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Hypertension, Vol 24, 120-130, Copyright © 1994 by American Heart Association
DP Veerman, BP Imholz, W Wieling, JM Karemaker and GA van Montfrans
The objective of this study was to determine the effect of aging on
beat-to-beat blood pressure and pulse interval variability in resting
conditions and to determine the effect of aging on the sympathetic and
vagal influence on the cardiovascular system by power spectral analysis of
blood pressure and pulse interval. We studied three groups of healthy,
normotensive subjects: young (10 to 15 years, n = 16), adult (20 to 40
years, n = 16), and elderly (70 to 90 years, n = 25). Beat-to- beat blood
pressure was measured by Finapres during 20 minutes supine and 10 minutes
standing. Overall systolic and diastolic blood pressures and pulse interval
variability were determined as SD and as coefficient of variation. Also,
relative powers of the mid-frequency (0.08 to 0.12 Hz) and high-frequency
bands (0.15 to 0.40 Hz) were determined by spectral analysis. In these
subjects no differences in blood pressure variability (either as SD or
coefficient of variation) were found between age groups, except for the
coefficient of variation of standing diastolic blood pressure, which
decreased with aging. Pulse interval variability decreased with aging.
Power of the mid-frequency band of systolic and diastolic blood pressures
was markedly decreased in the elderly, especially in the standing position.
Power of the high- frequency band of pulse interval was also decreased in
the elderly. Baroreflex sensitivity calculated by fast Fourier
transformation spectral analysis was decreased in the elderly subjects
compared with the younger groups. In conclusion, we found no change in the
overall variability of blood pressure with aging. Mid-frequency spectral
power of blood pressure and mid- and high-frequency spectral powers of
pulse interval variability were decreased in the elderly. These results
suggest that aging does not merely influence the magnitude of blood
pressure and pulse interval variability but causes a complex rearrangement
of the variability pattern by changes in neurocardiovascular regulation.
ARTICLES
Effects of aging on blood pressure variability in resting conditions
Department of Medicine, Academic Medical Centre, Amsterdam, The Netherlands.
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