Hypertension, Vol 22, 535-541, Copyright © 1993 by American Heart Association
DS Majid, A Williams, PJ Kadowitz and LG Navar
Inhibition of nitric oxide synthesis by intra-arterial administration of
nitro-L-arginine (NLA) leads to attenuation of the slope of the relation
between renal arterial pressure (RAP) and sodium excretion without an
alteration in renal autoregulatory efficiency. In the present study, we
examined whether only the presence of nitric oxide or, alternatively,
changes in nitric oxide production during changes in RAP are required for
pressure natriuresis to occur. Anesthetized sodium- replete dogs (n = 8)
were treated with NLA (50 micrograms.kg-1 x min-1) to inhibit endogenous
nitric oxide formation, and S-nitroso-n- acetylpenicillamine (SNAP) was
infused intra-arterially at a constant rate (2 micrograms.kg-1 x min-1) to
replenish intrarenal nitric oxide levels. Renal responses to reductions in
RAP within the autoregulatory range were assessed before and during NLA
infusion followed by SNAP+NLA infusion. As reported previously, NLA
infusion alone increased renal vascular resistance and decreased renal
blood flow, urine flow, sodium excretion, and fractional excretion of
sodium, with no change in glomerular filtration rate. Autoregulatory
efficiency remained intact, whereas the pressure-induced natriuretic
responses were attenuated. During SNAP+NLA infusion, renal blood flow
increased from 2.8 +/- 0.3 to 3.5 +/- 0.3 mL.min-1 x g-1 (P < .001),
without significant changes in glomerular filtration rate (0.75 +/- 0.07 to
0.81 +/- 0.05 mL.min-1 x g-1); the autoregulatory efficiency of renal blood
flow and glomerular filtration rate remained intact. SNAP increased urine
flow (4.8 +/- 1.8 to 10.0 +/- 2.5 microL.min-1 x g-1), sodium excretion
(0.63 +/- 0.26 to 1.70 +/- 0.37 mumol.min-1 x g-1), and fractional
excretion of sodium (0.55 +/- 0.20% to 1.38 +/- 0.27%).(ABSTRACT TRUNCATED
AT 250 WORDS)
ARTICLES
Renal responses to intra-arterial administration of nitric oxide donor in dogs
Department of Physiology, Tulane University School of Medicine, New Orleans, LA 70112.
This article has been cited by other articles:
 |
|
 |
|
  Y. Shi, C. Lau, and W. A. Cupples Interactive modulation of renal myogenic autoregulation by nitric oxide and endothelin acting through ET-B receptors Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R354 - R361. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Herrera, P. A. Ortiz, and J. L. Garvin Regulation of thick ascending limb transport: role of nitric oxide Am J Physiol Renal Physiol, June 1, 2006; 290(6): F1279 - F1284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Varela, M. Herrera, and J. L. Garvin Inhibition of Na-K-ATPase in thick ascending limbs by NO depends on O2- and is diminished by a high-salt diet Am J Physiol Renal Physiol, August 1, 2004; 287(2): F224 - F230. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Varela and J. L. Garvin Acute and Chronic Regulation of Thick Ascending Limb Endothelial Nitric Oxide Synthase by Statins J. Am. Soc. Nephrol., February 1, 2004; 15(2): 269 - 275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Ortiz and J. L. Garvin Role of nitric oxide in the regulation of nephron transport Am J Physiol Renal Physiol, May 1, 2002; 282(5): F777 - F784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S.A. Majid and A. Nishiyama Nitric Oxide Blockade Enhances Renal Responses to Superoxide Dismutase Inhibition in Dogs Hypertension, February 1, 2002; 39(2): 293 - 297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Ortiz and J. L. Garvin Interaction of O2- and NO in the Thick Ascending Limb Hypertension, February 1, 2002; 39(2): 591 - 596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Lopez, C. Moreno, M. G. Salom, R. J. Roman, and F. J. Fenoy Role of guanylyl cyclase and cytochrome P-450 on renal response to nitric oxide Am J Physiol Renal Physiol, September 1, 2001; 281(3): F420 - F427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kakoki, A.-P. Zou, and D. L. Mattson The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2001; 281(1): R91 - R97. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. A. Majid, K. E. Said, S. A. Omoro, and L. G. Navar Nitric Oxide Dependency of Arterial Pressure-Induced Changes in Renal Interstitial Hydrostatic Pressure in Dogs Circ. Res., February 16, 2001; 88(3): 347 - 351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Ortiz and J. L. Garvin NO Inhibits NaCl Absorption by Rat Thick Ascending Limb Through Activation of cGMP-Stimulated Phosphodiesterase Hypertension, February 1, 2001; 37(2): 467 - 471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. A. Majid, K. E. Said, and S. A. Omoro Responses to Acute Changes in Arterial Pressure on Renal Medullary Nitric Oxide Activity in Dogs Hypertension, October 1, 1999; 34(4): 832 - 836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Garvin and N. J. Hong Nitric oxide inhibits sodium/hydrogen exchange activity in the thick ascending limb Am J Physiol Renal Physiol, September 1, 1999; 277(3): F377 - F382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Braam Renal endothelial and macula densa NOS: integrated response to changes in extracellular fluid volume Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1999; 276(6): R1551 - R1561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Kone and S. Higham Nitric oxide inhibits transcription of the Na+-K+-ATPase alpha 1-subunit gene in an MTAL cell line Am J Physiol Renal Physiol, April 1, 1999; 276(4): F614 - F621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. A. MAJID, E. W. INSCHO, and L. G. NAVAR P2 Purinoceptor Saturation by Adenosine Triphosphate Impairs Renal Autoregulation in Dogs J. Am. Soc. Nephrol., March 1, 1999; 10(3): 492 - 498. [Abstract] [Full Text]
|
|
|
|
|
|
A. Just, H. Ehmke, U. Wittmann, and H. R. Kirchheim Tonic and phasic influences of nitric oxide on renal blood flow autoregulation in conscious dogs Am J Physiol Renal Physiol, March 1, 1999; 276(3): F442 - F449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Plato, B. A. Stoos, D. Wang, and J. L. Garvin Endogenous nitric oxide inhibits chloride transport in the thick ascending limb Am J Physiol Renal Physiol, January 1, 1999; 276(1): F159 - F163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. A. Majid, S. A. Omoro, S. Y. Chin, and L. G. Navar Intrarenal Nitric Oxide Activity and Pressure Natriuresis in Anesthetized Dogs Hypertension, August 1, 1998; 32(2): 266 - 272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Godfrey and D. S. A. Majid Renal handling of circulating nitrates in anesthetized dogs Am J Physiol Renal Physiol, July 1, 1998; 275(1): F68 - F73. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Laycock, T. Vogel, P. R. Forfia, J. Tuzman, X. Xu, M. Ochoa, C. I. Thompson, A. Nasjletti, and T. H. Hintze Role of Nitric Oxide in the Control of Renal Oxygen Consumption and the Regulation of Chemical Work in the Kidney Circ. Res., June 29, 1998; 82(12): 1263 - 1271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-Z. Ying and P. W. Sanders Dietary salt modulates renal production of transforming growth factor-beta in rats Am J Physiol Renal Physiol, April 1, 1998; 274(4): F635 - F641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Madrid, M. Garcia-Salom, J. Tornel, M. De Gasparo, and F. J. Fenoy Effect of interactions between nitric oxide and angiotensin II on pressure diuresis and natriuresis Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1997; 273(5): R1676 - R1682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Madrid, M. Garcia-Salom, J. Tornel, M. de Gasparo, and F. J. Fenoy Interactions Between Nitric Oxide and Angiotensin II on Renal Cortical and Papillary Blood Flow Hypertension, November 1, 1997; 30(5): 1175 - 1182. [Abstract] [Full Text]
|
|
|
|
|
|
D. S. A. Majid, M. Godfrey, and L. G. Navar Pressure Natriuresis and Renal Medullary Blood Flow in Dogs Hypertension, April 1, 1997; 29(4): 1051 - 1057. [Abstract] [Full Text]
|
|
|
|
|
|
D. S.A. Majid, M. Godfrey, and S. A. Omoro Pressure Natriuresis and Autoregulation of Inner Medullary Blood Flow in Canine Kidney Hypertension, January 1, 1997; 29(1): 210 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Deng, W. J. Welch, and C. S. Wilcox Role of Nitric Oxide in Short-term and Prolonged Effects of Angiotensin II on Renal Hemodynamics Hypertension, May 1, 1996; 27(5): 1173 - 1179. [Abstract] [Full Text]
|
|
|
|
|
|
N. H. Garcia, B. A. Stoos, O. A. Carretero, and J. L. Garvin Mechanism of the Nitric Oxide-Induced Blockade of Collecting Duct Water Permeability Hypertension, March 1, 1996; 27(3): 679 - 683. [Abstract] [Full Text]
|
|
|
|
|
|
K. Hayashi, H. Suzuki, and T. Saruta Nitric Oxide Modulates but Does Not Impair Myogenic Vasoconstriction of the Afferent Arteriole in Spontaneously Hypertensive Rats : Studies in the Isolated Perfused Hydronephrotic Kidney Hypertension, June 1, 1995; 25(6): 1212 - 1219. [Abstract] [Full Text]
|
|
|
|
|
|
D. S. A. Majid, M. Godfrey, M. B. Grisham, and L. G. Navar Relation Between Pressure Natriuresis and Urinary Excretion of Nitrate/Nitrite in Anesthetized Dogs Hypertension, April 1, 1995; 25(4): 860 - 865. [Abstract] [Full Text]
|
|
|
|
|
|
F. J. Fenoy, P. Ferrer, L. Carbonell, and M. Garcia-Salom Role of Nitric Oxide on Papillary Blood Flow and Pressure Natriuresis Hypertension, March 1, 1995; 25(3): 408 - 414. [Abstract] [Full Text]
|
|