Hypertension, Vol 23, 294-301, Copyright © 1994 by American Heart Association
G Grassi, G Seravalle, DA Calhoun and G Mancia
In nine sedentary subjects (16.5 +/- 0.4 years, mean +/- SEM) we measured
blood pressure (Finapres device), heart rate (electrocardiogram), and
postganglionic muscle sympathetic nerve activity (microneurography from the
peroneal nerve) at rest and during intravenous infusion of phenylephrine
and nitroprusside. These measurements were performed before and after 10
weeks of endurance training (2 h/d, 5 d/wk) that increased maximum oxygen
consumption from 34.8 +/- 2.1 to 40.4 +/- 1.8 mL/kg per minute (P <
.02). Basal mean blood pressure and muscle sympathetic nerve activity were
lower after than before endurance training (86.5 +/- 2.6 versus 97.5 +/-
1.8 mm Hg, P < .05, and 14.0 +/- 1.8 versus 21.2 +/- 2.3 bursts per
minute, P < .02), and the changes in these variables were closely
related (r = .95, P < .01). Similar mean blood pressure increases
induced by phenylephrine caused greater reductions in heart rate and muscle
sympathetic nerve activity after than before endurance training (-8.6 +/-
0.8 versus -6.1 +/- 1.1 beats per minute, P = NS, and -78.0 +/- 4.6% versus
-53.6 +/- 4.8%, P < .05). Likewise, similar mean blood pressure
reductions induced by nitroprusside caused greater increases in heart rate
and muscle sympathetic nerve activity after than before endurance training
(18.6 +/- 3.0 versus 12.4 +/- 2.4 beats per minute, P < .05, and 128.1
+/- 26% versus 63.2 +/- 11%, P < .02). No alteration in hemodynamics,
oxygen consumption, muscle sympathetic nerve activity, and baroreceptor
reflex sensitivity occurred in four other age-matched sedentary subjects
studied before and after a 10-week observation period without endurance
training.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Physical training and baroreceptor control of sympathetic nerve activity in humans
Cattedra di Medicina Interna, Osp. S. Gerardo, Monza, Universita di Milano, Italy.
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