| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Hypertension, Vol 22, 97-101, Copyright © 1993 by American Heart Association
B Lemmer, A Mattes, M Bohm and D Ganten
Automatic, around-the-clock blood pressure measurements have increased our
understanding of hypertension in humans. Patients with essential
hypertension display patterns similar to those observed in normotensive
subjects, whereas those with secondary hypertension frequently show
abnormal circadian rhythms characterized by a failure to reduce blood
pressure at night. We have modeled this situation in rats. Normotensive
Wistar-Kyoto and Sprague-Dawley rats, spontaneously hypertensive rats, and
rats made hypertensive by transgenic implantation of the mouse salivary
gland renin gene (TGR[mRen-2]27) underwent chronic implantation of a device
that telemetrically monitored their blood pressures, heart rates, and motor
activities. In either normotensive or hypertensive rats, motor activity
peaked during the dark phase, indicating that animals from all strains were
nocturnal. In both normotensive and spontaneously hypertensive rats, the
24-hour blood pressure and heart rate profiles showed peak values during
the rats' active phase at night, ie, between midnight and 3 AM. In the
transgenic rats, on the other hand, blood pressure values were at maximum
during the day around noon, when the rats were in their resting phase. The
heart rate of the transgenic rats nevertheless still peaked around
midnight. These data suggest that normotensive rats and those with primary
and secondary hypertension display circadian rhythms of blood pressure and
heart rate analogous to those observed in normotensive and primary or
secondary hypertensive humans, respectively. The TGR(mRen- 2)27 strain may
be a useful model with which to investigate the mechanisms responsible for
alterations in circadian rhythms of blood pressure and heart rate in forms
of secondary hypertension.
ARTICLES
Circadian blood pressure variation in transgenic hypertensive rats
Center of Pharmacology, JW Goethe-University, Frankfurt, Germany.
This article has been cited by other articles:
 |
|
 |
|
  L. Gao, W. Wang, W. Wang, H. Li, C. Sumners, and I. H. Zucker Effects of Angiotensin Type 2 Receptor Overexpression in the Rostral Ventrolateral Medulla on Blood Pressure and Urine Excretion in Normal Rats Hypertension, February 1, 2008; 51(2): 521 - 527. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. F. Reilly, E. J. Westgate, and G. A. FitzGerald Peripheral Circadian Clocks in the Vasculature Arterioscler Thromb Vasc Biol, August 1, 2007; 27(8): 1694 - 1705. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. A. Cupples and B. Braam Assessment of renal autoregulation Am J Physiol Renal Physiol, April 1, 2007; 292(4): F1105 - F1123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Baudrie, D. Laude, and J.-L. Elghozi Optimal frequency ranges for extracting information on cardiovascular autonomic control from the blood pressure and pulse interval spectrograms in mice Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R904 - R912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Campos, R. Plehm, J. Cipolla-Neto, M. Bader, and O. C. Baltatu Altered circadian rhythm reentrainment to light phase shifts in rats with low levels of brain angiotensinogen Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R1122 - R1127. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Wauschkuhn, K. Witte, S. Gorbey, B. Lemmer, and L. Schilling Circadian periodicity of cerebral blood flow revealed by laser-Doppler flowmetry in awake rats: relation to blood pressure and activity Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1662 - H1668. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Peng, J. T. Clark, J. Prasain, H. Kim, C. R. White, and J. M. Wyss Antihypertensive and cognitive effects of grape polyphenols in estrogen-depleted, female, spontaneously hypertensive rats Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2005; 289(3): R771 - R775. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. W. Kurtz, K. A. Griffin, A. K. Bidani, R. L. Davisson, and J. E. Hall Recommendations for Blood Pressure Measurement in Humans and Experimental Animals: Part 2: Blood Pressure Measurement in Experimental Animals. A Statement for Professionals From the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research Arterioscler Thromb Vasc Biol, March 1, 2005; 25(3): e22 - e33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. W. Kurtz, K. A. Griffin, A. K. Bidani, R. L. Davisson, and J. E. Hall Recommendations for Blood Pressure Measurement in Humans and Experimental Animals: Part 2: Blood Pressure Measurement in Experimental Animals: A Statement for Professionals From the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research Hypertension, February 1, 2005; 45(2): 299 - 310. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kramer and L. B. Kinter Evaluation and applications of radiotelemetry in small laboratory animals Physiol Genomics, May 13, 2003; 13(3): 197 - 205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. G. Braga, M. Da Silva Lemos, J. R. Da Silva, W. R. P. Fontes, and R. Augusto Souza Dos Santos Effects of angiotensins on day-night fluctuations and stress-induced changes in blood pressure Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1663 - R1671. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Bader and D. Ganten It's Renin in the Brain: Transgenic Animals Elucidate the Brain Renin-Angiotensin System Circ. Res., January 11, 2002; 90(1): 8 - 10. [Full Text] [PDF]
|
|
|
|
|
|
O. Baltatu, B. J. Janssen, G. Bricca, R. Plehm, J. Monti, D. Ganten, and M. Bader Alterations in Blood Pressure and Heart Rate Variability in Transgenic Rats With Low Brain Angiotensinogen Hypertension, February 1, 2001; 37(2): 408 - 413. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Witte, K. Hu, J. Swiatek, C. Mussig, G. Ertl, and B. Lemmer Experimental heart failure in rats: effects on cardiovascular circadian rhythms and on myocardial {beta}-adrenergic signaling Cardiovasc Res, August 1, 2000; 47(2): 350 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.-L. Zhang, E. Zannou, and F. Sannajust Effects of photoperiod reduction on rat circadian rhythms of BP, heart rate, and locomotor activity Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2000; 279(1): R169 - R178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Muntzel, I. Hamidou, and S. Barrett Metformin Attenuates Salt-Induced Hypertension in Spontaneously Hypertensive Rats Hypertension, May 1, 1999; 33(5): 1135 - 1140. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Schinke, O. Baltatu, M. Bohm, J. Peters, W. Rascher, G. Bricca, A. Lippoldt, D. Ganten, and M. Bader Blood pressure reduction and diabetes insipidus in transgenic rats deficient in brain angiotensinogen PNAS, March 30, 1999; 96(7): 3975 - 3980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. H. Anderson, A. M. Devlin, D. Graham, J. J. Morton, C. A. Hamilton, J. L. Reid, N. J. Schork, and A. F. Dominiczak Telemetry for Cardiovascular Monitoring in a Pharmacological Study : New Approaches to Data Analysis Hypertension, January 1, 1999; 33(1): 248 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Li, M. Morris, C. M. Ferrario, C. Barrett, D. Ganten, and M. F. Callahan Cardiovascular, endocrine, and body fluid-electrolyte responses to salt loading in mRen-2 transgenic rats Am J Physiol Heart Circ Physiol, October 1, 1998; 275(4): H1130 - H1137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Whitworth, M. M. Veniant, J. D. Firth, A. D. Cumming, and J. J. Mullins Endothelin in the Kidney in Malignant Phase Hypertension Hypertension, December 1, 1995; 26(6): 925 - 931. [Abstract] [Full Text]
|
|
|
|
|
|
A. O. Davidson, N. Schork, B. C. Jaques, A. W. Kelman, R. G. Sutcliffe, J. L. Reid, and A. F. Dominiczak Blood Pressure in Genetically Hypertensive Rats : Influence of the Y Chromosome Hypertension, September 1, 1995; 26(3): 452 - 459. [Abstract] [Full Text]
|
|
|
|
 |
|
 W. S. Warren and V. M. Cassone The Pineal Gland: Photoreception and Coupling of Behavioral, Metabolic, and Cardiovascular Circadian Outputs J Biol Rhythms, March 1, 1995; 10(1): 64 - 79. [Abstract] [PDF]
|
|