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Hypertension, Vol 23, 395-401, Copyright © 1994 by American Heart Association
S Madhavan, WL Ooi, H Cohen and MH Alderman
The prognostic value of pretreatment pulse pressure as a predictor of
myocardial infarction and the relation of pulse pressure and in- treatment
diastolic blood pressure reduction to myocardial infarction were
investigated in a union-sponsored systematic hypertension control program.
In a prospective study, 2207 hypertensive patients with a pretreatment
systolic blood pressure greater than or equal to 160 mm Hg and/or diastolic
pressure greater than or equal to 95 mm Hg grouped according to tertile of
pulse pressure (PP1, < or = 46; PP2, 47 to 62; PP3, > or = 63 mm Hg)
were further stratified by the degree of diastolic fall: large (L), > or
= 18; moderate (M), 7 to 17; small (S), < or = 6 mm Hg. During an
average follow-up of 5 years, 132 cardiovascular events (50 myocardial
infarctions, 23 strokes) were observed. Myocardial infarction rates per
1000 person-years were positively related to pulse pressure (PP1, 3.5; PP2,
2.9; PP3, 7.5; PP3 versus PP1, P = .02). Wide pulse pressure was identified
as a predictor of myocardial infarction (PP3 versus [PP1 + PP2]: relative
risk [RR] = 2.2, 95% confidence interval [CI] = 1.2-4.1), controlling for
other known risk factors by Cox regression. A curvilinear relation
(resembling a J shape) between diastolic fall and myocardial infarction was
observed in patients with the widest pulse pressure, PP3 (L, 9.5; M, 3.9;
S, 11.2; L versus M: RR = 2.5, 95% CI = 1.0-6.2; S versus M: RR = 2.9, 95%
CI = 1.1-8.0).(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Relation of pulse pressure and blood pressure reduction to the incidence of myocardial infarction
Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY 10461.
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J.-G. Wang, J. A. Staessen, L. Gong, L. Liu, and for the Systolic Hypertension in China Collaborat Chinese Trial on Isolated Systolic Hypertension in the Elderly Arch Intern Med, January 24, 2000; 160(2): 211 - 220. [Abstract] [Full Text] [PDF]
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P. Boutouyrie, C. Bussy, P. Lacolley, X. Girerd, B. Laloux, and S. Laurent Association Between Local Pulse Pressure, Mean Blood Pressure, and Large-Artery Remodeling Circulation, September 28, 1999; 100(13): 1387 - 1393. [Abstract] [Full Text] [PDF]
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M. O'Rourke and E. D. Frohlich Pulse Pressure : Is This a Clinically Useful Risk Factor? Hypertension, September 1, 1999; 34(3): 372 - 374. [Full Text] [PDF]
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M. J. Domanski, B. R. Davis, M. A. Pfeffer, M. Kastantin, and G. F. Mitchell Isolated Systolic Hypertension : Prognostic Information Provided by Pulse Pressure Hypertension, September 1, 1999; 34(3): 375 - 380. [Abstract] [Full Text] [PDF]
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H. R. Black The Paradigm Has Shifted, to Systolic Blood Pressure Hypertension, September 1, 1999; 34(3): 386 - 387. [Full Text] [PDF]
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S. S. Franklin, S. A. Khan, N. D. Wong, M. G. Larson, and D. Levy Is Pulse Pressure Useful in Predicting Risk for Coronary Heart Disease? : The Framingham Heart Study Circulation, July 27, 1999; 100(4): 354 - 360. [Abstract] [Full Text] [PDF]
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T. A. Lakka, R. Salonen, G. A. Kaplan, and J. T. Salonen Blood Pressure and the Progression of Carotid Atherosclerosis in Middle-Aged Men Hypertension, July 1, 1999; 34(1): 51 - 56. [Abstract] [Full Text] [PDF]
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G. E. McVeigh, C. W. Bratteli, D. J. Morgan, C. M. Alinder, S. P. Glasser, S. M. Finkelstein, and J. N. Cohn Age-Related Abnormalities in Arterial Compliance Identified by Pressure Pulse Contour Analysis : Aging and Arterial Compliance Hypertension, June 1, 1999; 33(6): 1392 - 1398. [Abstract] [Full Text] [PDF]
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J. Topouchian, R. Asmar, F. Sayegh, A. Rudnicki, A. Benetos, A. M. Bacri, and M. E. Safar Changes in Arterial Structure and Function Under Trandolapril-Verapamil Combination in Hypertension Stroke, May 1, 1999; 30(5): 1056 - 1064. [Abstract] [Full Text] [PDF]
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M. J. Domanski, G. F. Mitchell, J. E. Norman, D. V. Exner, B. Pitt, and M. A. Pfeffer Independent prognostic information provided by sphygmomanometrically determined pulse pressure and mean arterial pressure in patients with left ventricular dysfunction J. Am. Coll. Cardiol., March 15, 1999; 33(4): 951 - 958. [Abstract] [Full Text] [PDF]
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M. Zureik, P.-J. Touboul, C. Bonithon-Kopp, D. Courbon, C. Berr, C. Leroux, and P. Ducimetiere Cross-Sectional and 4-Year Longitudinal Associations Between Brachial Pulse Pressure and Common Carotid Intima-Media Thickness in a General Population : The EVA Study Stroke, March 1, 1999; 30(3): 550 - 555. [Abstract] [Full Text] [PDF]
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G. de Simone, M. J. Roman, M. J. Koren, G. A. Mensah, A. Ganau, and R. B. Devereux Stroke Volume/Pulse Pressure Ratio and Cardiovascular Risk in Arterial Hypertension Hypertension, March 1, 1999; 33(3): 800 - 805. [Abstract] [Full Text] [PDF]
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C. U. Chae, M. A. Pfeffer, R. J. Glynn, G. F. Mitchell, J. O. Taylor, and C. H. Hennekens Increased Pulse Pressure and Risk of Heart Failure in the Elderly JAMA, February 17, 1999; 281(7): 634 - 643. [Abstract] [Full Text] [PDF]
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A. Benetos, A. Rudnichi, F. Thomas, M. Safar, and L. Guize Influence of Heart Rate on Mortality in a French Population : Role of Age, Gender, and Blood Pressure Hypertension, January 1, 1999; 33(1): 44 - 52. [Abstract] [Full Text] [PDF]
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P. Verdecchia, G. Schillaci, C. Borgioni, A. Ciucci, S. Pede, and C. Porcellati Ambulatory Pulse Pressure : A Potent Predictor of Total Cardiovascular Risk in Hypertension Hypertension, December 1, 1998; 32(6): 983 - 988. [Abstract] [Full Text] [PDF]
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A. Benetos, A. Rudnichi, M. Safar, and L. Guize Pulse Pressure and Cardiovascular Mortality in Normotensive and Hypertensive Subjects Hypertension, September 1, 1998; 32(3): 560 - 564. [Abstract] [Full Text] [PDF]
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J. Blacher, B. Pannier, A. P. Guerin, S. J. Marchais, M. E. Safar, and G. M. London Carotid Arterial Stiffness as a Predictor of Cardiovascular and All-Cause Mortality in End-Stage Renal Disease Hypertension, September 1, 1998; 32(3): 570 - 574. [Abstract] [Full Text] [PDF]
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J. A. Staessen, R. Fagard, L. Thijs, H. Celis, W. H. Birkenhager, C. J. Bulpitt, P. W. de Leeuw, A. E. Fletcher, M.-R. Babarskiene, F. Forette, et al. Subgroup and Per-Protocol Analysis of the Randomized European Trial on Isolated Systolic Hypertension in the Elderly Arch Intern Med, August 10, 1998; 158(15): 1681 - 1691. [Abstract] [Full Text]
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M. E. Safar, G. M. London, R. Asmar, and E. D. Frohlich Recent Advances on Large Arteries in Hypertension Hypertension, July 1, 1998; 32(1): 156 - 161. [Abstract] [Full Text] [PDF]
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G. F. Mitchell, L. A. Moye, E. Braunwald, J.-L. Rouleau, V. Bernstein, E. M. Geltman, G. C. Flaker, M. A. Pfeffer, and f. t. S. Investigators Sphygmomanometrically Determined Pulse Pressure Is a Powerful Independent Predictor of Recurrent Events After Myocardial Infarction in Patients With Impaired Left Ventricular Function Circulation, December 16, 1997; 96(12): 4254 - 4260. [Abstract] [Full Text]
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A. Benetos, M. Safar, A. Rudnichi, H. Smulyan, J.-L. Richard, P. Ducimetiere, and L. Guize Pulse Pressure : A Predictor of Long-term Cardiovascular Mortality in a French Male Population Hypertension, December 1, 1997; 30(6): 1410 - 1415. [Abstract] [Full Text]
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The Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure Arch Intern Med, November 24, 1997; 157(21): 2413 - 2446. [Abstract] [PDF]
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A. Benetos, F. Cambien, S. Gautier, S. Ricard, M. Safar, S. Laurent, P. Lacolley, O. Poirier, J. Topouchian, and R. Asmar Influence of the Angiotensin II Type 1 Receptor Gene Polymorphism on the Effects of Perindopril and Nitrendipine on Arterial Stiffness in Hypertensive Individuals Hypertension, December 1, 1996; 28(6): 1081 - 1084. [Abstract] [Full Text]
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H. R. Black and J.-Y. Yi A New Classification Scheme for Hypertension Based on Relative and Absolute Risk With Implications for Treatment and Reimbursement Hypertension, November 1, 1996; 28(5): 719 - 724. [Abstract] [Full Text]
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D. K. Arnett, H. A. Tyroler, G. Burke, R. Hutchinson, G. Howard, and G. Heiss Hypertension and Subclinical Carotid Artery Atherosclerosis in Blacks and Whites: The Atherosclerosis Risk in Communities Study Arch Intern Med, September 23, 1996; 156(17): 1983 - 1989. [Abstract] [PDF]
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