Hypertension, Vol 23, 752-756, Copyright © 1994 by American Heart Association
H Hayakawa, Y Hirata, E Suzuki, K Kimura, K Kikuchi, T Nagano, M Hirobe and M Omata
To examine the effects of L-arginine (L-Arg) on endothelial function, we
administered 0.5 g/L L-Arg in drinking water to deoxycorticosterone acetate
(DOCA)-salt rats for 8 weeks and then measured nitric oxide (NO) release
from isolated kidneys using a newly developed real-time chemiluminescence
method. Renal pathology was also analyzed. Acetylcholine caused much
smaller declines in renal perfusion pressure (10(-7) mol/L acetylcholine:
-24 +/- 2% [SEM] versus -50 +/- 2%, P < .001) and NO release in
DOCA-salt rats (+3 +/- 1 versus +33 +/- 3 fmol/min per gram kidney weight,
P < .001) compared with control rats. L-Arg did not influence the time
course of systolic blood pressure elevation in DOCA-salt rats (211 +/- 5
versus 208 +/- 6 mmHg, DOCA versus L-Arg/DOCA, P = NS). However, oral
administration of L-Arg improved acetylcholine-induced declines in renal
perfusion pressure (10(-7) mol/L acetylcholine: L-Arg/DOCA, -39 +/- 3%, P
< .01 versus DOCA). This change was associated with an increase in NO
release by acetylcholine (10(-7) mol/L acetylcholine: L-Arg/DOCA, +10 +/- 1
fmol/min per gram kidney weight, P < .05 versus DOCA). However,
morphological changes in renal vessels and glomeruli were similar between
DOCA and L-Arg/DOCA rats. These results suggest that L-Arg administration
partially reverses renal endothelial function with respect to
vasorelaxation and NO release independent of blood pressure changes,
indicating that hypertensive vessels seem to be depleted of L- Arg and/or
have defects in the availability of L-Arg for NO synthesis.
ARTICLES
Long-term administration of L-arginine improves nitric oxide release from kidney in deoxycorticosterone acetate-salt hypertensive rats
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
This article has been cited by other articles:
 |
|
 |
|
  M. Carlstrom, R. D. Brown, J. Edlund, J. Sallstrom, E. Larsson, T. Teerlink, F. Palm, N. Wahlin, and A. E. G. Persson Role of nitric oxide deficiency in the development of hypertension in hydronephrotic animals Am J Physiol Renal Physiol, February 1, 2008; 294(2): F362 - F370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Schneider, E. W. Inscho, and D. M. Pollock Attenuated vasoconstrictor responses to endothelin in afferent arterioles during a high-salt diet Am J Physiol Renal Physiol, April 1, 2007; 292(4): F1208 - F1214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Vargas, J. M. Moreno, R. Wangensteen, I. Rodriguez-Gomez, and J. Garcia-Estan The endocrine system in chronic nitric oxide deficiency Eur. J. Endocrinol., January 1, 2007; 156(1): 1 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kakoki, H.-S. Kim, C.-J. S. Edgell, N. Maeda, O. Smithies, and D. L. Mattson Amino acids as modulators of endothelium-derived nitric oxide Am J Physiol Renal Physiol, August 1, 2006; 291(2): F297 - F304. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Yagil, N. Hubner, J. Monti, H. Schulz, M. Sapojnikov, F. C. Luft, D. Ganten, and Y. Yagil Identification of Hypertension-Related Genes Through an Integrated Genomic-Transcriptomic Approach Circ. Res., April 1, 2005; 96(6): 617 - 625. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kakoki, H.-S. Kim, W. J. Arendshorst, and D. L. Mattson L-Arginine uptake affects nitric oxide production and blood flow in the renal medulla Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2004; 287(6): R1478 - R1485. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Cherla and E. A. Jaimes Role of L-Arginine in the Pathogenesis and Treatment of Renal Disease J. Nutr., October 1, 2004; 134(10): 2801S - 2806S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Shindo, Y. Kurihara, H. Nishimatsu, N. Moriyama, M. Kakoki, Y. Wang, Y. Imai, A. Ebihara, T. Kuwaki, K.-H. Ju, et al. Vascular Abnormalities and Elevated Blood Pressure in Mice Lacking Adrenomedullin Gene Circulation, October 16, 2001; 104(16): 1964 - 1971. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Alvarez, A. Osuna, R. Wangensteen, and F. Vargas Interaction Between Nitric Oxide and Mineralocorticoids in the Long-Term Control of Blood Pressure Hypertension, March 1, 2000; 35(3): 752 - 757. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hayakawa and L. Raij Nitric Oxide Synthase Activity and Renal Injury in Genetic Hypertension Hypertension, January 1, 1998; 31(1): 266 - 270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hirata, H. Hayakawa, M. Kakoki, A. Tojo, E. Suzuki, D. Nagata, K. Kimura, A. Goto, K. Kikuchi, T. Nagano, et al. Receptor Subtype for Vasopressin-Induced Release of Nitric Oxide From Rat Kidney Hypertension, January 1, 1997; 29(1): 58 - 64. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Hirata, H. Hayakawa, M. Kakoki, A. Tojo, E. Suzuki, K. Kimura, A. Goto, K. Kikuchi, T. Nagano, M. Hirobe, et al. Nitric Oxide Release From Kidneys of Hypertensive Rats Treated With Imidapril Hypertension, March 1, 1996; 27(3): 672 - 678. [Abstract] [Full Text]
|
|
|
|
|
|
J.-S. Jin and L. G. D'Alecy Stimulation of Endogenous Nitric Oxide Pathway by L-Arginine Reduces Declamp Mortality and Attenuates Hypertension Associated With Aortic Cross-Clamp–Induced Hindlimb Ischemia in Rats Hypertension, September 1, 1995; 26(3): 406 - 412. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Hirata, H. Hayakawa, Y. Suzuki, E. Suzuki, H. Ikenouchi, O. Kohmoto, K. Kimura, K. Kitamura, T. Eto, K. Kangawa, et al. Mechanisms of Adrenomedullin-Induced Vasodilation in the Rat Kidney Hypertension, April 1, 1995; 25(4): 790 - 795. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Hirata, H. Hayakawa, E. Suzuki, K. Kimura, K. Kikuchi, T. Nagano, M. Hirobe, and M. Omata Direct Measurements of Endothelium-Derived Nitric Oxide Release by Stimulation of Endothelin Receptors in Rat Kidney and Its Alteration in Salt-Induced Hypertension Circulation, February 15, 1995; 91(4): 1229 - 1235. [Abstract] [Full Text]
|
|