Hypertension, Vol 21, 455-460, Copyright © 1993 by American Heart Association
SB Harrap, HR Davidson, JM Connor, F Soubrier, P Corvol, R Fraser, CJ Foy and GC Watt
Phenotypic abnormalities of the renin-angiotensin system have been
associated with the predisposition to high blood pressure. The angiotensin
I converting enzyme (ACE) gene has been implicated as a candidate gene. We
examined the distribution of common alleles of the ACE gene and measured
circulating components of the renin-angiotensin system and urinary sodium
excretion in 170 young Caucasian adults with contrasting genetic
predisposition to high blood pressure. Predisposition was defined on the
basis of personal and parental blood pressure levels by using the four
corners sampling method. Young adults with greatest predisposition who had
high blood pressure and two parents with high blood pressure did not show
any significant difference in the distribution of the markers of the ACE
gene, either as genotype or allele frequencies, when compared with young
adults with least predisposition who had low blood pressure and two parents
with low blood pressure. Offspring with urinary sodium excretion above the
median (143.4 mmol per day) also showed no significant differences in the
distribution of ACE alleles or genotype between groups. Different genotypes
were associated with different average serum ACE concentrations (p <
0.0001), but plasma angiotensin II and aldosterone showed no significant
variation with ACE genotype. These results suggest that in a group of
Caucasians selected from the general population, the ACE gene is not
associated with genetic predisposition to high blood pressure. In this
population common ACE gene allelic markers would not be useful indexes of
susceptibility to hypertension.
ARTICLES
The angiotensin I converting enzyme gene and predisposition to high blood pressure
Medical Research Council Blood Pressure Unit, Western Infirmary, Glasgow, UK.
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