Hypertension, Vol 21, 944-948, Copyright © 1993 by American Heart Association
B Jover, A Herizi, F Ventre, M Dupont and A Mimran
The influence of dietary sodium restriction and angiotensin II blockade on
hypertension induced by a 25-day period of administration of the inhibitor
of nitric oxide synthesis NG-nitro-L-arginine-methyl ester (10 mg/kg twice
daily by gavage) was assessed in Wistar rats fed a normal or low sodium
diet. In addition, the angiotensin II receptor blocker losartan (30 mg/kg
once daily by gavage) was administered before and during
NG-nitro-L-arginine-methyl ester in rats fed the normal sodium diet. At the
end of the studies, conscious systolic arterial pressure increased
similarly in NG-nitro-L-arginine-methyl ester-treated groups maintained on
normal or low sodium intake. Moreover, a 25% reduction in cardiac output
due to a decrease in stroke volume was observed in both groups. A slight
but significant cardiac hypertrophic response was observed in hypertensive
rats irrespective of sodium intake. At the completion of studies, plasma
renin activity was similar to corresponding controls in the hypertensive
groups on normal or low sodium intake. Losartan totally prevented the
development of hypertension as well as the decrease in stroke volume and
cardiac hypertrophy associated with NG-nitro-L-arginine-methyl ester
treatment in rats on normal sodium intake. In conclusion, hypertension
resulting from long-term blockade of nitric oxide synthesis was not
affected by dietary sodium restriction. A crucial role for the
renin-angiotensin system was demonstrated in this new model of
hypertension.
ARTICLES
Sodium and angiotensin in hypertension induced by long-term nitric oxide blockade
Groupe Rein et Hypertension, Centre Hospitalier Universitaire, Montpellier, France.
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