Hypertension, Vol 23, 308-312, Copyright © 1994 by American Heart Association
S Bhanot, JH McNeill and M Bryer-Ash
To determine whether insulin resistance and hyperinsulinemia are causally
related to fructose-induced hypertension, we used vanadyl sulfate, a drug
that improves insulin sensitivity in rats. Chronic oral vanadyl treatment
was initiated in 6-week-old male Sprague-Dawley rats. One week after
vanadyl was started, rats were fed either normal rat chow or a
fructose-enriched diet. Plasma glucose and insulin levels and systolic
blood pressure were measured weekly for 4 weeks. Fructose feeding induced
hyperinsulinemia (fructose-fed, 366.6 +/- 8.4 versus control, 276 +/- 10.8
pmol/L, P < .001) and increased blood pressure (fructose-fed, 160 +/-
3.0 versus control, 124 +/- 3.0 mm Hg, P < .001). Vanadyl (0.4 to 0.6
mmol/kg per day) prevented the rise in plasma insulin (treated, 211.2 +/-
6.0 pmol/L, P < .001) and blood pressure (treated, 127 +/- 3.0 mm Hg, P
< .001) in the fructose-fed rats without a change in plasma glucose. No
change in blood pressure was seen in the control group. After 4 weeks,
euglycemic clamps were performed on 20-hour fasted, conscious, mobile rats.
Low-dose porcine insulin infusion (14 pmol/kg per minute) with concomitant
somatostatin infusion resulted in similar steady-state plasma glucose and
insulin levels in the various groups. Hepatic glucose production was
suppressed and similar among various groups under clamp conditions. Insulin
sensitivity index (micromoles of glucose per kilogram per hour per picomole
per liter of insulin) was reduced in the fructose-fed rats compared with
controls (fructose-fed, 0.9 +/- 0.4 versus control, 5.4 +/- 1.2, P <
.002).(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Vanadyl sulfate prevents fructose-induced hyperinsulinemia and hypertension in rats
Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
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