Hypertension, Vol 23, 878-883, Copyright © 1994 by American Heart Association
S Laurent, B Caviezel, L Beck, X Girerd, E Billaud, P Boutouyrie, A Hoeks and M Safar
Whether the decrease in large-artery distensibility observed in
hypertensive patients is due primarily to an increase in distending
pressure or to hypertension-induced changes in structural properties has
been much debated. We determined noninvasively the diameter- pressure curve
of the common carotid artery over the systolic-diastolic range by
continuously recording both the pulsatile changes in internal diameter
(high-resolution echo-tracking system) and, simultaneously on the
contralateral artery, the pressure waveform (high-fidelity applanation
tonometry). We then derived the distensibility/pressure curve and compared
arterial distensibility in 14 normotensive subjects and 15 age- and
sex-matched hypertensive subjects at their respective mean arterial
pressures (MAP) and at a common distending pressure: 100 mm Hg.
Distensibility decreased as blood pressure increased, and distensibility at
MAP was significantly lower in hypertensive than in normotensive subjects
(7.8 +/- 0.7 versus 11.7 +/- 1.7 kPa-1.10(-3), mean +/- SEM; P < .05).
In hypertensive subjects, the distensibility- pressure curve was shifted
toward higher levels of blood pressure, and a large part of the curve
overlapped that of normotensive subjects. No significant downward shift of
the distensibility-pressure curve was observed in hypertensive subjects,
and distensibility at 100 mm Hg was not significantly different from that
of normotensive subjects (10.0 +/- 1.0 versus 9.0 +/- 1.1 kPa-1.10(-3)).
Distensibility at 100 mm Hg decreased with aging (P < .05) and was not
reduced in hypertensive subjects compared with normotensive subjects after
adjustment for age.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Carotid artery distensibility and distending pressure in hypertensive humans
Department of Pharmacology, Broussais Hospital, Paris, France.
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