Hypertension, Vol 22, 496-501, Copyright © 1993 by American Heart Association
P Eggena, JH Zhu, K Clegg and JD Barrett
The observation that nuclei from hepatic tissue exhibit specific
angiotensin II (Ang II) binding led us to explore whether Ang II modulates
mRNA in general, mRNA specific for renin system components, or both. Nuclei
from hepatic tissue exhibited a single high-affinity (Kd = 0.4 nmol/L) Ang
II-specific binding site, which was associated with increased RNA
transcription. Whereas total RNA extracted from nuclei increased 1.5-fold
in response to Ang II (10(-9) mol/L), specific mRNA for renin and
angiotensinogen increased 7.8- and 2.5- fold, respectively. Ang II binding
and induced transcription showed parallel Ang II dose responses that were
both inhibited by 10(-5) mol/L DuP 753 or saralasin. Maximum Ang II binding
and RNA transcription occurred at the same Ang II concentration (10(-9)
mol/L). Higher doses of Ang II resulted in a progressive decrease in RNA
transcription. Together, these results demonstrate that hepatic nuclei have
functional Ang II-specific receptors. It is concluded that Ang II may
elicit responses at nuclear receptors, which heretofore were associated
only with Ang II receptors located on plasma membranes. However, the
individual contribution of plasma and nuclear membrane Ang II receptors to
the overall cellular Ang II transcriptional response and their possible
interactions remain to be determined.
ARTICLES
Nuclear angiotensin receptors induce transcription of renin and angiotensinogen mRNA
Renin Biochemistry/Vascular Pharmacology Laboratories, Department of Veterans Affairs Medical Center, Sepulveda, CA 91343.
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|
|
|
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|
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