Hypertension, Vol 20, 763-767, Copyright © 1992 by American Heart Association
S Guan, J Fox, KD Mitchell and LG Navar
Renal tissue angiotensin I (Ang I) and II (Ang II) content and angiotensin
converting enzyme activity were assessed in both kidneys during initial (7
days) and maintenance (25 days) phases of two-kidney, one clip hypertension
in rats. At 7 and 25 days, systolic arterial pressure was 146 +/- 2 and 170
+/- 7 mm Hg, respectively. After 7 days, Ang I content of clipped kidneys
was 64% and 70% higher (p < 0.001) than in nonclipped and sham-operated
kidneys, respectively, when compared with levels in kidneys from
sham-operated rats. In kidneys harvested 25 days after clipping one renal
artery, Ang I and Ang II contents in clipped kidneys were increased 102%
and 24% (p < 0.01), respectively. Ang II content was also 32% higher in
nonclipped kidneys. Angiotensin converting enzyme activity in nonclipped
kidneys was greater (p < 0.05) than that in either clipped (46% higher)
or sham- operated kidneys (57% higher). Plasma Ang I and Ang II levels were
elevated at 7 days but were not different at 25 days in clipped rats. These
results demonstrate a dissociation between intrarenal and circulating
levels of Ang I and Ang II and suggest that qualitatively different
mechanisms may be responsible for the elevated intrarenal Ang II levels
during the initial and maintenance phases of renal hypertension.
ARTICLES
Angiotensin and angiotensin converting enzyme tissue levels in two- kidney, one clip hypertensive rats
Department of Physiology, Tulane University School of Medicine, New Orleans, La 70112.
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