaibuchi, H. Shimokawa, and A. Takeshita Rho/Rho-Kinase Pathway in the Brainstem Contributes to Hypertension Caused by Chronic Nitric Oxide Synthase Inhibition Hypertension, February 1, 2004; 43(2): 156 - 162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. CUZZOCREA, E. MAZZON, L. DUGO, R. DI PAOLA, A. P. CAPUTI, and D. SALVEMINI Superoxide: a key player in hypertension FASEB J, January 1, 2004; 18(1): 94 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Fortepiani, M. C. O. Ruiz, F. Passardi, M. D. Bentley, J. Garcia-Estan, E. L. Ritman, and J. C. Romero Effect of losartan on renal microvasculature during chronic inhibition of nitric oxide visualized by micro-CT Am J Physiol Renal Physiol, November 1, 2003; 285(5): F852 - F860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. O. Ogungbade, L. A. Akinsanmi, H. Jiang, and A. O. Oyekan Role of epoxyeicosatrienoic acids in renal functional response to inhibition of NO production in the rat Am J Physiol Renal Physiol, November 1, 2003; 285(5): F955 - F964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ying, M. Flamant, S. Vandermeersch, J.-J. Boffa, C. Chatziantoniou, J.-C. Dussaule, and D. Chansel Renal Effects of Omapatrilat and Captopril in Salt-Loaded, Nitric Oxide-Deficient Rats Hypertension, November 1, 2003; 42(5): 937 - 944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Rodriguez-Gomez, J. Sainz, R. Wangensteen, J. M. Moreno, J. Duarte, A. Osuna, and F. Vargas Increased Pressor Sensitivity to Chronic Nitric Oxide Deficiency in Hyperthyroid Rats Hypertension, August 1, 2003; 42(2): 220 - 225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Toda and T. Okamura The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels Pharmacol. Rev., June 1, 2003; 55(2): 271 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhang, D. Carreras, and A. J. de Bold Discoordinate re-expression of cardiac fetal genes in N{omega}-nitro-L-arginine methyl ester (L-NAME) hypertension Cardiovasc Res, January 1, 2003; 57(1): 158 - 167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Zatz, I. L. Noronha, and C. K. Fujihara Experimental and clinical rationale for use of MMF in nontransplant progressive nephropathies Am J Physiol Renal Physiol, December 1, 2002; 283(6): F1167 - F1175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Li and J. M. Simard Increase in Cx45 Gap Junction Channels in Cerebral Smooth Muscle Cells from SHR Hypertension, December 1, 2002; 40(6): 940 - 946. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Spanagel, S. Siegmund, M. Cowen, K.-C. Schroff, G. Schumann, M. Fiserova, I. Sillaber, S. Wellek, M. Singer, and J. Putzke The Neuronal Nitric Oxide Synthase Gene Is Critically Involved in Neurobehavioral Effects of Alcohol J. Neurosci., October 1, 2002; 22(19): 8676 - 8683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Fujihara, A. L. Mattar, J. M. Vieira Jr, D. M. A. C. Malheiros, I. d. L. Noronha, A. R. R. Goncalves, G. de Nucci, and R. Zatz Evidence for the Existence of Two Distinct Functions for the Inducible NO Synthase in the Rat Kidney: Effect of Aminoguanidine in Rats with 5/6 Ablation J. Am. Soc. Nephrol., September 1, 2002; 13(9): 2278 - 2287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Imai, T. Shindo, K. Maemura, M. Sata, Y. Saito, Y. Kurihara, M. Akishita, J. Osuga, S. Ishibashi, K. Tobe, et al. Resistance to Neointimal Hyperplasia and Fatty Streak Formation in Mice With Adrenomedullin Overexpression Arterioscler Thromb Vasc Biol, August 1, 2002; 22(8): 1310 - 1315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Uhlenius, O. Vuolteenaho, and I. Tikkanen Renin-angiotensin blockade improves renal cGMP production via non-AT2-receptor mediated mechanisms in hypertension-induced by chronic NOS inhibition in rat Journal of Renin-Angiotensin-Aldosterone System, December 1, 2001; 2(4): 233 - 239. [Abstract] [PDF]
|
|
|
|
|
|
V. A. Peotta, E. C. Vasquez, and S. S. Meyrelles Cardiovascular Neural Reflexes in L-NAME-Induced Hypertension in Mice Hypertension, September 1, 2001; 38(3): 555 - 559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kaikita, A. B. Fogo, L. Ma, J. A. Schoenhard, N. J. Brown, and D. E. Vaughan Plasminogen Activator Inhibitor-1 Deficiency Prevents Hypertension and Vascular Fibrosis in Response to Long-term Nitric Oxide Synthase Inhibition Circulation, August 14, 2001; 104(7): 839 - 844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Quiroz, H. Pons, K. L. Gordon, J. Rincon, M. Chavez, G. Parra, J. Herrera-Acosta, D. Gomez-Garre, R. Largo, J. Egido, et al. Mycophenolate mofetil prevents salt-sensitive hypertension resulting from nitric oxide synthesis inhibition Am J Physiol Renal Physiol, July 1, 2001; 281(1): F38 - F47. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Osanai, N. Akutsu, N. Fujita, T. Nakano, K. Takahashi, W. Guan, and K. Okumura Cross talk between prostacyclin and nitric oxide under shear in smooth muscle cell: role in monocyte adhesion Am J Physiol Heart Circ Physiol, July 1, 2001; 281(1): H177 - H182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G.-J. Wang, A. Y.-C. Shum, Y.-L. Lin, J.-F. Liao, X.-C. Wu, J. Ren, and C.-F. Chen Calcium Channel Blockade in Vascular Smooth Muscle Cells: Major Hypotensive Mechanism of S-Petasin, a Hypotensive Sesquiterpene from Petasites formosanus J. Pharmacol. Exp. Ther., April 1, 2001; 297(1): 240 - 246. [Abstract] [Full Text]
|
|
|
|
|
|
H. C. D. Souza, G. Ballejo, M. C. O. Salgado, V. J. Dias Da Silva, and H. C. Salgado Cardiac sympathetic overactivity and decreased baroreflex sensitivity in L-NAME hypertensive rats Am J Physiol Heart Circ Physiol, February 1, 2001; 280(2): H844 - H850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Dobrian, M. J. Davies, S. D. Schriver, T. J. Lauterio, and R. L. Prewitt Oxidative Stress in a Rat Model of Obesity-Induced Hypertension Hypertension, February 1, 2001; 37(2): 554 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Raij Workshop: Hypertension and Cardiovascular Risk Factors : Role of the Angiotensin II-Nitric Oxide Interaction Hypertension, February 1, 2001; 37(2): 767 - 773. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Fujihara, D. M. Avancini Costa Malheiros, I. de Lourdes Noronha, G. De Nucci, and R. Zatz Mycophenolate Mofetil Reduces Renal Injury in the Chronic Nitric Oxide Synthase Inhibition Model Hypertension, January 1, 2001; 37(1): 170 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Arcos, C. K. Fujihara, A. Sesso, E. Brandao De Almeida Prado, M. J. Brandao De Almeida Prado, G. De Nucci, and R. Zatz Mechanisms of albuminuria in the chronic nitric oxide inhibition model Am J Physiol Renal Physiol, December 1, 2000; 279(6): F1060 - F1066. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. DE GRACIA, A. OSUNA, F. O'VALLE, R. G. DEL MORAL, R. WANGENSTEEN, C. G. DEL RIO, and F. VARGAS Deoxycorticosterone Suppresses the Effects of Losartan in Nitric Oxide--Deficient Hypertensive Rats J. Am. Soc. Nephrol., November 1, 2000; 11(11): 1995 - 2000. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. Rocha, C. T. Stier Jr., I. Kifor, M. R. Ochoa-Maya, H. G. Rennke, G. H. Williams, and G. K. Adler Aldosterone: A Mediator of Myocardial Necrosis and Renal Arteriopathy Endocrinology, October 1, 2000; 141(10): 3871 - 3878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. G. Verhagen, D. M. A. Attia, H. A. Koomans, and J. A. Joles Male gender increases sensitivity to proteinuria induced by mild NOS inhibition in rats: role of sex hormones Am J Physiol Renal Physiol, October 1, 2000; 279(4): F664 - F670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Roberts, N. D. Vaziri, X. Q. Wang, and R. J. Barnard Enhanced NO Inactivation and Hypertension Induced by a High-Fat, Refined-Carbohydrate Diet Hypertension, September 1, 2000; 36(3): 423 - 429. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Eshima, Y. Hirooka, H. Shigematsu, I. Matsuo, G. Koike, K. Sakai, and A. Takeshita Angiotensin in the Nucleus Tractus Solitarii Contributes to Neurogenic Hypertension Caused by Chronic Nitric Oxide Synthase Inhibition Hypertension, August 1, 2000; 36(2): 259 - 263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. KASHIWAGI, M. SHINOZAKI, H. HIRAKATA, K. TAMAKI, T. HIRANO, M. TOKUMOTO, H. GOTO, S. OKUDA, and M. FUJISHIMA Locally Activated Renin-Angiotensin System Associated with TGF-{beta}1 as a Major Factor for Renal Injury Induced by Chronic Inhibition of Nitric Oxide Synthase in Rats J. Am. Soc. Nephrol., April 1, 2000; 11(4): 616 - 624. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bartunek, E. O. Weinberg, M. Tajima, S. Rohrbach, S. E. Katz, P. S. Douglas, and B. H. Lorell Chronic NG-Nitro-L-Arginine Methyl Ester-Induced Hypertension : Novel Molecular Adaptation to Systolic Load in Absence of Hypertrophy Circulation, February 1, 2000; 101(4): 423 - 429. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Osanai, N. Fujita, N. Fujiwara, T. Nakano, K. Takahashi, W. Guan, and K. Okumura Cross talk of shear-induced production of prostacyclin and nitric oxide in endothelial cells Am J Physiol Heart Circ Physiol, January 1, 2000; 278(1): H233 - H238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Gardiner, W. R. Dunn, T. Bennett, R. Zatz, and C. Baylis Chronic Nitric Oxide Inhibition Model Six Years On • Response Hypertension, November 1, 1999; e4(5): . [Full Text]
|
|
|
|
|
|
C. T. Bergamaschi, R. R. Campos, and O. U. Lopes Rostral Ventrolateral Medulla : A Source of Sympathetic Activation in Rats Subjected to Long-Term Treatment With L-NAME Hypertension, October 1, 1999; 34(4): 744 - 747. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. A. L. d'Avila, G. Gadonski, J. Fang, P. Dall'Ago, V. L. Albuquerque, L. R. d. A. Peixoto, T. G. Fernandes, and M. C. Irigoyen Exercise Reverses Peripheral Insulin Resistance in Trained L-NAME-Hypertensive Rats Hypertension, October 1, 1999; 34(4): 768 - 772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Riado, A. Zanesco, L. A. Barker, I. M. S. De Luca, E. Antunes, and G. De Nucci Long-Term Nitric Oxide Inhibition and Chronotropic Responses in Rat Isolated Right Atria Hypertension, October 1, 1999; 34(4): 802 - 807. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Rudd, M. Trolliet, S. Hope, A. W. Scribner, G. Daumerie, G. Toolan, T. Cloutier, and J. Loscalzo Salt-induced hypertension in Dahl salt-resistant and salt-sensitive rats with NOS II inhibition Am J Physiol Heart Circ Physiol, August 1, 1999; 277(2): H732 - H739. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-A. Haefliger, P. Meda, A. Formenton, P. Wiesel, A. Zanchi, H. R. Brunner, P. Nicod, and D. Hayoz Aortic Connexin43 Is Decreased During Hypertension Induced by Inhibition of Nitric Oxide Synthase Arterioscler Thromb Vasc Biol, July 1, 1999; 19(7): 1615 - 1622. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kalliovalkama, P. Jolma, J.-P. Tolvanen, M. Kahonen, N. Hutri-Kahonen, X. Wu, P. Holm, and I. Porsti Arterial function in nitric oxide-deficient hypertension: influence of long-term angiotensin II receptor antagonism Cardiovasc Res, June 1, 1999; 42(3): 773 - 782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. FORTEPIANI, E. RODRIGO, M. C. ORTÍZ, V. CACHOFEIRO, N. M. ATUCHA, L. M. RUILOPE, V. LAHERA, and J. GARCÍA-ESTAÑ Pressure Natriuresis in Nitric Oxide-Deficient Hypertensive Rats: Effect of Antihypertensive Treatments J. Am. Soc. Nephrol., January 1, 1999; 10(1): 21 - 27. [Abstract] [Full Text]
|
|
|
|
|
|
A. Kurtz and C. Wagner Role of nitric oxide in the control of renin secretion Am J Physiol Renal Physiol, December 1, 1998; 275(6): F849 - F862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Zatz and C. Baylis Chronic Nitric Oxide Inhibition Model Six Years On Hypertension, December 1, 1998; 32(6): 958 - 964. [Full Text] [PDF]
|
|
|
|
|
|
D. M. Pollock and A. Rekito Hypertensive response to chronic NO synthase inhibition is different in Sprague-Dawley rats from two suppliers Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1998; 275(5): R1719 - R1723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Luvara, M. E. Pueyo, M. Philippe, C. Mandet, F. Savoie, D. Henrion, and J.-B. Michel Chronic Blockade of NO Synthase Activity Induces a Proinflammatory Phenotype in the Arterial Wall : Prevention by Angiotensin II Antagonism Arterioscler Thromb Vasc Biol, September 1, 1998; 18(9): 1408 - 1416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Usui, T. Ichiki, M. Katoh, K. Egashira, and A. Takeshita Regulation of Angiotensin II Receptor Expression by Nitric Oxide in Rat Adrenal Gland Hypertension, September 1, 1998; 32(3): 527 - 533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-C. Huang and R.-Y. Tsai Nitric Oxide Synthesis Inhibition Retards Surgical Reversal of One-Kidney Goldblatt Hypertension in Rats Hypertension, September 1, 1998; 32(3): 534 - 540. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. STOCKAND and S. C. SANSOM Glomerular Mesangial Cells: Electrophysiology and Regulation of Contraction Physiol Rev, July 1, 1998; 78(3): 723 - 744. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ohmachi, W. Toriumi, K. Takashima, and K. Doi Systemic Histopathology of Rats Treated with 6-Sulfanilamidoindazole, a Novel Arthritogenic Sulfonamide Toxicol Pathol, March 1, 1998; 26(2): 262 - 270. [Abstract] [PDF]
|
|
|
|
|
|
C. K. Fujihara, D. M. A. C. Malheiros, J. L. Donato, A. Poli, G. De Nucci, and R. Zatz Nitroflurbiprofen, a new nonsteroidal anti-inflammatory, ameliorates structural injury in the remnant kidney Am J Physiol Renal Physiol, March 1, 1998; 274(3): F573 - F579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Godecke, U. K. M. Decking, Z. Ding, J. Hirchenhain, H.-J. Bidmon, S. Godecke, and J. Schrader Coronary Hemodynamics in Endothelial NO Synthase Knockout Mice Circ. Res., February 9, 1998; 82(2): 186 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Qiu, D. Muchant, W. H. Beierwaltes, L. Racusen, and C. Baylis Evolution of Chronic Nitric Oxide Inhibition Hypertension: Relationship to Renal Function Hypertension, January 1, 1998; 31(1): 21 - 26. [Abstract] [Full Text]
|
|
|
|
|
|
M. Takemoto, K. Egashira, H. Tomita, M. Usui, H. Okamoto, A. Kitabatake, H. Shimokawa, K. Sueishi, and A. Takeshita Chronic Angiotensin-Converting Enzyme Inhibition and Angiotensin II Type 1 Receptor Blockade : Effects on Cardiovascular Remodeling in Rats Induced by the Long-term Blockade of Nitric Oxide Synthesis Hypertension, December 1, 1997; 30(6): 1621 - 1627. [Abstract] [Full Text]
|
|
|
|
|
|
J.-M. Chillon, S. Ghoneim, and G. L. Baumbach Effects of Chronic Nitric Oxide Synthase Inhibition on Cerebral Arterioles in Rats Hypertension, November 1, 1997; 30(5): 1097 - 1104. [Abstract] [Full Text]
|
|
|
|
|
|
L. I. Juncos, J. C. Cornejo, J. Gomes, S. Baigorria, and L. A. Juncos Abnormal Endothelium-Dependent Responses in Early Radiation Nephropathy Hypertension, September 1, 1997; 30(3): 672 - 676. [Abstract] [Full Text]
|
|
|
|
|
|
M. Sander, J. Hansen, and R. G. Victor The Sympathetic Nervous System Is Involved in the Maintenance but Not Initiation of the Hypertension Induced by N{omega}-Nitro-L-Arginine Methyl Ester Hypertension, July 1, 1997; 30(1): 64 - 70. [Abstract] [Full Text]
|
|
|
|
|
|
P. Sventek, A. Turgeon, and E. L. Schiffrin Vascular Endothelin-1 Gene Expression and Effect on Blood Pressure of Chronic ETA Endothelin Receptor Antagonism After Nitric Oxide Synthase Inhibition With L-NAME in Normal Rats Circulation, January 7, 1997; 95(1): 240 - 244. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. G. Shesely, N. Maeda, H.-S. Kim, K. M. Desai, J. H. Krege, V. E. Laubach, P. A. Sherman, W. C. Sessa, and O. Smithies Elevated blood pressures in mice lacking endothelial nitric oxide synthase PNAS, November 12, 1996; 93(23): 13176 - 13181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R. Knoblich, R. H. Freeman, and D. Villarreal Pressure-Dependent Renin Release During Chronic Blockade of Nitric Oxide Synthase Hypertension, November 1, 1996; 28(5): 738 - 742. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Erlich and T. Rosenthal Contribution of Nitric Oxide to the Beneficial Effects of Enalapril in the Fructose-Induced Hyperinsulinemic Rat Hypertension, November 1, 1996; 28(5): 754 - 757. [Abstract] [Full Text]
|
|
|
|
|
|
D. Henrion, F. J. Dowell, B. I. Levy, and J.-B. Michel In Vitro Alteration of Aortic Vascular Reactivity in Hypertension Induced by Chronic NG-Nitro-L-Arginine Methyl Ester Hypertension, September 1, 1996; 28(3): 361 - 366. [Abstract] [Full Text]
|
|
|
|
|
|
M. E. Ullian, D. J. Hazen-Martin, L. G. Walsh, R. K. Davda, and B. M. Egan Carbenoxolone Damages Endothelium and Enhances Vasoconstrictor Action in Aortic Rings Hypertension, June 1, 1996; 27(6): 1346 - 1352. [Abstract] [Full Text]
|
|
|
|
|
|
S. S. Yamada, A. L. Sassaki, C. K. Fujihara, D. M. Avancini Costa Malheiros, G. De Nucci, and R. Zatz Effect of Salt Intake and Inhibitor Dose on Arterial Hypertension and Renal Injury Induced by Chronic Nitric Oxide Blockade Hypertension, May 1, 1996; 27(5): 1165 - 1172. [Abstract] [Full Text]
|
|
|
|
|
|
N. Bouriquet, M. Dupont, A. Herizi, A. Mimran, and D. Casellas Preglomerular Sudanophilia in L-NAME Hypertensive Rats : Involvement of Endothelin Hypertension, March 1, 1996; 27(3): 382 - 391. [Abstract] [Full Text]
|
|
|
|
|
|
H. Ono, Y. Ono, and E. D. Frohlich ACE Inhibition Prevents and Reverses L-NAMEExacerbated Nephrosclerosis in Spontaneously Hypertensive Rats Hypertension, February 1, 1996; 27(2): 176 - 183. [Abstract] [Full Text]
|
|
|
|
|
|
H. Guan, V. Cachofeiro, M. L. Pucci, P. M. Kaminski, M. S. Wolin, and A. Nasjletti Nitric Oxide and the Depressor Response to Angiotensin Blockade in Hypertension Hypertension, January 1, 1996; 27(1): 19 - 24. [Abstract] [Full Text]
|
|
|
|
|
|
H. Takase, P. Moreau, C. F. Kung, E. Nava, and T. F. Luscher Antihypertensive Therapy Prevents Endothelial Dysfunction in Chronic Nitric Oxide Deficiency : Effect of Verapamil and Trandolapril Hypertension, January 1, 1996; 27(1): 25 - 31. [Abstract] [Full Text]
|
|
|
|
|
|
S. Grunfeld, C. A. Hamilton, S. Mesaros, S. W. McClain, A. F. Dominiczak, D. F. Bohr, and T. Malinski Role of Superoxide in the Depressed Nitric Oxide Production by the Endothelium of Genetically Hypertensive Rats Hypertension, December 1, 1995; 26(6): 854 - 857. [Abstract] [Full Text]
|
|
|
|
|
|
K. Numaguchi, K. Egashira, M. Takemoto, T. Kadokami, H. Shimokawa, K. Sueishi, and A. Takeshita Chronic Inhibition of Nitric Oxide Synthesis Causes Coronary Microvascular Remodeling in Rats Hypertension, December 1, 1995; 26(6): 957 - 962. [Abstract] [Full Text]
|
|
|
|
|
|
R. A. Cohen and P. M. Vanhoutte Endothelium-Dependent Hyperpolarization : Beyond Nitric Oxide and Cyclic GMP Circulation, December 1, 1995; 92(11): 3337 - 3349. [Full Text]
|
|
|
|
 |
|
 P. Moreau, H. Takase, C. F. Kung, M.-M. van Rooijen, T. Schaffner, and T. F. Luscher Structure and Function of the Rat Basilar Artery During Chronic Nitric Oxide Synthase Inhibition Stroke, October 1, 1995; 26(10): 1922 - 1929. [Abstract] [Full Text]
|
|
|
|
|
|
E. Delacretaz, A. Zanchi, J. Nussberger, D. Hayoz, J.-F. Aubert, H. R. Brunner, and B. Waeber Chronic Nitric Oxide Synthase Inhibition and Carotid Artery Distensibility in Renal Hypertensive Rats Hypertension, August 1, 1995; 26(2): 332 - 336. [Abstract] [Full Text]
|
|
|
|
|
|
M. O. Ribeiro, E. Antunes, M. N. Muscara, G. De Nucci, and R. Zatz Nifedipine Prevents Renal Injury in Rats With Chronic Nitric Oxide Inhibition Hypertension, July 1, 1995; 26(1): 150 - 155. [Abstract] [Full Text]
|
|
|
|
|
|
A. W. Cowley Jr, D. L. Mattson, S. Lu, and R. J. Roman The Renal Medulla and Hypertension Hypertension, April 1, 1995; 25(4): 663 - 673. [Abstract] [Full Text]
|
|
|
|
|
|
H. Nakamoto, C. M. Ferrario, S. B. Fuller, D. L. Robaczewski, E. Winicov, and R. H. Dean Angiotensin-(1-7) and Nitric Oxide Interaction in Renovascular Hypertension Hypertension, April 1, 1995; 25(4): 796 - 802. [Abstract] [Full Text]
|
|
|
|
|
|
C. Qiu, K. Engels, L. Samsell, and C. Baylis Renal Effects of Acute Amino Acid Infusion in Hypertension Induced by Chronic Nitric Oxide Blockade Hypertension, January 1, 1995; 25(1): 61 - 66. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. J. Spyt, K. L. Blake, P. A. C. Watt, and H. Thurston Inhibition of Endothelium-Dependent Relaxation by Free Hemoglobin in the Human Internal Thoracic Artery Vascular and Endovascular Surgery, January 1, 1994; 28(1): 1 - 6. [Abstract] [PDF]
|
|