Hypertension, Vol 22, 801-805, Copyright © 1993 by American Heart Association
DA Calhoun, ML Mutinga, AS Collins, JM Wyss and S Oparil
The purpose of this study was to compare sympathetic nerve activity
responses to the cold pressor test in black and white normotensive
subjects. We recorded muscle sympathetic nerve activity (microneurography
of the peroneal nerve), arterial blood pressure, and heart rate in 9
normotensive American blacks (24 +/- 2 years, mean +/- SEM) and 10
normotensive American whites (28 +/- 2 years) at rest and during hand
immersion in ice water (cold pressor test). Body weight was not different
in the two groups (72.4 +/- 3.7 versus 74.1 +/- 3.8 kg, black versus white
subjects). During supine rest, mean arterial pressure (92 +/- 2 versus 93
+/- 3 mm Hg, black versus white), heart rate (66 +/- 4 versus 62 +/- 3
beats per minute, black versus white), and muscle sympathetic nerve burst
frequency (12 +/- 2 versus 17 +/- 3 bursts per minute, black versus white)
were not different in the two groups. During the cold pressor test, mean
arterial pressure, heart rate, and muscle sympathetic nerve activity
increased from supine rest in both groups. The magnitudes of increases in
mean arterial pressure and total minute muscle sympathetic nerve activity
were significantly greater in blacks than whites (33.5 +/- 3 versus 22.4
+/- 3 mm Hg and 416 +/- 24% versus 243 +/- 31% of control, respectively,
black versus white, P < .05). The increases in heart rate were most
significantly different for the two groups. These data suggest that the
enhanced pressor response to cold stress observed in normotensive blacks is
attributable to greater increases in peripheral sympathetic nerve
activity.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Normotensive blacks have heightened sympathetic response to cold pressor test
Department of Medicine, University of Alabama at Birmingham 35294.
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