Hypertension, Vol 23, 587-592, Copyright © 1994 by American Heart Association
AD Everett, A Tufro-McReddie, A Fisher and RA Gomez
The role of angiotensin II via the angiotensin type 1 or type 2 receptor in
the development of cardiac hypertrophy was determined in adult male
Sprague-Dawley rats subjected to coarctation of the abdominal aorta. Five
groups of animals were studied: coarctation, coarctation plus DuP 753,
coarctation plus PD 123319, sham plus DuP 753, or sham operation. Type 1
receptor blockade was accomplished with DuP 753 given in the drinking water
and type 2 blockade with PD 123319 delivered by osmotic minipumps beginning
with the day of surgery until 72 hours after aortic coarctation. Mean
carotid blood pressures and the carotid-femoral artery blood pressure
gradients were not different among coarctation, coarctation plus DuP 753,
and coarctation plus PD 123319 animals. However, ratios of heart weight to
body weight were higher in coarctation (4.95 +/- 0.8) or coarctation plus
PD 123319 (4.52 +/- 0.5) than in sham animals (3.6 +/- 0.4; P < .005 and
.05, respectively). In coarctation plus DuP 753-treated animals heart
weight- body weight ratios were not different from sham or sham plus DuP
753 animals (3.9 +/- 0.4 versus 3.6 +/- 0.4 or 3.3 +/- 0.08, respectively).
Type 1 receptor mRNA levels were significantly increased in the coarctation
group, with the highest levels in the coarctation plus DuP 753 and sham
plus DuP 753 groups. To determine whether growth factors were involved in
the hypertrophic process, we measured transforming growth factor-beta 1
mRNA levels. Northern analysis demonstrated a twofold increase in
coarctation animals compared with sham or coarctation plus DuP 753-treated
animals.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Angiotensin receptor regulates cardiac hypertrophy and transforming growth factor-beta 1 expression
University of Virginia Health Sciences Center, Department of Pediatrics, Charlottesville 22908.
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