Hypertension, Vol 21, 173-184, Copyright © 1993 by American Heart Association
PJ Admiraal, AH Danser, MS Jong, H Pieterman, FH Derkx and MA Schalekamp
To study regional metabolism and production of angiotensin II, we measured
steady-state plasma levels of 125I-angiotensin I and II and endogenous
angiotensin I and II in the aorta and the antecubital, femoral, renal, and
hepatic veins during systemic infusion of 125I- angiotensin I or II.
Extraction of arterially delivered angiotensin II ranged from 30-50% in the
limbs to 80-100% in the renal and hepatomesenteric vascular beds both in
essential hypertension (n = 13) and in unilateral renal artery stenosis (n
= 7). Across the limbs, 20- 30% of arterially delivered angiotensin I was
converted to angiotensin II in both groups, and there was no arteriovenous
gradient in endogenous angiotensin II. No conversion of arterially
delivered angiotensin I was detected across the renal and hepatomesenteric
beds, and there was net extraction of angiotensin II from the systemic
circulation by these beds. Although regional production of angiotensin I at
tissue sites made a significant contribution to its level in the veins,
little of this locally produced angiotensin I reached the regional veins in
the form of angiotensin II, even in the kidney with artery stenosis, where
the venous levels of locally produced angiotensin I were particularly high.
These results provide no evidence for a source of circulating angiotensin
II other than blood-borne angiotensin I and illustrate the high degree of
compartmentalization of angiotensin I and II production.
ARTICLES
Regional angiotensin II production in essential hypertension and renal artery stenosis
Department of Internal Medicine I, University Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands.
This article has been cited by other articles:
 |
|
 |
|
  H. Kobori, M. Nangaku, L. G. Navar, and A. Nishiyama The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease Pharmacol. Rev., September 1, 2007; 59(3): 251 - 287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H.M. van Esch, B. Tom, V. Dive, W. W. Batenburg, D. Georgiadis, A. Yiotakis, J. M.G. van Gool, R. J.A. de Bruijn, R. de Vries, and A.H. J. Danser Selective Angiotensin-Converting Enzyme C-Domain Inhibition Is Sufficient to Prevent Angiotensin I-Induced Vasoconstriction Hypertension, January 1, 2005; 45(1): 120 - 125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Kramers, S. M. Danilov, J. Deinum, I. V. Balyasnikova, N. Scharenborg, M. Looman, F. Boomsma, M. H. de Keijzer, C. van Duijn, S. Martin, et al. Point Mutation in the Stalk of Angiotensin-Converting Enzyme Causes a Dramatic Increase in Serum Angiotensin-Converting Enzyme But No Cardiovascular Disease Circulation, September 11, 2001; 104(11): 1236 - 1240. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. G. Neri Serneri, M. Boddi, L. Poggesi, I. Simonetti, M. Coppo, M. L. Papa, G. F. Lisi, M. Maccherini, R. Becherini, A. Boncompagni, et al. Activation of cardiac renin-angiotensin system in unstable angina J. Am. Coll. Cardiol., July 1, 2001; 38(1): 49 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Saris, M. A. van Dijk, I. Kroon, M. A. D. H. Schalekamp, and A. H. J. Danser Functional Importance of Angiotensin-Converting Enzyme-Dependent In Situ Angiotensin II Generation in the Human Forearm Hypertension, March 1, 2000; 35(3): 764 - 768. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. MaassenVanDenBrink, R. de Vries, P. R. Saxena, M. A.D.H. Schalekamp, and A.H.J. Danser Vasoconstriction by in situ formed angiotensin II: role of ACE and chymase Cardiovasc Res, November 1, 1999; 44(2): 407 - 415. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. G. N. Serneri, P. A. Modesti, M. Boddi, I. Cecioni, R. Paniccia, M. Coppo, G. Galanti, I. Simonetti, S. Vanni, L. Papa, et al. Cardiac Growth Factors in Human Hypertrophy : Relations With Myocardial Contractility and Wall Stress Circ. Res., July 9, 1999; 85(1): 57 - 67. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. van Kats, A. H. J. Danser, J. R. van Meegen, L. M. A. Sassen, P. D. Verdouw, and M. A. D. H. Schalekamp Angiotensin Production by the Heart : A Quantitative Study in Pigs With the Use of Radiolabeled Angiotensin Infusions Circulation, July 7, 1998; 98(1): 73 - 81. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M.E Krekels, W. Spiering, N. C Schaper, A. J.H.M Houben, and P. W de Leeuw Dissociation between the renal effects of angiotensin I and II in sodium-restricted normal subjects Cardiovasc Res, April 1, 1998; 38(1): 215 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Boddi, L. Poggesi, M. Coppo, N. Zarone, S. Sacchi, C. Tania, and G. G. N. Serneri Human Vascular Renin-Angiotensin System and Its Functional Changes in Relation to Different Sodium Intakes Hypertension, March 1, 1998; 31(3): 836 - 842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. F. Hilgers, E. Bingener, C. Stumpf, D. N. Muller, R. E. Schmieder, and R. Veelken Angiotensinases Restrict Locally Generated Angiotensin II to the Blood Vessel Wall Hypertension, January 1, 1998; 31(1): 368 - 372. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Fitzgerald, K. M. Stevenson, R. G. Evans, and W. P. Anderson Systemic hemodynamic responses to chronic angiotensin II infusion into the renal artery of dogs Am J Physiol Regulatory Integrative Comp Physiol, December 1, 1997; 273(6): R1980 - R1989. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. van Kats, L. M. de Lannoy, A. H. J. Danser, J. R. van Meegen, P. D. Verdouw, and M. A. D. H. Schalekamp Angiotensin II Type 1 (AT1) Receptor–Mediated Accumulation of Angiotensin II in Tissues and Its Intracellular Half-life In Vivo Hypertension, July 1, 1997; 30(1): 42 - 49. [Abstract] [Full Text]
|
|
|
|
|
|
D. N. Muller, J. Bohlender, K. F. Hilgers, D. Dragun, O. Costerousse, J. Menard, and F. C. Luft Vascular Angiotensin-Converting Enzyme Expression Regulates Local Angiotensin II Hypertension, January 1, 1997; 29(1): 98 - 104. [Abstract] [Full Text]
|
|
|
|
|
|
G. G. N. Serneri, M. Boddi, M. Coppo, T. Chechi, N. Zarone, M. Moira, L. Poggesi, M. Margheri, and I. Simonetti Evidence for the Existence of a Functional Cardiac Renin-Angiotensin System in Humans Circulation, October 15, 1996; 94(8): 1886 - 1893. [Abstract] [Full Text]
|
|
|
|
|
|
D. N. Muller, K. F. Hilgers, J. Bohlender, A. Lippoldt, J. Wagner, W. Fischli, D. Ganten, J. F. E. Mann, and F. C. Luft Effects of Human Renin in the Vasculature of Rats Transgenic for Human Angiotensinogen Hypertension, August 1, 1995; 26(2): 272 - 278. [Abstract] [Full Text]
|
|
|
|
|
|
M.-L. Lachurie, M. Azizi, T.-T. Guyene, F. Alhenc-Gelas, and J. Menard Angiotensin-Converting Enzyme Gene Polymorphism Has No Influence on the Circulating Renin-Angiotensin-Aldosterone System or Blood Pressure in Normotensive Subjects Circulation, June 15, 1995; 91(12): 2933 - 2942. [Abstract] [Full Text]
|
|
|
|
|
|
N. D. L. Fisher, D. R. Allan, C. L. Gaboury, and N. K. Hollenberg Intrarenal Angiotensin II Formation in Humans : Evidence From Renin Inhibition Hypertension, May 1, 1995; 25(5): 935 - 939. [Abstract] [Full Text]
|
|
|
|
|
|
D. J. Campbell, P. Rong, A. Kladis, B. Rees, D. Ganten, and S. L. Skinner Angiotensin and Bradykinin Peptides in the TGR(mRen-2)27 Rat Hypertension, May 1, 1995; 25(5): 1014 - 1020. [Abstract] [Full Text]
|
|
|
|
|
|
M. Mai, K. F. Hilgers, J. Wagner, J. F. E. Mann, and H. Geiger Expression of Angiotensin-Converting Enzyme in Renovascular Hypertensive Rat Kidney Hypertension, April 1, 1995; 25(4): 674 - 678. [Abstract] [Full Text]
|
|
|
|
|
|
M. G. Melaragno and G. D. Fink Enhanced Slow Pressor Effect of Angiotensin II in Two-Kidney, One Clip Rats Hypertension, February 1, 1995; 25(2): 288 - 293. [Abstract] [Full Text]
|
|