Hypertension, Vol 23, 729-736, Copyright © 1994 by American Heart Association
AR Dyer, P Elliott, M Shipley, R Stamler and J Stamler
This report further examines the relation of body mass index (BMI) to
associations of 24-hour urinary sodium, potassium, and sodium-potassium
ratio with blood pressure in INTERSALT, a 52-center international study of
electrolytes and blood pressure. Analyses without adjustment for BMI
indicated average systolic pressure greater by 6.00 mm Hg per 100 mmol
higher sodium and diastolic by 2.52 mm Hg. With adjustment for BMI, these
values were reduced to 3.14 and 0.14 mm Hg, respectively. For the
sodium-potassium ratio, blood pressure associations were stronger when not
adjusted for BMI, and for potassium, adjustment generally had little
effect. To explore possible interactions of these variables with BMI in
relation to blood pressure, the 52 centers were divided into two groups of
26 based on whether the center median for BMI was less than or greater than
or equal to 24.5 kg/m2, and individuals within each of the 52 centers were
classified into lower- or higher-BMI groups based on individual BMI less
than or greater than or equal to 24.1 kg/m2. Sodium and the
sodium-potassium ratio were positively and significantly and potassium
inversely and significantly related to systolic pressure in all four of
these subgroups, and the sodium-potassium ratio and potassium were related
to diastolic pressure in two and three subgroups, respectively.
Electrolyte-blood pressure associations did not differ significantly
between the two subgroups of centers or between the two subgroups based on
individuals.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Body mass index and associations of sodium and potassium with blood pressure in INTERSALT
Department of Preventive Medicine, Northwestern University Medical School, Chicago, Ill. 60611.
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