Hypertension, Vol 22, 900-912, Copyright © 1993 by American Heart Association
Y Imai, K Nagai, M Sakuma, H Sakuma, H Nakatsuka, H Satoh, N Minami, M Munakata, J Hashimoto and T Yamagishi
We performed a cross-sectional study in a small town in northern Japan to
evaluate the distribution, reference values, and daily variation in
ambulatory blood pressure. A total of 705 subjects (229 men aged 61.3 +/-
13.4 years [mean +/- SD] and 476 women aged 57.5 +/- 13.3 years; 41.1% of
the regional adult population, n = 1716), including those treated with
antihypertensive drugs (n = 231, 66.5 +/- 9.5 years) as well as untreated
subjects (n = 474, 55.0 +/- 13.5 years), participated in the study. Both
ambulatory and screening blood pressures were measured in 659 subjects.
Ambulatory blood pressure was measured with an automatic device (Colin
ABPM-630). The 24-hour ambulatory blood pressure in the total population
was 121.7 +/- 13.0/71.1 +/- 7.6 mm Hg (95th percentile value [95%] = 146/85
mm Hg). The corresponding value in the untreated subjects was 119.4 +/-
12.5/70.1 +/- 7.4 mm Hg (95% = 144/83 mm Hg). The 24-hour average
ambulatory blood pressure was 118.0 +/- 11.1/69.4 +/- 6.8 mm Hg (95% =
139/81 mm Hg) in subjects identified as normotensive by their screening
blood pressure (n = 448, 57.2 +/- 13.1 years) and 133.6 +/- 14.2/78.9 +/-
8.8 mm Hg in those identified as hypertensive by their screening blood
pressure (n = 73, 63.1 +/- 10.6 years). Based on the mean+SD of the 24-hour
ambulatory blood pressure in the normotensive subjects by their screening
blood pressure (129/76 mm Hg), the 24-hour ambulatory blood pressures in 25
(34.2%) of these 73 hypertensive subjects by screening blood pressure were
below this level. Nine (2%) of 448 normotensive subjects by screening blood
pressure were above the mean+2 SDs (140/83 mm Hg) of the 24-hour ambulatory
blood pressure in the normotensive group by screening blood pressure.
Ambulatory and screening blood pressures increased with age. The
age-dependent increase in ambulatory blood pressure was less apparent in
men. The 24-hour average pulse rate decreased with age. The daily variation
in ambulatory blood pressure (standard deviation) increased with age,
whereas that of pulse rate decreased with age. Increases in blood pressure
variation were observed in nighttime and daytime blood pressure values. The
differences between day versus night ambulatory blood pressures decreased
with age in men but not in women.(ABSTRACT TRUNCATED AT 400 WORDS)
ARTICLES
Ambulatory blood pressure of adults in Ohasama, Japan
Department of Medicine, Tohoku University School of Medicine, Sendai, Japan.
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