Hypertension, Vol 24, 16-23, Copyright © 1994 by American Heart Association
BJ Falloon and AM Heagerty
To simulate in vivo conditions as closely as possible to in vitro
conditions, we examined the morphological and functional characteristics of
isolated human subcutaneous small arteries from 17 essential hypertensive
patients and 14 normotensive control subjects using a perfusion myograph.
Vessel segments were cannulated and exposed to conditions of constant flow
and pressure. The ratio of media thickness to lumen diameter in arteries
from hypertensive patients increased significantly. With the endothelium
intact, sensitivity to extraluminally applied norepinephrine was not
different, and this was not affected by inhibition of neuronal amine uptake
with cocaine. After removal of the endothelium, sensitivity to
norepinephrine was augmented in normotensive vessels to a greater extent
than in hypertensive vessels. Endothelium-dependent relaxation to
acetylcholine was significantly reduced in arteries from hypertensive
patients, but endothelium-independent relaxation to sodium nitroprusside
was not different from that observed in vessels from normotensive control
subjects. These data demonstrate that sensitivity to exogenous
norepinephrine is not different in essential hypertension but that there is
defective endothelium-dependent dilatation, suggesting a contributory role
for endothelium dysfunction in human essential hypertension.
ARTICLES
In vitro perfusion studies of human resistance artery function in essential hypertension
Department of Medicine, University of Manchester, UK.
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