Hypertension, Vol 22, 876-883, Copyright © 1993 by American Heart Association
SJ Marchais, AP Guerin, BM Pannier, BI Levy, ME Safar and GM London
Arterial wave reflections (AWRs), an important determinant of cardiac
afterload, are increased in hemodialysis patients. However, an association
between AWRs and left ventricular hypertrophy has not been established in
these subjects. We therefore sought an association between these two
parameters in a cross-sectional study of two outpatient hemodialysis
populations. AWRs were quantified (augmentation index, percent) as the
ratio of the height of the late systolic peak to the total height of the
carotid pulse wave recorded with a micromanometer-tipped probe. AWRs were
determined in 44 hemodialysis patients, 22 with pronounced AWRs (group A:
augmentation index > 12%), and 22 with small or moderate AWRs (group B:
augmentation index < 12%). The groups were matched for age, sex, blood
pressure, and hemodialysis duration. Left ventricular size was determined
by echocardiography. Despite lower body size (P < .005) and similar
blood pressure, cardiac output, peripheral resistance, and aortic pulse
wave velocity, group A patients had greater left ventricular mass (P <
.01). For the population as a whole, left ventricular mass and AWRs were
positively correlated (P < .0001) independent of age, blood pressure,
hemodialysis duration, or body size. Lesser body height was the principal
factor associated with increased AWRs in group A (P < .001). We conclude
that in hemodialysis patients AWRs are associated with the development of
left ventricular hypertrophy and that small body height is a risk factor
for long-term cardiovascular complications.
ARTICLES
Wave reflections and cardiac hypertrophy in chronic uremia. Influence of body size
Centre Hospitalier F.H. Manhes, Fleury-Merogis, France.
This article has been cited by other articles:
 |
|
 |
|
  A. LeBeouf, F. Mac-Way, M. S. Utescu, N. Chbinou, P. Douville, S. Desmeules, and M. Agharazii Effects of acute variation of dialysate calcium concentrations on arterial stiffness and aortic pressure waveform Nephrol. Dial. Transplant., December 1, 2009; 24(12): 3788 - 3794. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Sharman, J. E. Davies, C. Jenkins, and T. H. Marwick Augmentation Index, Left Ventricular Contractility, and Wave Reflection Hypertension, November 1, 2009; 54(5): 1099 - 1105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Sharman, J. Brown, D. J. Holland, G. Macdonald, K. Kostner, and T. H. Marwick Influence of Altered Blood Rheology on Ventricular-Vascular Response to Exercise Hypertension, November 1, 2009; 54(5): 1092 - 1098. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hornum, P. Clausen, J. Kjaergaard, J. M. Hansen, E. R. Mathiesen, and B. Feldt-Rasmussen Pre-diabetes and arterial stiffness in uraemic patients Nephrol. Dial. Transplant., October 21, 2009; (2009) gfp558v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Sharman, C. M. McEniery, R. Campbell, P. Pusalkar, I. B. Wilkinson, J. S. Coombes, and J. R. Cockcroft Nitric Oxide Does Not Significantly Contribute to Changes in Pulse Pressure Amplification During Light Aerobic Exercise Hypertension, April 1, 2008; 51(4): 856 - 861. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Shimizu and K. Kario Review: Role of the augmentation index in hypertension Therapeutic Advances in Cardiovascular Disease, February 1, 2008; 2(1): 25 - 35. [Abstract] [PDF]
|
|
|
|
 |
|
 R. N. A. Black, M. Spence, R. O. McMahon, G. J. Cuskelly, C. N. Ennis, D. R. McCance, I. S. Young, P. M. Bell, and S. J. Hunter Effect of Eucaloric High- and Low-Sucrose Diets With Identical Macronutrient Profile on Insulin Resistance and Vascular Risk: A Randomized Controlled Trial Diabetes, December 1, 2006; 55(12): 3566 - 3572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Sharman, R. Lim, A. M. Qasem, J. S. Coombes, M. I. Burgess, J. Franco, P. Garrahy, I. B. Wilkinson, and T. H. Marwick Validation of a Generalized Transfer Function to Noninvasively Derive Central Blood Pressure During Exercise Hypertension, June 1, 2006; 47(6): 1203 - 1208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Sharman, Z. Y. Fang, B. Haluska, M. Stowasser, J. B. Prins, and T. H. Marwick Left Ventricular Mass in Patients With Type 2 Diabetes Is Independently Associated With Central but not Peripheral Pulse Pressure Diabetes Care, April 1, 2005; 28(4): 937 - 939. [Full Text] [PDF]
|
|
|
|
 |
|
 J.E. Sharman, J.R. Cockcroft, and J.S. Coombes Cardiovascular implications of exposure to traffic air pollution during exercise QJM, October 1, 2004; 97(10): 637 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Mullan, C. N. Ennis, H. J. P. Fee, I. S. Young, and D. R. McCance Protective effects of ascorbic acid on arterial hemodynamics during acute hyperglycemia Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1262 - H1268. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. de Simone Left Ventricular Geometry and Hypotension in End-Stage Renal Disease: A Mechanical Perspective J. Am. Soc. Nephrol., October 1, 2003; 14(10): 2421 - 2427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Mullan, I. S. Young, H. Fee, and D. R. McCance Ascorbic Acid Reduces Blood Pressure and Arterial Stiffness in Type 2 Diabetes Hypertension, December 1, 2002; 40(6): 804 - 809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Hope, D. B. Tay, I. T. Meredith, and J. D. Cameron Comparison of generalized and gender-specific transfer functions for the derivation of aortic waveforms Am J Physiol Heart Circ Physiol, September 1, 2002; 283(3): H1150 - H1156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zeier and E. Ritz Preparation of the dialysis patient for transplantation Nephrol. Dial. Transplant., April 1, 2002; 17(4): 552 - 556. [Full Text] [PDF]
|
|
|
|
 |
|
 I. B. Wilkinson, K. Prasad, I. R. Hall, A. Thomas, H. MacCallum, D. J. Webb, M. P. Frenneaux, and J. R. Cockcroft Increased central pulse pressure and augmentation index in subjects with hypercholesterolemia J. Am. Coll. Cardiol., March 20, 2002; 39(6): 1005 - 1011. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. B. Wilkinson, S. S. Franklin, I. R. Hall, S. Tyrrell, and J. R. Cockcroft Pressure Amplification Explains Why Pulse Pressure Is Unrelated to Risk in Young Subjects Hypertension, December 1, 2001; 38(6): 1461 - 1466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Smith, S. Bennett, L. M. Evans, H. G. Kynaston, M. Parmar, M. D. Mason, J. R. Cockcroft, M. F. Scanlon, and J. S. Davies The Effects of Induced Hypogonadism on Arterial Stiffness, Body Composition, and Metabolic Parameters in Males with Prostate Cancer J. Clin. Endocrinol. Metab., September 1, 2001; 86(9): 4261 - 4267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Kelly, S. C. Millasseau, J. M. Ritter, and P. J. Chowienczyk Vasoactive Drugs Influence Aortic Augmentation Index Independently of Pulse-Wave Velocity in Healthy Men Hypertension, June 1, 2001; 37(6): 1429 - 1433. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. W. Nichols and D. G. Edwards Arterial Elastance and Wave Reflection Augmentation of Systolic Blood Pressure: Deleterious Effects and Implications for Therapy Journal of Cardiovascular Pharmacology and Therapeutics, March 1, 2001; 6(1): 5 - 21. [Abstract] [PDF]
|
|
|
|
 |
|
 I. B Wilkinson, H. MacCallum, P. C Hupperetz, C. J van Thoor, J. R Cockcroft, and D. J Webb Changes in the derived central pressure waveform and pulse pressure in response to angiotensin II and noradrenaline in man J. Physiol., February 1, 2001; 530(3): 541 - 550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Guerin, G. M. London, S. J. Marchais, and F. Metivier Arterial stiffening and vascular calcifications in end-stage renal disease Nephrol. Dial. Transplant., July 1, 2000; 15(7): 1014 - 1021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I.B. Wilkinson, H. MacCallum, D.F. Rooijmans, G.D. Murray, J.R. Cockcroft, J.A. McKnight, and D.J. Webb Increased augmentation index and systolic stress in type 1 diabetes mellitus QJM, July 1, 2000; 93(7): 441 - 448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. B Wilkinson, H. MacCallum, L. Flint, J. R Cockcroft, D. E Newby, and D. J Webb The influence of heart rate on augmentation index and central arterial pressure in humans J. Physiol., May 15, 2000; 525(1): 263 - 270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Snieder, C. S. Hayward, U. Perks, R. P. Kelly, P. J. Kelly, and T. D. Spector Heritability of Central Systolic Pressure Augmentation : A Twin Study Hypertension, February 1, 2000; 35(2): 574 - 579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Yasmin and M.J. Brown Similarities and differences between augmentation index and pulse wave velocity in the assessment of arterial stiffness QJM, October 1, 1999; 92(10): 595 - 600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Karamanoglu and M. P. Feneley Late systolic pressure augmentation: role of left ventricular outflow patterns Am J Physiol Heart Circ Physiol, August 1, 1999; 277(2): H481 - H487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Lafleche, B. M. Pannier, B. Laloux, and M. E. Safar Arterial response during cold pressor test in borderline hypertension Am J Physiol Heart Circ Physiol, August 1, 1998; 275(2): H409 - H415. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Stergiopulos, B. E. Westerhof, and N. Westerhof Physical basis of pressure transfer from periphery to aorta: a model-based study Am J Physiol Heart Circ Physiol, April 1, 1998; 274(4): H1386 - H1392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. London, A. P. Guerin, B. Pannier, S. J. Marchais, and M. Stimpel Influence of Sex on Arterial Hemodynamics and Blood Pressure : Role of Body Height Hypertension, September 1, 1995; 26(3): 514 - 519. [Abstract] [Full Text]
|
|
|
|
|
|
M. E. Safar and E. D. Frohlich The Arterial System in Hypertension : A Prospective View Hypertension, July 1, 1995; 26(1): 10 - 14. [Abstract] [Full Text]
|
|
|
|
|
|
P. Boutouyrie, S. Laurent, X. Girerd, A. Benetos, P. Lacolley, E. Abergel, and M. Safar Common Carotid Artery Stiffness and Patterns of Left Ventricular Hypertrophy in Hypertensive Patients Hypertension, April 1, 1995; 25(4): 651 - 659. [Abstract] [Full Text]
|
|