Hypertension, Vol 22, 357-364, Copyright © 1993 by American Heart Association
JD Imig, JR Falck, D Gebremedhin, DR Harder and RJ Roman
The present study examined the role of cytochrome P-450 metabolites of
arachidonic acid in elevating renal vascular resistance in young
spontaneously hypertensive rats (SHR). Differences in vascular tone were
assessed in the preglomerular vasculature of 3- to 4-week-old
prehypertensive SHR (n = 11) and normotensive Wistar-Kyoto (WKY, n = 10)
and Wistar-Lewis (n = 10) rats. Pressure-diameter relations to changes in
renal perfusion pressure were compared using the juxtamedullary nephron
microvascular preparation perfused in vitro with a physiological salt
solution. At a pressure of 60 mm Hg, the basal diameters of the
interlobular arteries and proximal and distal afferent arterioles of the
SHR averaged 43 +/- 2, 17 +/- 0.3, and 11 +/- 0.4 microns, respectively.
The diameters of the interlobular arteries and afferent arterioles were 9%
to 14% smaller than those of corresponding vessels in WKY and Wistar-Lewis
rats. Addition of P-450 inhibitors, ketoconazole (100 mumol/L) or
7-ethoxyresorufin (1 mumol/L), to the perfusate dilated the afferent
arteriole of SHR by 7% to 12%, whereas it increased the diameter by only 0%
to 6% in control rats and significantly reduced the differences in the
pressure-diameter relation in the preglomerular vasculature of SHR and
control rats. Inhibitors of P-450 eliminated the contractile response of
afferent arterioles to increases in renal perfusion pressure in all three
groups. Removal of calcium from the perfusate eliminated differences in the
diameters of the preglomerular vasculature in SHR and normotensive
rats.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Elevated renovascular tone in young spontaneously hypertensive rats. Role of cytochrome P-450
Department of Physiology, Medical College of Wisconsin, Milwaukee 53226.
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