Hypertension, Vol 22, 67-73, Copyright © 1993 by American Heart Association
K Sakai, T Imaizumi, H Masaki and A Takeshita
Hyperinsulinemia may contribute to the development of hypertension. The aim
of the present study was to determine whether hyperinsulinemia modulates
vascular reactivity to phenylephrine or angiotensin II. In 10 young,
healthy volunteers, the left brachial artery was cannulated for drug
infusion and direct measurements of arterial pressure. We measured forearm
blood flow by a strain-gauge plethysmograph while infusing phenylephrine
(0.2, 0.8, and 2.4 micrograms/min) and angiotensin II (5, 10, and 20
ng/min) locally into the brachial artery before and during simultaneous
intra-arterial infusion of insulin (0.15 mU/kg per minute). Forearm
vascular resistance was calculated from directly measured arterial pressure
and forearm blood flow. Intra-arterial infusion of insulin raised the local
plasma insulin level from 10.3 +/- 1.4 to 133.3 +/- 21.1 microU/mL (P <
.01) and did not change blood glucose level in the venous effluents of the
forearm. Insulin infusion slightly but not significantly increased basal
forearm blood flow (4.6 +/- 1.5 to 5.5 +/- 0.9 mL/min per 100 milliliters,
NS) and decreased forearm vascular resistance (22.1 +/- 2.1 to 20.3 +/- 2.8
U, NS). Phenylephrine and angiotensin II increased forearm vascular
resistance dose dependently before and during simultaneous insulin infusion
(P < .01 for both). Intra-arterial infusion of insulin attenuated
vascular reactivity to phenylephrine (P < .01) and angiotensin II (P
< .01). None of these drugs changed blood pressure or heart rate. Our
results suggest that hyperinsulinemia attenuates vascular reactivity in the
forearm resistance vessels in healthy humans.
ARTICLES
Intra-arterial infusion of insulin attenuates vasoreactivity in human forearm
Cardiology Section, National Fukuoka Hospital, Japan.
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