Hypertension, Vol 21, 929-933, Copyright © 1993 by American Heart Association
S Taddei, A Virdis, P Mattei and A Salvetti
Endothelium-dependent vasodilatation to acetylcholine is reduced in the
forearm of essential hypertensive patients. To investigate whether
endothelium-dependent vasodilatation is reduced also in secondary
hypertension, we evaluated the effects of an intrabrachial infusion of
acetylcholine on forearm blood flow (strain-gauge venous plethysmography)
in essential hypertensive (n = 12), primary aldosteronism hypertensive (n =
8), and renovascular hypertensive (n = 8) patients and normotensive control
subjects (n = 12). To further evaluate the role of a
cyclooxygenase-dependent endothelium-derived vasoconstrictor substance, we
repeated the infusion of acetylcholine in the presence of indomethacin. The
effect of the direct vasodilator sodium nitroprusside was also examined.
The vasodilatation to acetylcholine was reduced in essential, primary
aldosteronism, and renovascular hypertensive patients compared with
normotensive subjects. In contrast, the vasodilatation induced by sodium
nitroprusside was similar in all groups of patients and control subjects.
In the presence of indomethacin, the vasodilator effect of acetylcholine
was increased in essential hypertensive patients but not in normotensive or
in secondary hypertensive individuals. These data demonstrate an impairment
of endothelium-dependent vasodilation in renovascular and primary
aldosteronism hypertensive patients and indicate that a
cyclooxygenase-dependent vasoconstrictor mechanism participates in the
blunting of endothelium-dependent vasodilation in essential hypertensive
patients.
ARTICLES
Vasodilation to acetylcholine in primary and secondary forms of human hypertension
I Clinica Medica, University of Pisa, Italy.
This article has been cited by other articles:
 |
|
 |
|
  M. A. Black, N. T. Cable, D. H. J. Thijssen, and D. J. Green Impact of age, sex, and exercise on brachial artery flow-mediated dilatation Am J Physiol Heart Circ Physiol, September 1, 2009; 297(3): H1109 - H1116. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Wang, S. Strandgaard, J. Iversen, and C. S. Wilcox Asymmetric dimethylarginine, oxidative stress, and vascular nitric oxide synthase in essential hypertension Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2009; 296(2): R195 - R200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hirao, K. Kondo, K. Takeuchi, N. Inui, K. Umemura, K. Ohashi, and H. Watanabe Cyclooxygenase-dependent vasoconstricting factor(s) in remodelled rat femoral arteries Cardiovasc Res, July 1, 2008; 79(1): 161 - 168. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Ghiadoni, G. Penno, C. Giannarelli, Y. Plantinga, M. Bernardini, L. Pucci, R. Miccoli, S. Taddei, A. Salvetti, and S. Del Prato Metabolic Syndrome and Vascular Alterations in Normotensive Subjects at Risk of Diabetes Mellitus Hypertension, February 1, 2008; 51(2): 440 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Brown Aldosterone and Vascular Inflammation Hypertension, February 1, 2008; 51(2): 161 - 167. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Catena, G. Colussi, E. Nadalini, A. Chiuch, S. Baroselli, R. Lapenna, and L. A. Sechi Cardiovascular Outcomes in Patients With Primary Aldosteronism After Treatment Arch Intern Med, January 14, 2008; 168(1): 80 - 85. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-E. Gendron and E. Thorin A change in the redox environment and thromboxane A2 production precede endothelial dysfunction in mice Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2508 - H2515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Barac, U. Campia, and J. A. Panza Methods for Evaluating Endothelial Function in Humans Hypertension, April 1, 2007; 49(4): 748 - 760. [Full Text] [PDF]
|
|
|
|
|
|
I. Sudano, A. Virdis, S. Taddei, L. Spieker, R. Corti, G. Noll, A. Salvetti, and T. F. Luscher Chronic Treatment With Long-Acting Nifedipine Reduces Vasoconstriction to Endothelin-1 in Essential Hypertension Hypertension, February 1, 2007; 49(2): 285 - 290. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Taddei, N. Caraccio, A. Virdis, A. Dardano, D. Versari, L. Ghiadoni, E. Ferrannini, A. Salvetti, and F. Monzani Low-Grade Systemic Inflammation Causes Endothelial Dysfunction in Patients with Hashimoto's Thyroiditis J. Clin. Endocrinol. Metab., December 1, 2006; 91(12): 5076 - 5082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Feletou and P. M. Vanhoutte Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture) Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H985 - H1002. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Taddei, D. Versari, A. Cipriano, L. Ghiadoni, F. Galetta, F. Franzoni, A. Magagna, A. Virdis, and A. Salvetti Identification of a Cytochrome P450 2C9-Derived Endothelium-Derived Hyperpolarizing Factor in Essential Hypertensive Patients J. Am. Coll. Cardiol., August 1, 2006; 48(3): 508 - 515. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Perez-Rojas, S. Derive, J. A. Blanco, C. Cruz, L. M. de la Maza, G. Gamba, and N. A. Bobadilla Renocortical mRNA expression of vasoactive factors during spironolactone protective effect in chronic cyclosporine nephrotoxicity Am J Physiol Renal Physiol, November 1, 2005; 289(5): F1020 - F1030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Funder Relative Aldosterone Excess: Relative to What? Hypertension, October 1, 2005; 46(4): 643 - 644. [Full Text] [PDF]
|
|
|
|
|
|
S. J. Duffy, E. S. Biegelsen, R. T. Eberhardt, D. F. Kahn, B. A. Kingwell, and J. A. Vita Low-Renin Hypertension With Relative Aldosterone Excess Is Associated With Impaired NO-Mediated Vasodilation Hypertension, October 1, 2005; 46(4): 707 - 713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Perticone, A. Sciacqua, R. Maio, M. Perticone, R. Maas, R. H. Boger, G. Tripepi, G. Sesti, and C. Zoccali Asymmetric Dimethylarginine, L-Arginine, and Endothelial Dysfunction in Essential Hypertension J. Am. Coll. Cardiol., August 2, 2005; 46(3): 518 - 523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M C Connell and E. Davies The new biology of aldosterone J. Endocrinol., July 1, 2005; 186(1): 1 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. G. Schrage, N. M. Dietz, J. H. Eisenach, and M. J. Joyner Agonist-dependent variablity of contributions of nitric oxide and prostaglandins in human skeletal muscle J Appl Physiol, April 1, 2005; 98(4): 1251 - 1257. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Racasan, B. Braam, H. A. Koomans, and J. A. Joles Programming blood pressure in adult SHR by shifting perinatal balance of NO and reactive oxygen species toward NO: the inverted Barker phenomenon Am J Physiol Renal Physiol, April 1, 2005; 288(4): F626 - F636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A.S. Muldowney III, S. N. Davis, D. E. Vaughan, and N. J. Brown NO Synthase Inhibition Increases Aldosterone in Humans Hypertension, November 1, 2004; 44(5): 739 - 745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Perticone, R. Maio, G. Tripepi, and C. Zoccali Endothelial Dysfunction and Mild Renal Insufficiency in Essential Hypertension Circulation, August 17, 2004; 110(7): 821 - 825. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Nishizaka, M. A. Zaman, S. A. Green, K. Y. Renfroe, and D. A. Calhoun Impaired Endothelium-Dependent Flow-Mediated Vasodilation in Hypertensive Subjects With Hyperaldosteronism Circulation, June 15, 2004; 109(23): 2857 - 2861. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Sierra and L. M Ruilope Review: Role of the selective aldosterone receptor blockers in arterial hypertension Journal of Renin-Angiotensin-Aldosterone System, March 1, 2004; 5(1): 23 - 25. [Abstract] [PDF]
|
|
|
|
 |
|
 S. CUZZOCREA, E. MAZZON, L. DUGO, R. DI PAOLA, A. P. CAPUTI, and D. SALVEMINI Superoxide: a key player in hypertension FASEB J, January 1, 2004; 18(1): 94 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. T Weber, Yao Sun, L. A Wodi, A. Munir, E. Jahangir, R. A Ahokas, I. C Gerling, A. E Postlethwaite, and K. J Warrington Toward a broader understanding of aldosterone in congestive heart failure Journal of Renin-Angiotensin-Aldosterone System, September 1, 2003; 4(3): 155 - 163. [Abstract] [PDF]
|
|
|
|
 |
|
 P. N. Chander, R. Rocha, J. Ranaudo, G. Singh, A. Zuckerman, and C. T. Stier Jr. Aldosterone Plays a Pivotal Role in the Pathogenesis of Thrombotic Microangiopathy in SHRSP J. Am. Soc. Nephrol., August 1, 2003; 14(8): 1990 - 1997. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. W. Flitney and I. L Megson Nitric Oxide and the Mechanism of Rat Vascular Smooth Muscle Photorelaxation J. Physiol., August 1, 2003; 550(3): 819 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ghiadoni, A. Magagna, D. Versari, I. Kardasz, Y. Huang, S. Taddei, and A. Salvetti Different Effect of Antihypertensive Drugs on Conduit Artery Endothelial Function Hypertension, June 1, 2003; 41(6): 1281 - 1286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Brown Eplerenone: Cardiovascular Protection Circulation, May 20, 2003; 107(19): 2512 - 2518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Belhassen, G. Pelle, J.-L. Dubois-Rande, and S. Adnot Improved endothelial function by the thromboxane a2 receptor antagonist s 18886 in patients with coronary artery disease treated with aspirin J. Am. Coll. Cardiol., April 2, 2003; 41(7): 1198 - 1204. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Taddei, A. Virdis, L. Ghiadoni, D. Versari, G. Salvetti, A. Magagna, and A. Salvetti Calcium Antagonist Treatment by Lercanidipine Prevents Hyperpolarization in Essential Hypertension Hypertension, April 1, 2003; 41(4): 950 - 955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ulker, P. P. McKeown, and U. Bayraktutan Vitamins Reverse Endothelial Dysfunction Through Regulation of eNOS and NAD(P)H Oxidase Activities Hypertension, March 1, 2003; 41(3): 534 - 539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Torrens, L. Brawley, A. C Barker, S. Itoh, L. Poston, and M. A Hanson Maternal protein restriction in the rat impairs resistance artery but not conduit artery function in pregnant offspring J. Physiol., February 15, 2003; 547(1): 77 - 84. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Enseleit, T.F. Luscher, and F. Ruschitzka Angiotensin-converting enzyme inhibition and endothelial dysfunction: focus on ramipril Eur. Heart J. Suppl., January 1, 2003; 5(suppl_A): A31 - A36. [Abstract] [PDF]
|
|
|
|
|
|
G. Jackson and F. Giuliano Moderators' introduction Eur. Heart J. Suppl., December 1, 2002; 4(suppl_H): H1 - H6. [Abstract] [PDF]
|
|
|
|
 |
|
 Y. Sun, J. Zhang, L. Lu, S. S. Chen, M. T. Quinn, and K. T. Weber Aldosterone-Induced Inflammation in the Rat Heart : Role of Oxidative Stress Am. J. Pathol., November 1, 2002; 161(5): 1773 - 1781. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Virdis, M. F. Neves, F. Amiri, E. Viel, R. M. Touyz, and E. L. Schiffrin Spironolactone Improves Angiotensin-Induced Vascular Changes and Oxidative Stress Hypertension, October 1, 2002; 40(4): 504 - 510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Davies and A. Struthers Review: The potential benefits of aldosterone antagonism in Type 2 diabetes mellitus Journal of Renin-Angiotensin-Aldosterone System, September 1, 2002; 3(3): 150 - 155. [Abstract] [PDF]
|
|
|
|
|
|
J. Molnar, M. J. M. Nijland, D. C. Howe, and P. W. Nathanielsz Evidence for microvascular dysfunction after prenatal dexamethasone at 0.7, 0.75, and 0.8 gestation in sheep Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2002; 283(3): R561 - R567. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Tzemos, P.O. Lim, and T.M. MacDonald Is exercise blood pressure a marker of vascular endothelial function? QJM, July 1, 2002; 95(7): 423 - 429. [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Higashi, S. Sasaki, K. Nakagawa, H. Matsuura, T. Oshima, and K. Chayama Endothelial Function and Oxidative Stress in Renovascular Hypertension N. Engl. J. Med., June 20, 2002; 346(25): 1954 - 1962. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rathaus and J. Bernheim Oxygen species in the microvascular environment: regulation of vascular tone and the development of hypertension Nephrol. Dial. Transplant., February 1, 2002; 17(2): 216 - 221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hurlimann, F. Ruschitzka, and T.F. Luscher The relationship between the endothelium and the vessel wall Eur. Heart J. Suppl., February 1, 2002; 4(suppl_A): A1 - A7. [Abstract] [PDF]
|
|
|
|
|
|
Y. Higashi, S. Sasaki, K. Nakagawa, M. Kimura, S. Sasaki, K. Noma, H. Matsuura, K. Hara, C. Goto, T. Oshima, et al. Excess Norepinephrine Impairs Both Endothelium-Dependent and -Independent Vasodilation in Patients With Pheochromocytoma Hypertension, February 1, 2002; 39(2): 513 - 518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cardillo, U. Campia, C. M. Kilcoyne, M. B. Bryant, and J. A. Panza Improved Endothelium-Dependent Vasodilation After Blockade of Endothelin Receptors in Patients With Essential Hypertension Circulation, January 29, 2002; 105(4): 452 - 456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Joyner, N. M. Dietz, and J. T. Shepherd From Belfast to Mayo and beyond: the use and future of plethysmography to study blood flow in human limbs J Appl Physiol, December 1, 2001; 91(6): 2431 - 2441. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Ngarmukos and R. J. Grekin Nontraditional aspects of aldosterone physiology Am J Physiol Endocrinol Metab, December 1, 2001; 281(6): E1122 - E1127. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. T. Davidge Prostaglandin H Synthase and Vascular Function Circ. Res., October 12, 2001; 89(8): 650 - 660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Taddei, A. Virdis, L. Ghiadoni, G. Salvetti, G. Bernini, A. Magagna, and A. Salvetti Age-Related Reduction of NO Availability and Oxidative Stress in Humans Hypertension, August 1, 2001; 38(2): 274 - 279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Perticone, R. Ceravolo, A. Pujia, G. Ventura, S. Iacopino, A. Scozzafava, A. Ferraro, M. Chello, P. Mastroroberto, P. Verdecchia, et al. Prognostic Significance of Endothelial Dysfunction in Hypertensive Patients Circulation, July 10, 2001; 104(2): 191 - 196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Ruschitzka, T. Quaschning, G. Noll, A. deGottardi, M. F. Rossier, F. Enseleit, D. Hurlimann, T. F. Luscher, and S. G. Shaw Endothelin 1 Type A Receptor Antagonism Prevents Vascular Dysfunction and Hypertension Induced by 11{beta}-Hydroxysteroid Dehydrogenase Inhibition : Role of Nitric Oxide Circulation, June 26, 2001; 103(25): 3129 - 3135. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Goh, A. C. Shore, M. Quinn, and J. E. Tooke Impaired Microvascular Vasodilatory Function in 3-Month-Old Infants of Low Birth Weight Diabetes Care, June 1, 2001; 24(6): 1102 - 1107. [Abstract] [Full Text]
|
|
|
|
|
|
S. Taddei, A. Virdis, L. Ghiadoni, A. Magagna, S. Favilla, A. Pompella, and A. Salvetti Restoration of Nitric Oxide Availability After Calcium Antagonist Treatment in Essential Hypertension Hypertension, March 1, 2001; 37(3): 943 - 948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. P. Rossi, S. Taddei, A. Virdis, L. Ghiadoni, G. Albertin, S. Favilla, I. Sudano, A. C. Pessina, and A. Salvetti Exclusion of the ACE D/I Gene Polymorphism as a Determinant of Endothelial Dysfunction Hypertension, February 1, 2001; 37(2): 293 - 300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Bragulat, Alejandro de la Sierra, M. T. Antonio, and A. Coca Endothelial Dysfunction in Salt-Sensitive Essential Hypertension Hypertension, February 1, 2001; 37(2): 444 - 448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Hamilton, M. J. Brosnan, M. McIntyre, D. Graham, and A. F. Dominiczak Superoxide Excess in Hypertension and Aging : A Common Cause of Endothelial Dysfunction Hypertension, February 1, 2001; 37(2): 529 - 534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Quaschning, F. Ruschitzka, S. Shaw, and T. F. Luscher Aldosterone Receptor Antagonism Normalizes Vascular Function in Liquorice-Induced Hypertension Hypertension, February 1, 2001; 37(2): 801 - 805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. A. Paniagua, M. B. Bryant, and J. A. Panza Transient Hypertension Directly Impairs Endothelium-Dependent Vasodilation of the Human Microvasculature Hypertension, December 1, 2000; 36(6): 941 - 944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-T. DIJKHORST-OEI, P. BOER, T. J. RABELINK, and H. A. KOOMANS Nitric Oxide Synthesis Inhibition Does Not Impair Water Immersion-Induced Renal Vasodilation in Humans J. Am. Soc. Nephrol., July 1, 2000; 11(7): 1293 - 1302. [Abstract] [Full Text]
|
|
|
|
|
|
A. Virdis, L. Ghiadoni, S. Pinto, M. Lombardo, F. Petraglia, A. Gennazzani, S. Buralli, S. Taddei, and A. Salvetti Mechanisms Responsible for Endothelial Dysfunction Associated With Acute Estrogen Deprivation in Normotensive Women Circulation, May 16, 2000; 101(19): 2258 - 2263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Sherman, J. F. Keaney Jr, E. S. Biegelsen, S. J. Duffy, J. D. Coffman, and J. A. Vita Pharmacological Concentrations of Ascorbic Acid Are Required for the Beneficial Effect on Endothelial Vasomotor Function in Hypertension Hypertension, April 1, 2000; 35(4): 936 - 941. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Didion, C. D. Sigmund, F. M. Faraci, and Z. S. Katusic Impaired Endothelial Function in Transgenic Mice Expressing Both Human Renin and Human Angiotensinogen • Editorial Comment Stroke, March 1, 2000; 31(3): 760 - 765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Brown, K.-S. Kim, Y.-Q. Chen, L. S. Blevins, J. H. Nadeau, S. G. Meranze, and D. E. Vaughan Synergistic Effect of Adrenal Steroids and Angiotensin II on Plasminogen Activator Inhibitor-1 Production J. Clin. Endocrinol. Metab., January 1, 2000; 85(1): 336 - 344. [Abstract] [Full Text]
|
|
|
|
|
|
L. Ghiadoni, A. Virdis, A. Magagna, S. Taddei, and A. Salvetti Effect of the Angiotensin II Type 1 Receptor Blocker Candesartan on Endothelial Function in Patients With Essential Hypertension Hypertension, January 1, 2000; 35(1): 501 - 506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Taddei, L. Ghiadoni, A. Virdis, S. Buralli, and A. Salvetti Vasodilation to Bradykinin Is Mediated by an Ouabain-Sensitive Pathway as a Compensatory Mechanism for Impaired Nitric Oxide Availability in Essential Hypertensive Patients Circulation, September 28, 1999; 100(13): 1400 - 1405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kerr, M. J. Brosnan, M. McIntyre, J. L. Reid, A. F. Dominiczak, and C. A. Hamilton Superoxide Anion Production Is Increased in a Model of Genetic Hypertension : Role of the Endothelium Hypertension, June 1, 1999; 33(6): 1353 - 1358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Muiesan, M. Salvetti, C. Monteduro, D. Rizzoni, R. Zulli, C. Corbellini, C. Brun, and E. Agabiti-Rosei Effect of Treatment on Flow-Dependent Vasodilation of the Brachial Artery in Essential Hypertension Hypertension, January 1, 1999; 33(1): 575 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Perticone, R. Ceravolo, R. Maio, G. Ventura, S. Iacopino, G. Cuda, P. Mastroroberto, M. Chello, and P. L. Mattioli Calcium antagonist isradipine improves abnormal endothelium-dependent vasodilation in never treated hypertensive patients Cardiovasc Res, January 1, 1999; 41(1): 299 - 306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kennon, A. Suliman, P. K. MacCallum, K. Ranjadayalan, P. Wilkinson, and A. D. Timmis Clinical characteristics determining the mode of presentation in patients with acute coronary syndromes J. Am. Coll. Cardiol., December 1, 1998; 32(7): 2018 - 2022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cardillo, C. M. Kilcoyne, R. O. Cannon III, and J. A. Panza Impairment of the nitric oxide-mediated vasodilator response to mental stress in hypertensive but not in hypercholesterolemic patients J. Am. Coll. Cardiol., November 1, 1998; 32(5): 1207 - 1213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Radaelli, L. Mircoli, I. Mori, G. Mancia, and A. U. Ferrari Nitric Oxide–Dependent Vasodilation in Young Spontaneously Hypertensive Rats Hypertension, October 1, 1998; 32(4): 735 - 739. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Frielingsdorf, P. Kaufmann, T. Suter, R. Hug, and O. M. Hess Percutaneous Transluminal Coronary Angioplasty Reverses Vasoconstriction of Stenotic Coronary Arteries in Hypertensive Patients Circulation, September 22, 1998; 98(12): 1192 - 1197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ghiadoni, S. Taddei, A. Virdis, I. Sudano, V. Di Legge, M. Meola, L. Di Venanzio, and A. Salvetti Endothelial Function and Common Carotid Artery Wall Thickening in Patients With Essential Hypertension Hypertension, July 1, 1998; 32(1): 25 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Taddei, A. Virdis, L. Ghiadoni, A. Magagna, and A. Salvetti Vitamin C Improves Endothelium-Dependent Vasodilation by Restoring Nitric Oxide Activity in Essential Hypertension Circulation, June 9, 1998; 97(22): 2222 - 2229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cardillo, C. M. Kilcoyne, R. O. Cannon III, and J. A. Panza Racial Differences in Nitric Oxide–Mediated Vasodilator Response to Mental Stress in the Forearm Circulation Hypertension, June 1, 1998; 31(6): 1235 - 1239. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Wight, C. F. Kung, P. Moreau, H. Takase, and T. F. Luscher Chronic Blockade of Nitric Oxide-Synthase and Endothelin Receptors During Pregnancy in the Rat: Effect on Pregnancy Outcome Reproductive Sciences, May 1, 1998; 5(3): 132 - 139. [Abstract] [PDF]
|
|
|
|
 |
|
 C. Cardillo and J. A Panza Impaired endothelial regulation of vascular tone in patients with systemic arterial hypertension Vascular Medicine, May 1, 1998; 3(2): 138 - 144. [Abstract] [PDF]
|
|
|
|
|
|
J. P Noon, B. R Walker, M. F Hand, and D. J Webb Impairment of forearm vasodilatation to acetylcholine in hypercholesterolemia is reversed by aspirin Cardiovasc Res, May 1, 1998; 38(2): 480 - 484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Perticone, R. Ceravolo, R. Maio, G. Ventura, A. Zingone, N. Perrotti, and P. L. Mattioli Angiotensin-Converting Enzyme Gene Polymorphism Is Associated With Endothelium-Dependent Vasodilation in Never Treated Hypertensive Patients Hypertension, April 1, 1998; 31(4): 900 - 905. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cardillo, C. M. Kilcoyne, A. A. Quyyumi, R. O. Cannon III, and J. A. Panza Selective Defect in Nitric Oxide Synthesis May Explain the Impaired Endothelium-Dependent Vasodilation in Patients With Essential Hypertension Circulation, March 10, 1998; 97(9): 851 - 856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Husain, N. P. Andrews, D. Mulcahy, J. A. Panza, and A. A. Quyyumi Aspirin Improves Endothelial Dysfunction in Atherosclerosis Circulation, March 3, 1998; 97(8): 716 - 720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hayakawa and L. Raij Nitric Oxide Synthase Activity and Renal Injury in Genetic Hypertension Hypertension, January 1, 1998; 31(1): 266 - 270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Gauthier-Rein and N. J. Rusch Distinct Endothelial Impairment in Coronary Microvessels from Hypertensive Dahl Rats Hypertension, January 1, 1998; 31(1): 328 - 334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Rizzoni, E. Porteri, M. Castellano, G. Bettoni, M. L. Muiesan, G. Tiberio, S. M. Giulini, G. Rossi, G. Bernini, and E. Agabiti-Rosei Endothelial Dysfunction in Hypertension Is Independent From the Etiology and From Vascular Structure Hypertension, January 1, 1998; 31(1): 335 - 341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Joyner and N. M. Dietz Nitric oxide and vasodilation in human limbs J Appl Physiol, December 1, 1997; 83(6): 1785 - 1796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Taddei, A. Virdis, L. Ghiadoni, S. Uleri, A. Magagna, and A. Salvetti Lacidipine Restores Endothelium-Dependent Vasodilation in Essential Hypertensive Patients Hypertension, December 1, 1997; 30(6): 1606 - 1612. [Abstract] [Full Text]
|
|
|
|
|
|
H. O. Steinberg, B. Bayazeed, G. Hook, A. Johnson, J. Cronin, and A. D. Baron Endothelial Dysfunction Is Associated With Cholesterol Levels in the High Normal Range in Humans Circulation, November 18, 1997; 96(10): 3287 - 3293. [Abstract] [Full Text]
|
|
|
|
|
|
C. Cardillo, C. M. Kilcoyne, R. O. Cannon III, A. A. Quyyumi, and J. A. Panza Xanthine Oxidase Inhibition With Oxypurinol Improves Endothelial Vasodilator Function in Hypercholesterolemic but Not in Hypertensive Patients Hypertension, July 1, 1997; 30(1): 57 - 63. [Abstract] [Full Text]
|
|
|
|
|
|
J. Hoyer, R. Kohler, and A. Distler Mechanosensitive Cation Channels in Aortic Endothelium of Normotensive and Hypertensive Rats Hypertension, July 1, 1997; 30(1): 112 - 119. [Abstract] [Full Text]
|
|
|
|
|
|
S. Taddei, A. Virdis, P. Mattei, L. Ghiadoni, C. B. Fasolo, I. Sudano, and A. Salvetti Hypertension Causes Premature Aging of Endothelial Function in Humans Hypertension, March 1, 1997; 29(3): 736 - 743. [Abstract] [Full Text]
|
|
|
|
|
|
H. Hayakawa and L. Raij The Link Among Nitric Oxide Synthase Activity, Endothelial Function, and Aortic and Ventricular Hypertrophy in Hypertension Hypertension, January 1, 1997; 29(1): 235 - 241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pinto, A. Virdis, L. Ghiadoni, G. Bernini, M. Lombardo, F. Petraglia, A. R. Genazzani, S. Taddei, and A. Salvetti Endogenous Estrogen and Acetylcholine-Induced Vasodilation in Normotensive Women Hypertension, January 1, 1997; 29(1): 268 - 273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Taddei, A. Virdis, L. Ghiadoni, A. Magagna, and A. Salvetti Cyclooxygenase Inhibition Restores Nitric Oxide Activity in Essential Hypertension Hypertension, January 1, 1997; 29(1): 274 - 279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Antony, G. Lerebours, and A. Nitenberg Angiotensin-Converting Enzyme Inhibition Restores Flow-Dependent and Cold Pressor Test–Induced Dilations in Coronary Arteries of Hypertensive Patients Circulation, December 15, 1996; 94(12): 3115 - 3122. [Abstract] [Full Text]
|
|
|
|
|
|
D. Rizzoni, E. Porteri, M. Castellano, G. Bettoni, M. L. Muiesan, P. Muiesan, S. M. Giulini, and E. Agabiti-Rosei Vascular Hypertrophy and Remodeling in Secondary Hypertension Hypertension, November 1, 1996; 28(5): 785 - 790. [Abstract] [Full Text]
|
|
|
|
|
|
S. Taddei, A. Virdis, L. Ghiadoni, P. Mattei, I. Sudano, G. Bernini, S. Pinto, and A. Salvetti Menopause Is Associated With Endothelial Dysfunction in Women Hypertension, October 1, 1996; 28(4): 576 - 582. [Abstract] [Full Text]
|
|
|
|
|
|
S. Taddei, A. Virdis, P. Mattei, L. Ghiadoni, I. Sudano, and A. Salvetti Defective L-Arginine–Nitric Oxide Pathway in Offspring of Essential Hypertensive Patients Circulation, September 15, 1996; 94(6): 1298 - 1303. [Abstract] [Full Text]
|
|