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Hypertension, Vol 22, 257-267, Copyright © 1993 by American Heart Association

ARTICLES

De novo hypertension after liver transplantation [clinical conference]

SC Textor
Division of Hypertension, Mayo Clinic, Rochester, Minnesota.

Hypertension develops in most patients after transplantation when immunosuppression is based on cyclosporine and prednisone. The pathogenesis appears to be multifactorial but involves rapidly rising vasoconstrictor tone in renal and systemic vascular beds. Much of this tone reflects abnormal vascular function, characterized by impaired prostacyclin and EDRF effects, in conjunction with increased vasoconstriction due to endothelin and possibly other factors. Effective management of the transplant recipient depends on preventing excessive vasoconstriction, usually with calcium channel blocking agents.

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