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Hypertension, Vol 21, 248-252, Copyright © 1993 by American Heart Association
H Ueshima, K Mikawa, S Baba, S Sasaki, H Ozawa, M Tsushima, A Kawaguchi, T Omae, Y Katayama and Y Kayamori
Fifty-four untreated, mildly hypertensive men whose daily alcohol
consumption was > or = 28 ml ethanol and who drank at least 4 times per
week took part in a randomized, controlled crossover trial. The purpose of
the trial was to test the effects of alcohol reduction on blood pressure.
After a 2-week familiarization period, the participants were assigned to
either a reduced alcohol drinking group or a usual drinking group for 3
weeks (experimental period 1). The situation was then reversed for the next
3 weeks (experimental period 2). The participants were requested to limit
their daily alcohol consumption to zero or reduce it as much as possible
for the reduced alcohol consumption period. The self-reported alcohol
consumption was 56.1 +/- 3.6 (SEM) ml/day during the usual alcohol drinking
period and 26.1 +/- 3.0 ml/day during the period of reduced alcohol
consumption. Systolic and diastolic blood pressures in the intervention
group were found by analysis of variance to be significantly lower (2.6-4.8
and 2.2-3.0 mm Hg, respectively) than those in the control group during
experimental period 2 for systolic blood pressure and experimental period 1
for diastolic blood pressure. Significant (3.6 mm Hg) and nonsignificant
(1.9 mm Hg) decreases in systolic and diastolic blood pressure,
respectively, were observed. The method of Hills and Armitage was used,
reducing ethanol in daily alcohol consumption by 28 ml. The lowering effect
of reduced alcohol consumption on blood pressure was independent of changes
in salt consumption, which were estimated by 24-hour urine collection and
body weight.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Effect of reduced alcohol consumption on blood pressure in untreated hypertensive men
Department of Health Science, Shiga University of Medical Science, Japan.
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