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Hypertension, Vol 22, 40-48, Copyright © 1993 by American Heart Association

ARTICLES

Cardiovascular responses to long-term blockade of nitric oxide synthesis

RD Manning Jr, L Hu, HL Mizelle, JP Montani and MW Norton
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505.

The goal of this study was to determine if there is a basal release of nitric oxide that affects long-term arterial pressure regulation in dogs. Studies were conducted over a 23-day period in eight conscious dogs with indwelling catheters. Nitric oxide synthesis was blocked by continuous intravenous infusion of nitro-L-arginine-methyl ester at 37.1 nmol/kg per minute for 11 days. Arterial pressure increased to 120 +/- 4% of control on the first day, decreased for a few days, and then increased to a maximum value of 122 +/- 6% of control on day 7. Bradycardia was sustained throughout the entire nitro-arginine period. Blockade of nitric oxide synthesis was evidenced by attenuated pressure and flow responses to systemic acetylcholine infusion. The pressor response to phenylephrine was increased for only 1 day, and the hypotensive effects of nitroprusside were enhanced. Also, the variability of arterial pressure was significantly increased during nitro-arginine. Sodium and water balances were positive the first day of nitro-arginine infusion but were unchanged for the entire nitro- arginine period. In conclusion, the data suggest that blockade of the basal release of nitric oxide in dogs causes an increase in the long- term level of arterial pressure without any sustained sodium or water retention.

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