Hypertension, Vol 23, 600-606, Copyright © 1994 by American Heart Association
G de Simone, RB Devereux, MJ Roman, MH Alderman and JH Laragh
Although it is recognized that both hypertension and obesity are associated
with increased left ventricular mass, the relative impacts of obesity,
arterial hypertension, and gender on the prevalence of ventricular
hypertrophy remain uncertain. Accordingly, echocardiographic left
ventricular mass normalized for height to the power of the allometric or
growth relation between ventricular mass and height was compared in 164
normotensive subjects (85 men [24 obese] and 79 women [28 obese], aged 45
+/- 12 years) and 475 hypertensive patients (325 men [126 obese] and 150
women [85 obese], aged 54 +/- 10 years) from an adult employed population.
Gender-specific upper normal limits were used to identify ventricular
hypertrophy. Left ventricular mass/height 2.7 was higher in obese than
normal-weight normotensive subjects (P < .004) independently of the
level of blood pressure and identified a higher prevalence of hypertrophy
(mainly eccentric) in obese than in normal-weight normotensive subjects
(14% versus 5%, P < .04), a difference that was not detected by left
ventricular mass/body surface area. Left ventricular mass/height identified
hypertrophy in 52% of obese and 30% of normal-weight hypertensive patients
(P < .0001) because of higher prevalences in obese than normal-weight
patients of both eccentric (34% versus 20%) and concentric ventricular
hypertrophy (18% versus 10%). The increase in left ventricular mass was
independent of blood pressure values in obese normotensive women (but not
men), and the prevalence of supranormal left ventricular mass/height 2.7
was even higher in hypertensive obese women (58%) than men (49%).(ABSTRACT
TRUNCATED AT 250 WORDS)
ARTICLES
Relation of obesity and gender to left ventricular hypertrophy in normotensive and hypertensive adults
Division of Cardiology, New York Hospital-Cornell Medical Center, NY 10021.
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|
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|
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