This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gong, G. Articles by Pettinger, W. A. Search for Related Content PubMed PubMed Citation Articles by Gong, G. Articles by Pettinger, W. A.

Hypertension, Vol 23, 607-612, Copyright © 1994 by American Heart Association

ARTICLES

Sex influence on renal alpha 2-adrenergic receptor density in the spontaneously hypertensive rat

G Gong, A Dobin, S McArdle, L Sun, ML Johnson and WA Pettinger
Department of Medicine, Creighton University School of Medicine, Omaha, Neb. 68131.

Male spontaneously hypertensive rats (SHR) have higher blood pressure than females. We compared renal alpha 2-adrenergic receptor density among intact SHR and Wistar-Kyoto (WKY) rats of both sexes, male and female SHR gonadectomized at 4 weeks of age, and gonadectomized SHR supplemented with testosterone. Additional groups of SHR were treated with enalapril (30 mg/kg per day), an angiotensin-converting enzyme inhibitor, from 5 to 14 weeks of age. Renal alpha 2-adrenergic receptor density was higher in males than females in both SHR and WKY rats. Female SHR and WKY rats had identical low renal alpha 2-adrenergic receptor density. Castration of male SHR reduced the male-female differences in blood pressure and renal alpha 2-adrenergic receptor density by 60%. Treatment with testosterone raised blood pressure and renal alpha 2-adrenergic receptor density to the intact male levels in both gonadectomized males and females. Treatment with enalapril decreased blood pressure but not renal alpha 2-adrenergic receptor density in both male and female SHR. We conclude that (1) both renal alpha 2-adrenergic receptor density and blood pressure are influenced by sex in SHR and WKY, (2) renal alpha 2-adrenergic receptor density like blood pressure is regulated by androgens, and (3) increased renal alpha 2-adrenergic receptor density is not a consequence of high blood pressure in male SHR.

This article has been cited by other articles:

				S. McMullen and S. C. Langley-Evans Sex-Specific Effects of Prenatal Low-Protein and Carbenoxolone Exposure on Renal Angiotensin Receptor Expression in Rats Hypertension, December 1, 2005; 46(6): 1374 - 1380. [Abstract] [Full Text] [PDF]

				G. Coatmellec-Taglioni, J.-P. Dausse, Y. Giudicelli, and C. Ribiere Sexual Dimorphism in Cafeteria Diet-Induced Hypertension Is Associated with Gender-Related Difference in Renal Leptin Receptor Down-Regulation J. Pharmacol. Exp. Ther., April 1, 2003; 305(1): 362 - 367. [Abstract] [Full Text]

				M. Khalid, N. Ilhami, Y. Giudicelli, and J.-P. Dausse Testosterone Dependence of Salt-Induced Hypertension in Sabra Rats and Role of Renal alpha 2-Adrenoceptor Subtypes J. Pharmacol. Exp. Ther., January 1, 2002; 300(1): 43 - 49. [Abstract] [Full Text] [PDF]

				M. Khalid, Y. Giudicelli, and J.-P. Dausse An Up-Regulation of Renal alpha 2A-Adrenoceptors Is Associated with Resistance to Salt-Induced Hypertension in Sabra Rats J. Pharmacol. Exp. Ther., December 1, 2001; 299(3): 928 - 933. [Abstract] [Full Text] [PDF]

				A. Caplea, D. Seachrist, G. Dunphy, and D. Ely Sodium-induced rise in blood pressure is suppressed by androgen receptor blockade Am J Physiol Heart Circ Physiol, April 1, 2001; 280(4): H1793 - H1801. [Abstract] [Full Text] [PDF]

				D. Ely, A. Caplea, G. Dunphy, H. Daneshvar, M. Turner, A. Milsted, and M. Takiyyuddin Spontaneously Hypertensive Rat Y Chromosome Increases Indexes of Sympathetic Nervous System Activity Hypertension, February 1, 1997; 29(2): 613 - 618. [Abstract] [Full Text]

				J. Alfie, G. D. Waisman, C. R. Galarza, M. I. Magi, F. Vasvari, L. M. Mayorga, and M. I. Camera Relationship Between Systemic Hemodynamics and Ambulatory Blood Pressure Level Are Sex Dependent Hypertension, December 1, 1995; 26(6): 1195 - 1199. [Abstract] [Full Text]

				G. Gong, M. L. Johnson, and W. A. Pettinger Testosterone Regulation of Renal {alpha}2B-Adrenergic Receptor mRNA Levels Hypertension, March 1, 1995; 25(3): 350 - 355. [Abstract] [Full Text]