Hypertension, Vol 22, 863-869, Copyright © 1993 by American Heart Association
A Patel, S Layne, D Watts and KA Kirchner
A blunted pressure-natriuretic response characterizes hypertension in the
Dahl salt-sensitive rat. Long-term L-arginine administration prevents
hypertension in these animals. To determine if long-term L- arginine
corrects the pressure-natriuretic response, we gave salt- sensitive rats on
an 8% sodium diet L-arginine or vehicle daily for 3 weeks. Identically
treated salt-resistant rats served as controls. After 3 weeks, acute
pressure-natriuresis curves were determined. To control for
hypertension-induced renal damage, we also examined pressure natriuresis in
salt-sensitive rats after short-term L- arginine. Baseline mean arterial
pressure was 158 +/- 3 mm Hg in vehicle-treated salt-sensitive rats and 127
+/- 3 mm Hg in chronically L-arginine-treated salt-sensitive rats. During
alterations in perfusion pressure, renal blood flow was autoregulated in
all groups. Glomerular filtration rate was autoregulated in salt-resistant
rats and L-arginine- treated salt-sensitive rats but fell with decreasing
pressure in vehicle-treated salt-sensitive rats. Sodium excretion was
greater (P < .05) in L-arginine-treated than in vehicle-treated
salt-sensitive rats and did not differ from salt-resistant rats at 100,
125, and 158 mm Hg. The slope of the pressure-natriuresis relation was
greater (P < .05) in chronically L-arginine-treated than in
vehicle-treated salt-sensitive rats. L-Arginine had no effect on
natriuresis in salt-resistant rats. Thus, long-term L-arginine
administration normalizes pressure- natriuretic responses in salt-sensitive
rats. The effect is not due to the prevention of renal damage and is
specific to the salt-sensitive strain.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
L-arginine administration normalizes pressure natriuresis in hypertensive Dahl rats
Department of Medicine, University of Mississippi Medical Center, Jackson 39216-4505.
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