Hypertension, Vol 21, 22-28, Copyright © 1993 by American Heart Association
JP Chin, AP Gust, PJ Nestel and AM Dart
The effects of dietary supplementation with marine oils on vascular
reactivity in human forearm resistance arteries were studied. Healthy male
adults (six to nine subjects per group) were given either maxEPA capsules
(content: eicosapentaenoic acid, 0.178 g/g; docosahexaenoic acid, 0.116
g/g) at doses of 20, 10, or 5 g/day or placebo capsules at 20 g/day for 28
days. Capsule compliance was confirmed by measurement of platelet membrane
incorporation of n-3 fatty acids. Blood pressure was not affected by either
maxEPA or placebo. The influence of treatment interventions on forearm
vasoconstrictive responses to local infusions of angiotensin II and
norepinephrine was examined using venous occlusion plethysmography before
and after treatment. Responses to both agonists were significantly
suppressed by 20 g/day maxEPA (slopes before and after maxEPA,
respectively: angiotensin II, 3.34 and 0.89; norepinephrine, 0.91 and
0.41). When analyzed as difference in area under the dose-response curves,
the suppressive effects of maxEPA were clearly dose dependent (angiotensin
II: 20 g area reduced by 72%, 10 g by 67%, 5 g by 33%). Similarly,
responses to norepinephrine were dose-dependently suppressed by maxEPA (20
g area reduced by 61%, 10 g by 63%, and 5 g by 33%). Placebo had no effect
on the responses to either constrictor. The responses to both agonists
returned to preoil levels after 2 months' discontinuation of 20 g/day
maxEPA. We conclude that the suppressive effects of marine oils on vascular
reactivity may, in part, contribute to their cardioprotective influence in
humans.
ARTICLES
Marine oils dose-dependently inhibit vasoconstriction of forearm resistance vessels in humans
Alfred and Baker Medical Unit, Baker Medical Research Institute, Prahran, Victoria, Australia.
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