Hypertension, Vol 21, 916-920, Copyright © 1993 by American Heart Association
R Lariviere, R Day and EL Schiffrin
We have recently shown that the content of immunoreactive endothelin-1 is
increased in acid extracts from blood vessels of deoxycorticosterone
acetate (DOCA)-salt hypertensive rats compared with uninephrectomized
control rats. We have also found by immunohistochemistry a significant
increase in immunoreactive endothelin-1 in endothelial cells of aorta and
mesenteric arteries of DOCA-salt hypertensive rats. In the present study,
we investigated preproendothelin-1 gene expression in blood vessels of
DOCA-salt hypertensive rats and uninephrectomized control rats. Northern
blot analysis using a specific 32P-labeled complementary RNA probe for rat
preproendothelin-1 of 319 base pairs revealed a fourfold to fivefold
increase in abundance of preproendothelin-1 messenger RNA transcripts in
both aorta and mesenteric arteries from DOCA-salt hypertensive rats. Thus,
increased immunoreactive endothelin- 1 content in blood vessels of
DOCA-salt hypertensive rats is secondary to increased preproendothelin-1
gene expression. Exaggerated expression of the preproendothelin-1 gene in
mineralocorticoid hypertension may contribute to the maintenance of
elevated blood pressure.
ARTICLES
Increased expression of endothelin-1 gene in blood vessels of deoxycorticosterone acetate-salt hypertensive rats
Medical Research Council Multidisciplinary Research Group on Hypertension, University of Montreal Canada.
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