Hypertension, Vol 23, 819-822, Copyright © 1994 by American Heart Association
JN Wu, D Edwards and KH Berecek
We tested the hypothesis that in utero treatment with the angiotensin-
converting enzyme inhibitor captopril could change the affinity, density,
and/or subtypes of angiotensin II (Ang II) receptors in the kidneys of
spontaneously hypertensive rats (SHR). Newborn, 7-day-old, and 4-month-old
SHR and Wistar-Kyoto (WKY) rats were used. SHR and WKY rat breeders were
treated with captopril (0.4 mg/mL, 100 mg/kg per day) in drinking water,
and their pups were maintained on captopril treatment until
experimentation. Control groups were untreated, age- matched SHR and WKY
rats. The density, affinity, and subtypes of renal Ang II receptors were
determined using radioligand binding techniques and receptor antagonists
specific for Ang II receptor subtypes 1 and 2 (losartan, an AT1-specific
antagonist, and CGP 42112B, an AT2-specific antagonist). AT1 receptor
density in kidneys was higher than AT2 receptor density in both neonatal
and adult rats. AT1 receptor density in kidneys increased approximately
twofold from birth to 7 days of age in all groups. Newborn and 7-day-old
SHR showed significantly greater Ang II receptor densities in kidneys than
other rat groups because of significantly greater densities of both AT1 and
AT2 receptors. At 4 months of age, there were no significant differences in
Ang II receptor densities in kidneys between captopril-treated and control
SHR. Our data indicate that the expression of AT1 and AT2 receptors in
kidneys is differentially regulated during development. Enhanced activity
of the renal renin-Ang II system in newborn and probably fetal SHR may be
involved in the pathogenesis of hypertension.(ABSTRACT TRUNCATED AT 250
WORDS)
ARTICLES
Changes in renal angiotensin II receptors in spontaneously hypertensive rats by early treatment with the angiotensin-converting enzyme inhibitor captopril
Department of Physiology and Biophysics, University of Alabama at Birmingham 35294.
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