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Hypertension, Vol 21, 498-503, Copyright © 1993 by American Heart Association
AV Ng, R Callister, DG Johnson and DR Seals
Muscle sympathetic nerve activity at rest increases with age in humans. The
respective influences of the aging process per se and gender on this
increase and whether age and gender effects on muscle sympathetic nerve
activity can be identified with plasma norepinephrine concentrations,
however, have not been established. To examine these issues, nine young
women (aged 24 +/- 1 years; mean +/- SEM), eight young men (aged 26 +/- 1
years), seven older women (aged 63 +/- 1 years), and eight older men (aged
66 +/- 1 years) were studied. All were healthy, normotensive (blood
pressure < 140/90 mm Hg), nonobese (< 20% above ideal weight),
unmedicated, nonsmokers engaged in minimal to recreational levels of
chronic physical activity. Arterial blood pressure (manual
sphygmomanometry, brachial artery), heart rate, muscle sympathetic nerve
activity (peroneal microneurography), and antecubital venous plasma
norepinephrine concentrations (radioenzymatic assay) were determined during
quiet supine resting conditions. Body weight was higher in men, but there
were no age-related differences, whereas estimated body fat (sum of
skinfolds) was higher in women and in the older groups (p < 0.05).
Estimated daily energy expenditure, arterial blood pressure, and heart rate
were not different among the groups. Both muscle sympathetic nerve activity
burst frequency and burst incidence at rest were progressively higher in
the young women, young men, older women, and older men (10 +/- 1 versus 18
+/- 2 versus 25 +/- 3 versus 39 +/- 5 bursts/min and 16 +/- 1 versus 30 +/-
4 versus 40 +/- 3 versus 61 +/- 6 bursts/100 heartbeats, respectively; all
p < 0.05 versus each other).(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Age and gender influence muscle sympathetic nerve activity at rest in healthy humans
Department of Exercise and Sport Sciences, School of Health Related Professions and College of Medicine, University of Arizona Health Sciences Center, Tucson.
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T. Laitinen, J. Hartikainen, L. Niskanen, G. Geelen, and E. Lansimies Sympathovagal balance is major determinant of short-term blood pressure variability in healthy subjects Am J Physiol Heart Circ Physiol, April 1, 1999; 276(4): H1245 - H1252. [Abstract] [Full Text] [PDF]
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 B Panayiotou, J Reid, M Fotherby, and P Crome Orthostatic haemodynamic responses in acute stroke Postgrad. Med. J., April 1, 1999; 75(882): 213 - 218. [Abstract] [Full Text]
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H. Tanaka, K. P Davy, and D. R Seals Cardiopulmonary baroreflex inhibition of sympathetic nerve activity is preserved with age in healthy humans J. Physiol., February 15, 1999; 515(1): 249 - 254. [Abstract] [Full Text] [PDF]
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Z.-C. Wen, S.-A. Chen, C.-T. Tai, C.-E. Chiang, C.-W. Chiou, and M.-S. Chang Electrophysiological Mechanisms and Determinants of Vagal Maneuvers for Termination of Paroxysmal Supraventricular Tachycardia Circulation, December 15, 1998; 98(24): 2716 - 2723. [Abstract] [Full Text] [PDF]
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J. C. Marker, W. E. Clutter, and P. E. Cryer Reduced epinephrine clearance and glycemic sensitivity to epinephrine in older individuals Am J Physiol Endocrinol Metab, November 1, 1998; 275(5): E770 - E776. [Abstract] [Full Text] [PDF]
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T. Matsukawa, Y. Sugiyama, T. Watanabe, F. Kobayashi, and T. Mano Gender difference in age-related changes in muscle sympathetic nerve activity in healthy subjects Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1998; 275(5): R1600 - R1604. [Abstract] [Full Text] [PDF]
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K. P. Davy, H. Tanaka, E. A. Andros, J. G. Gerber, and D. R. Seals Influence of age on arterial baroreflex inhibition of sympathetic nerve activity in healthy adult humans Am J Physiol Heart Circ Physiol, November 1, 1998; 275(5): H1768 - H1772. [Abstract] [Full Text] [PDF]
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R. E. Van Pelt, K. P. Davy, E. T. Stevenson, T. M. Wilson, P. P. Jones, C. A. Desouza, and D. R. Seals Smaller differences in total and regional adiposity with age in women who regularly perform endurance exercise Am J Physiol Endocrinol Metab, October 1, 1998; 275(4): E626 - E634. [Abstract] [Full Text] [PDF]
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K. P. Davy, D. R. Seals, and H. Tanaka Augmented Cardiopulmonary and Integrative Sympathetic Baroreflexes but Attenuated Peripheral Vasoconstriction With Age Hypertension, August 1, 1998; 32(2): 298 - 304. [Abstract] [Full Text] [PDF]
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Y. B. Sverrisdóttir, M. Elam, H. Herlitz, B.-A. Bengtsson, and G. Johannsson Intense Sympathetic Nerve Activity in Adults with Hypopituitarism and Untreated Growth Hormone Deficiency J. Clin. Endocrinol. Metab., June 1, 1998; 83(6): 1881 - 1885. [Abstract] [Full Text]
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J. A. Taylor, T. D. Williams, D. R. Seals, and K. P. Davy Low-frequency arterial pressure fluctuations do not reflect sympathetic outflow: gender and age differences Am J Physiol Heart Circ Physiol, April 1, 1998; 274(4): H1194 - H1201. [Abstract] [Full Text] [PDF]
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R. S. Mazzeo, C. Rajkumar, G. Jennings, and M. Esler Norepinephrine spillover at rest and during submaximal exercise in young and old subjects J Appl Physiol, June 1, 1997; 82(6): 1869 - 1874. [Abstract] [Full Text] [PDF]
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M. Hausberg, R. P. Hoffman, V. K. Somers, C. A. Sinkey, A. L. Mark, and E. A. Anderson Contrasting Autonomic and Hemodynamic Effects of Insulin in Healthy Elderly Versus Young Subjects Hypertension, March 1, 1997; 29(3): 700 - 705. [Abstract] [Full Text]
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S. Gudbjornsdottir, P. Lonnroth, Y. B. Sverrisdottir, B. G. Wallin, and M. Elam Sympathetic Nerve Activity and Insulin in Obese Normotensive and Hypertensive Men Hypertension, February 1, 1996; 27(2): 276 - 280. [Abstract] [Full Text]
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J. Alfie, G. D. Waisman, C. R. Galarza, M. I. Magi, F. Vasvari, L. M. Mayorga, and M. I. Camera Relationship Between Systemic Hemodynamics and Ambulatory Blood Pressure Level Are Sex Dependent Hypertension, December 1, 1995; 26(6): 1195 - 1199. [Abstract] [Full Text]
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L. A. Lipsitz, C. M. Connelly, M. Kelley-Gagnon, D. K. Kiely, and R. J. Morin Effects of Chronic Estrogen Replacement Therapy on Beat-to-Beat Blood Pressure Dynamics in Healthy Postmenopausal Women Hypertension, October 1, 1995; 26(4): 711 - 715. [Abstract] [Full Text]
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M. D. Esler, J. M. Thompson, D. M. Kaye, A. G. Turner, G. L. Jennings, H. S. Cox, G. W. Lambert, and D. R. Seals Effects of Aging on the Responsiveness of the Human Cardiac Sympathetic Nerves to Stressors Circulation, January 15, 1995; 91(2): 351 - 358. [Abstract] [Full Text]
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