Hypertension, Vol 23, 337-345, Copyright © 1994 by American Heart Association
S Lu, DL Mattson and AW Cowley Jr
We examined the contribution of renal medullary function to the maintenance
of hypertension in spontaneously hypertensive rats by infusing captopril
chronically into the renal medullary interstitial space of
uninephrectomized rats. Changes in cortical and medullary blood flow were
determined using a newly developed optical fiber implantation technique for
laser-Doppler flowmetry. Renal medullary interstitial infusion of captopril
(5 mg/kg per day) selectively increased medullary blood flow by 40% without
altering renal cortical blood flow throughout the 5 days of captopril
delivery. In association with the selective increase of medullary
perfusion, a significant natriuresis was observed on the second day of the
drug infusion, and urine osmolality was significantly reduced during the
first 3 days of captopril infusion. Mean arterial pressure was
significantly decreased by 20 mm Hg during 5 days of captopril infusion,
and the chronic renal function curve was shifted to a lower level of
arterial pressure compared with the control values when 0.9% sodium
chloride saline vehicle was infused. Intravenously infused captopril at 5
mg/kg per day did not alter mean arterial pressure, excluding the
possibility that the hypotensive effect of medullary captopril infusion was
due to recirculation. In summary, chronic reduction of the elevated renal
medullary vascular tone by medullary interstitial infusion of captopril
reset the steady-state renal function curve and lowered arterial pressure
in spontaneously hypertensive rats.
ARTICLES
Renal medullary captopril delivery lowers blood pressure in spontaneously hypertensive rats
Department of Physiology, Medical College of Wisconsin, Milwaukee 53226.
This article has been cited by other articles:
 |
|
 |
|
  A. W. Cowley Jr Renal Medullary Oxidative Stress, Pressure-Natriuresis, and Hypertension Hypertension, November 1, 2008; 52(5): 777 - 786. [Full Text] [PDF]
|
|
|
|
 |
|
 A. W. Cowley Jr., T. Mori, D. Mattson, and A.-P. Zou Role of renal NO production in the regulation of medullary blood flow Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1355 - R1369. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Sarkis, K. L. Liu, M. Lo, and D. Benzoni Angiotensin II and renal medullary blood flow in Lyon rats Am J Physiol Renal Physiol, February 1, 2003; 284(2): F365 - F372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Mattson Importance of the renal medullary circulation in the control of sodium excretion and blood pressure Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2003; 284(1): R13 - R27. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Mangrum, R. A. Gomez, and V. F. Norwood Effects of AT1A receptor deletion on blood pressure and sodium excretion during altered dietary salt intake Am J Physiol Renal Physiol, September 1, 2002; 283(3): F447 - F453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-G. Feng, S. A. W. Dukacz, and R. L. Kline Selective effect of tempol on renal medullary hemodynamics in spontaneously hypertensive rats Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2001; 281(5): R1420 - R1425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. W. Dukacz, M.-G. Feng, L.-F. Yang, R. M. K. W. Lee, and R. L. Kline Abnormal renal medullary response to angiotensin II in SHR is corrected by long-term enalapril treatment Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R1076 - R1084. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Szentivanyi Jr, A.-P. Zou, C. Y. Maeda, D. L. Mattson, and A. W. Cowley Jr Increase in Renal Medullary Nitric Oxide Synthase Activity Protects From Norepinephrine-Induced Hypertension Hypertension, January 1, 2000; 35(1): 418 - 423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Correia, G. Bergstrom, A. J. Lawrence, and R. G. Evans Renal medullary interstitial infusion of norepinephrine in anesthetized rabbits: methodological considerations Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1999; 277(1): R112 - R122. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. GROSS, W. SCHNEIDER, W.-H. SCHUNCK, E. MERVAALA, and F. C. LUFT Chronic Effects of Lovastatin and Bezafibrate on Cortical and Medullary Hemodynamics in Deoxycorticosterone Acetate-Salt Hypertensive Mice J. Am. Soc. Nephrol., July 1, 1999; 10(7): 1430 - 1439. [Abstract] [Full Text]
|
|
|
|
|
|
J. B. O'Sullivan and S. B. Harrap Long-Term Effects of Angiotensin-Converting Enzyme Inhibition on Renal Medullary Neutral Lipid in Spontaneously Hypertensive Rats Hypertension, May 1, 1999; 33(5): 1214 - 1217. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. W. Dukacz, M. A. Adams, and R. L. Kline Short- and long-term enalapril affect renal medullary hemodynamics in the spontaneously hypertensive rat Am J Physiol Regulatory Integrative Comp Physiol, January 1, 1999; 276(1): R10 - R16. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Szentivanyi Jr, C. Y. Maeda, and A. W. Cowley Jr Local Renal Medullary L-NAME Infusion Enhances the Effect of Long-Term Angiotensin II Treatment Hypertension, January 1, 1999; 33(1): 440 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. Cowley Jr., M. M. Skelton, and T. M. Kurth Effects of long-term vasopressin receptor stimulation on medullary blood flow and arterial pressure Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1998; 275(5): R1420 - R1424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Miyata, A. P. Zou, D. L. Mattson, and A. W. Cowley Jr. Renal medullary interstitial infusion of L-arginine prevents hypertension in Dahl salt-sensitive rats Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1998; 275(5): R1667 - R1673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Bergstrom and R. G. Evans Effects of renal medullary infusion of a vasopressin V1 agonist on renal antihypertensive mechanisms in rabbits Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1998; 275(1): R76 - R85. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Gross, T. M. Kurth, M. M. Skelton, D. L. Mattson, and A. W. Cowley Jr. Effects of daily sodium intake and ANG II on cortical and medullary renal blood flow in conscious rats Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1998; 274(5): R1317 - R1323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Disashi, H. Nonoguchi, T. Iwaoka, S. Naomi, Y. Nakayama, K. Shimada, K. Tanzawa, and K. Tomita Endothelin Converting Enzyme-1 Gene Expression in the Kidney of Spontaneously Hypertensive Rats Hypertension, December 1, 1997; 30(6): 1591 - 1597. [Abstract] [Full Text]
|
|
|
|
|
|
F. Park, D. L. Mattson, L. A. Roberts, and A. W. Cowley Jr. Evidence for the presence of smooth muscle alpha -actin within pericytes of the renal medulla Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1997; 273(5): R1742 - R1748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Jiang and R. J. Roman Lovastatin Prevents Development of Hypertension in Spontaneously Hypertensive Rats Hypertension, October 1, 1997; 30(4): 968 - 974. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. Haugan, M. Shalmi, J. S. Petersen, N. Marcussen, J. Spannow, and S. Christensen Effects of Renal Papillary-Medullary Lesion on the Antihypertensive Effect of Furosemide and Development of Salt-Sensitive Hypertension in Dahl-S Rats J. Pharmacol. Exp. Ther., March 1, 1997; 280(3): 1415 - 1422. [Abstract] [Full Text]
|
|
|
|
|
|
L.-X. Zou, J. D. Imig, A. M. Von Thun, A. Hymel, H. Ono, and L. G. Navar Receptor-Mediated Intrarenal Angiotensin II Augmentation in Angiotensin II–Infused Rats Hypertension, October 1, 1996; 28(4): 669 - 677. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. W. Cowley Jr and R. J. Roman The Role of the Kidney in Hypertension JAMA, May 22, 1996; 275(20): 1581 - 1589. [Abstract] [PDF]
|
|
|
|
|
|
M. C. Ortiz, N. M. Atucha, V. Lahera, F. Vargas, T. Quesada, and J. Garcia-Estan Importance of Nitric Oxide and Prostaglandins in the Control of Rat Renal Papillary Blood Flow Hypertension, March 1, 1996; 27(3): 377 - 381. [Abstract] [Full Text]
|
|
|
|
|
|
N. Bouby, L. Bankir, and C. Llorens-Cortes Type 1 Angiotensin II Receptor Subtypes in Kidney of Normal and Salt-Sensitive Hypertensive Rats Hypertension, March 1, 1996; 27(3): 392 - 398. [Abstract] [Full Text]
|
|
|
|
|
|
V. Cachofeiro, R. Maeso, E. Rodrigo, J. Navarro, L. M. Ruilope, and V. Lahera Nitric Oxide and Prostaglandins in the Prolonged Effects of Losartan and Ramipril in Hypertension Hypertension, August 1, 1995; 26(2): 236 - 243. [Abstract] [Full Text]
|
|
|
|
|
|
A. W. Cowley Jr, D. L. Mattson, S. Lu, and R. J. Roman The Renal Medulla and Hypertension Hypertension, April 1, 1995; 25(4): 663 - 673. [Abstract] [Full Text]
|
|
|
|
|
|
F. J. Fenoy, P. Ferrer, L. Carbonell, and M. Garcia-Salom Role of Nitric Oxide on Papillary Blood Flow and Pressure Natriuresis Hypertension, March 1, 1995; 25(3): 408 - 414. [Abstract] [Full Text]
|
|