Hypertension, Vol 21, 767-771, Copyright © 1993 by American Heart Association
A Nishi, AC Eklof, AM Bertorello and A Aperia
Dopamine is a natriuretic hormone that acts by inhibiting tubular Na+,
K(+)-ATPase activity by activation of the dopamine-1 receptor (the thick
ascending limb [TAL] of Henle) or by a synergistic effect of dopamine-1 and
dopamine-2 receptors (the proximal tubule). The dopamine- 1 receptor is
coupled to adenylate cyclase. In this article we show that prehypertensive
Dahl salt-sensitive (DS) rats have a blunted natriuretic response to
dopamine determined during euvolemic conditions compared with Dahl
salt-resistant (DR) rats. Furthermore, we have examined the renal tubular
effects of dopamine in DS and DR rats. Basal Na+,K(+)-ATPase activity was
similar in DS and DR rats. In proximal tubule, dopamine (10(-5) M)
inhibited Na+,K(+)-ATPase activity in DR but not in DS rats. The dopamine-2
agonist LY171555 (10(-5) M) together with dibutyryl cyclic AMP (10(-6) M)
inhibited proximal tubule Na+,K(+)- ATPase activity in both DS and DR rats.
LY171555 alone had no effect. In TAL, the dopamine-1 agonist fenoldopam
(10(-5) M) inhibited Na+,K(+)- ATPase activity in DR but not in DS rats.
Dibutyryl cyclic AMP (10(-5) M) inhibited TAL Na+,K(+)-ATPase activity in
both DS and DR rats. In cell suspensions from the cortex and the medulla,
activation of the dopamine-1 receptor significantly increased cyclic AMP
content in DR but not in DS rats. The results indicate that DS rats lack
the capacity to inhibit tubular Na+,K(+)-ATPase activity because of a
defective dopamine-1 receptor adenylate cyclase coupling. This defect may
contribute to the impaired natriuretic capacity in DS rats.
ARTICLES
Dopamine regulation of renal Na+,K(+)-ATPase activity is lacking in Dahl salt-sensitive rats
Department of Pediatrics, St. Goran's Children's Hospital, Karolinska Institutet, Stockholm, Sweden.
This article has been cited by other articles:
 |
|
 |
|
  M. Asghar, G. Chugh, and M. F. Lokhandwala Inflammation compromises renal dopamine D1 receptor function in rats Am J Physiol Renal Physiol, December 1, 2009; 297(6): F1543 - F1549. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Gildea, J. A. Israel, A. K. Johnson, J. Zhang, P. A. Jose, and R. A. Felder Caveolin-1 and Dopamine-Mediated Internalization of NaKATPase in Human Renal Proximal Tubule Cells Hypertension, November 1, 2009; 54(5): 1070 - 1076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Banday and M. F. Lokhandwala Inhibition of natriuretic factors increases blood pressure in rats Am J Physiol Renal Physiol, August 1, 2009; 297(2): F397 - F402. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Zeng, I. Armando, Y. Luo, G. M. Eisner, R. A. Felder, and P. A. Jose Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H551 - H569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Banday, Y.-S. Lau, and M. F. Lokhandwala Oxidative Stress Causes Renal Dopamine D1 Receptor Dysfunction and Salt-Sensitive Hypertension in Sprague-Dawley Rats Hypertension, February 1, 2008; 51(2): 367 - 375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Banday and M. F. Lokhandwala Oxidative stress reduces renal dopamine D1 receptor-Gq/11{alpha} G protein-phospholipase C signaling involving G protein-coupled receptor kinase 2 Am J Physiol Renal Physiol, July 1, 2007; 293(1): F306 - F315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Banday, F. R. Fazili, and M. F. Lokhandwala Oxidative Stress Causes Renal Dopamine D1 Receptor Dysfunction and Hypertension via Mechanisms That Involve Nuclear Factor-{kappa}B and Protein Kinase C J. Am. Soc. Nephrol., May 1, 2007; 18(5): 1446 - 1457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Sanada, J. Yatabe, S. Midorikawa, T. Katoh, S. Hashimoto, T. Watanabe, J. Xu, Y. Luo, X. Wang, C. Zeng, et al. Amelioration of Genetic Hypertension by Suppression of Renal G Protein-Coupled Receptor Kinase Type 4 Expression Hypertension, June 1, 2006; 47(6): 1131 - 1139. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Meneton, X. Jeunemaitre, H. E. de Wardener, and G. A. Macgregor Links Between Dietary Salt Intake, Renal Salt Handling, Blood Pressure, and Cardiovascular Diseases Physiol Rev, April 1, 2005; 85(2): 679 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Garrett, H. Meng, J. P. Rapp, and B. Joe Locating a Blood Pressure Quantitative Trait Locus Within 117 kb on the Rat Genome: Substitution Mapping and Renal Expression Analysis Hypertension, March 1, 2005; 45(3): 451 - 459. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Efendiev, R. T. Krmar, G. Ogimoto, J. Zwiller, G. Tripodi, A. I. Katz, G. Bianchi, C. H. Pedemonte, and A. M. Bertorello Hypertension-Linked Mutation in the Adducin {alpha}-Subunit Leads to Higher AP2-{micro}2 Phosphorylation and Impaired Na+,K+-ATPase Trafficking in Response to GPCR Signals and Intracellular Sodium Circ. Res., November 26, 2004; 95(11): 1100 - 1108. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Zeng, H. Sanada, H. Watanabe, G. M. Eisner, R. A. Felder, and P. A. Jose Functional genomics of the dopaminergic system in hypertension Physiol Genomics, November 17, 2004; 19(3): 233 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hussain and M. F. Lokhandwala Renal Dopamine Receptors and Hypertension Experimental Biology and Medicine, February 1, 2003; 228(2): 134 - 142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Felder, H. Sanada, J. Xu, P.-Y. Yu, Z. Wang, H. Watanabe, L. D. Asico, W. Wang, S. Zheng, I. Yamaguchi, et al. G protein-coupled receptor kinase 4 gene variants in human essential hypertension PNAS, March 19, 2002; 99(6): 3872 - 3877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Carey Renal Dopamine System: Paracrine Regulator of Sodium Homeostasis and Blood Pressure Hypertension, September 1, 2001; 38(3): 297 - 302. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. ZICHA, C. D. NEGRIN, Z. DOBESOVA, F. CARR, M. VOKURKOVA, M. W. MCBRIDE, J. KUNES, and A. F. DOMINICZAK Altered Na+-K+ pump activity and plasma lipids in salt-hypertensive Dahl rats: relationship to Atp1a1 gene Physiol Genomics, July 17, 2001; 6(2): 99 - 104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. X. Li, J. Xu, S. Zheng, F. E. Albrecht, J. E. Robillard, G. M. Eisner, and P. A. Jose D1 dopamine receptor regulation of NHE3 during development in spontaneously hypertensive rats Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2001; 280(6): R1650 - R1656. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Yu, L. D. Asico, G. M. Eisner, U. Hopfer, R. A. Felder, and P. A. Jose Renal Protein Phosphatase 2A Activity and Spontaneous Hypertension in Rats Hypertension, December 1, 2000; 36(6): 1053 - 1058. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Therien and R. Blostein Mechanisms of sodium pump regulation Am J Physiol Cell Physiol, September 1, 2000; 279(3): C541 - C566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Xu, X. X. Li, F. E. Albrecht, U. Hopfer, R. M. Carey, and P. A. Jose Dopamine1 Receptor, Gs{alpha}, and Na+-H+ Exchanger Interactions in the Kidney in Hypertension Hypertension, September 1, 2000; 36(3): 395 - 399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Li, R. Belusa, S. Nowicki, and A. Aperia Arachidonic acid metabolic pathways regulating activity of renal Na+-K+-ATPase are age dependent Am J Physiol Renal Physiol, May 1, 2000; 278(5): F823 - F829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zicha and J. Kunes Ontogenetic Aspects of Hypertension Development: Analysis in the Rat Physiol Rev, October 1, 1999; 79(4): 1227 - 1282. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tanahashi, S. Hara, M. Yoshida, M. Suzuki-Kusaba, H. Hisa, and S. Satoh Effects of Rolipram and Cilostamide on Renal Functions and Cyclic AMP Release in Anesthetized Dogs J. Pharmacol. Exp. Ther., June 1, 1999; 289(3): 1533 - 1538. [Abstract] [Full Text]
|
|
|
|
|
|
H. Sanada, P. A. Jose, D. Hazen-Martin, P.-Y. Yu, J. Xu, D. E. Bruns, J. Phipps, R. M. Carey, and R. A. Felder Dopamine-1 Receptor Coupling Defect in Renal Proximal Tubule Cells in Hypertension Hypertension, April 1, 1999; 33(4): 1036 - 1042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hussain and M. F. Lokhandwala Renal Dopamine Receptor Function in Hypertension Hypertension, August 1, 1998; 32(2): 187 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Holtback, Y. Ohtomo, P. Forberg, B. Sahlgren, and A. Aperia Neuropeptide Y shifts equilibrium between alpha - and beta -adrenergic tonus in proximal tubule cells Am J Physiol Renal Physiol, July 1, 1998; 275(1): F1 - F7. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Brismar, M. Asghar, R. M. Carey, P. Greengard, and A. Aperia Dopamine-induced recruitment of dopamine D1 receptors to the plasma membrane PNAS, May 12, 1998; 95(10): 5573 - 5578. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. Chibalin, J. R. Zierath, A. I. Katz, P.-O. Berggren, and A. M. Bertorello Phosphatidylinositol 3-Kinase-mediated Endocytosis of Renal Na+,K+-ATPase alpha Subunit in Response to Dopamine Mol. Biol. Cell, May 1, 1998; 9(5): 1209 - 1220. [Abstract] [Full Text]
|
|
|
|
|
|
C. MISSALE, S. R. NASH, S. W. ROBINSON, M. JABER, and M. G. CARON Dopamine Receptors: From Structure to Function Physiol Rev, January 1, 1998; 78(1): 189 - 225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. O'Connell, N. V. Ragsdale, D. G. Boyd, R. A. Felder, and R. M. Carey Differential Human Renal Tubular Responses to Dopamine Type 1 Receptor Stimulation Are Determined by Blood Pressure Status Hypertension, January 1, 1997; 29(1): 115 - 122. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. C. Hu, L. Fan, L. A. Crowder, Z. Karim-Jimenez, H. Murer, and O. W. Moe Dopamine Acutely Stimulates Na+/H+ Exchanger (NHE3) Endocytosis via Clathrin-coated Vesicles. DEPENDENCE ON PROTEIN KINASE A-MEDIATED NHE3 PHOSPHORYLATION J. Biol. Chem., July 13, 2001; 276(29): 26906 - 26915. [Abstract] [Full Text] [PDF]
|
|