Hypertension, Vol 21, 667-673, Copyright © 1993 by American Heart Association
H Arndt, CW Smith and DN Granger
Although the etiology of hypertension-related organ damage remains poorly
understood, it has recently been proposed that activated and adherent
leukocytes may contribute to the pathogenesis of progressive organ injury
in hypertension. The objective of this study was to determine whether the
adherence and emigration of leukocytes in microvessels differ between
spontaneously hypertensive and normotensive rats. Leukocyte adherence,
rolling, and emigration as well as vessel diameter and erythrocyte velocity
were monitored in mesenteric venules of age-matched normotensive and
hypertensive rats. Measurements were obtained under baseline conditions and
during superfusion of the mesentery with either platelet activating factor,
leukotriene B4, or NG- nitro-L-arginine-methyl ester, an inhibitor of
nitric oxide synthesis. Tissue-associated myeloperoxidase activity, an
index of the total tissue granulocyte population, was measured in various
tissues of normotensive and hypertensive rats. Systemic arterial pressure
and the circulating polymorphonuclear leukocyte count were elevated in
hypertensive relative to normotensive rats. The number of adherent and
emigrated leukocytes under baseline conditions did not differ between
normotensive and hypertensive rats. Although the nitric oxide synthase
inhibitor caused a similar rise in leukocyte adherence and emigration in
both rat strains, the adhesive interactions elicited by either platelet
activating factor or leukotriene B4 were significantly blunted in
hypertensive relative to normotensive rats. Flow cytometric analysis of
whole-blood samples revealed a lower surface expression of CD11b/CD18 on
leukocytes from hypertensive rats under stimulated conditions.
Myeloperoxidase activity in mesentery and small and large intestine was
low, whereas lung, spleen, and stomach values were high in hypertensive
compared with normotensive rats.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Leukocyte-endothelial cell adhesion in spontaneously hypertensive and normotensive rats
Department of Physiology and Biophysics, Louisiana State University Medical Center, Shreveport 71130.
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