Hypertension, Vol 24, 63-69, Copyright © 1994 by American Heart Association
A Bonnardeaux, E Davies, X Jeunemaitre, I Fery, A Charru, E Clauser, L Tiret, F Cambien, P Corvol and F Soubrier
We conducted the present study to determine whether the angiotensin II type
I receptor (AT1) gene might be implicated in human essential hypertension
by using case-control and linkage studies. The entire coding and 3'
untranslated regions of the AT1 receptor gene (2.2 kb) were amplified by
polymerase chain reaction and submitted to single- strand conformation
polymorphism in 60 hypertensive subjects with a familial susceptibility. We
identified five polymorphisms (T573-->C, A1062-->G, A1166-->C,
G1517-->T, and A1878-->G). However, no mutations that alter the
encoded amino acid sequence were detected. A case- control study performed
on white hypertensive (n = 206; blood pressure, 168 +/- 16/103 +/- 9 mm Hg)
and normotensive (n = 298; blood pressure, 122 +/- 10/75 +/- 9 mm Hg)
subjects using three of five polymorphisms showed a significant increase in
allelic frequency of C1166 in hypertensive subjects (0.36 versus 0.28 for
normotensive subjects, chi 2 = 6.8, P < .01). Frequencies for the
alleles of the other two polymorphisms (T573-->C, A1878-->G) were
similar in both groups. We performed a linkage study using the affected sib
pair method and a highly polymorphic marker of the AT1 receptor gene. There
was no evidence for linkage in 267 sib pairs analyzed from 138 pedigrees.
These findings would be compatible with a common variant of the AT1
receptor imparting a small effect on blood pressure; further studies will
be needed to address this possibility.
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Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension
INSERM U36, College de France, Paris.
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P. P. van Geel, Y. M. Pinto, A. A. Voors, H. Buikema, M. Oosterga, H. J. G. M. Crijns, and W. H. van Gilst Angiotensin II Type 1 Receptor A1166C Gene Polymorphism Is Associated With an Increased Response to Angiotensin II in Human Arteries Hypertension, March 1, 2000; 35(3): 717 - 721. [Abstract] [Full Text] [PDF]
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L. Tiret, C. Mallet, O. Poirier, V. Nicaud, A. Millaire, J.-B. Bouhour, G.e. Roizes, M. Desnos, R. Dorent, K. Schwartz, et al. Lack of association between polymorphisms of eight candidate genes and idiopathic dilated cardiomyopathy: The CARDIGENE study J. Am. Coll. Cardiol., January 1, 2000; 35(1): 29 - 35. [Abstract] [Full Text] [PDF]
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 B. Andersson, I. Blange, and C. Sylven Angiotensin-II type 1 receptor gene polymorphism and long-term survival in patients with idiopathic congestive heart failure Eur J Heart Fail, December 17, 1999; 1(4): 363 - 369. [Abstract] [Full Text] [PDF]
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O. Olivieri, E. Trabetti, S. Grazioli, C. Stranieri, S. Friso, D. Girelli, C. Russo, P. F. Pignatti, G. Mansueto, and R. Corrocher Genetic Polymorphisms of the Renin-Angiotensin System and Atheromatous Renal Artery Stenosis Hypertension, November 1, 1999; 34(5): 1097 - 1100. [Abstract] [Full Text] [PDF]
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S. Cheng, M. A. Grow, C. Pallaud, W. Klitz, H. A. Erlich, S. Visvikis, J. J. Chen, C. R. Pullinger, M. J. Malloy, G. Siest, et al. A Multilocus Genotyping Assay for Candidate Markers of Cardiovascular Disease Risk Genome Res., October 1, 1999; 9(10): 936 - 949. [Abstract] [Full Text]
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F. A. Wright, D. T. O'Connor, E. Roberts, G. Kutey, C. C. Berry, L. U. Yoneda, D. Timberlake, and G. Schlager Genome Scan for Blood Pressure Loci in Mice Hypertension, October 1, 1999; 34(4): 625 - 630. [Abstract] [Full Text] [PDF]
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K. F. Hilgers, M. R. W. Langenfeld, M. Schlaich, R. Veelken, and R. E. Schmieder 1166 A/C Polymorphism of the Angiotensin II Type 1 Receptor Gene and the Response to Short-Term Infusion of Angiotensin II Circulation, September 28, 1999; 100(13): 1394 - 1399. [Abstract] [Full Text] [PDF]
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N. D. L. Fisher, S. Hurwitz, C. Ferri, X. Jeunemaitre, N. K. Hollenberg, and G. H. Williams Altered Adrenal Sensitivity to Angiotensin II in Low-Renin Essential Hypertension Hypertension, September 1, 1999; 34(3): 388 - 394. [Abstract] [Full Text] [PDF]
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F. Paillard, D. Chansel, E. Brand, A. Benetos, F. Thomas, S. Czekalski, R. Ardaillou, and F. Soubrier Genotype-Phenotype Relationships for the Renin-Angiotensin-Aldosterone System in a Normal Population Hypertension, September 1, 1999; 34(3): 423 - 429. [Abstract] [Full Text] [PDF]
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 A. Anvari, Z. Turel, A. Schmidt, N. Yilmaz, G. Mayer, K. Huber, E. Schuster, and M. Gottsauner-Wolf Angiotensin-converting enzyme and angiotensin II receptor 1 polymorphism in coronary disease and malignant ventricular arrhythmias Cardiovasc Res, September 1, 1999; 43(4): 879 - 883. [Abstract] [Full Text] [PDF]
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R. J. van SUYLEN, E. F. WOUTERS, H. J. PENNINGS, E. C. CHERIEX, P. E. van POL, A. W. AMBERGEN, A.-M. VERMELIS, and M. J. DAEMEN The DD Genotype of the Angiotensin Converting Enzyme Gene Is Negatively Associated with Right Ventricular Hypertrophy In Male Patients with Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., June 1, 1999; 159(6): 1791 - 1795. [Abstract] [Full Text]
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K. Kainulainen, M. Perola, J. Terwilliger, J. Kaprio, M. Koskenvuo, A.-C. Syvanen, E. Vartiainen, L. Peltonen, and K. Kontula Evidence for Involvement of the Type 1 Angiotensin II Receptor Locus in Essential Hypertension Hypertension, March 1, 1999; 33(3): 844 - 849. [Abstract] [Full Text] [PDF]
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G. I. Rice, C. A. Foy, and P. J. Grant Angiotensin converting enzyme and angiotensin II type 1-receptor gene polymorphisms and risk of ischaemic heart disease Cardiovasc Res, March 1, 1999; 41(3): 746 - 753. [Abstract] [Full Text] [PDF]
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C. H. Gelband, P. Y. Reaves, J. Evans, H. Wang, M. J. Katovich, and M. K. Raizada Angiotensin II Type 1 Receptor Antisense Gene Therapy Prevents Altered Renal Vascular Calcium Homeostasis in Hypertension Hypertension, January 1, 1999; 33(1): 360 - 365. [Abstract] [Full Text] [PDF]
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A. P. R. M. Osterop, M. J. M. Kofflard, L. A. Sandkuijl, F. J. t. Cate, R. Krams, M. A. D. H. Schalekamp, and A. H. J. Danser AT1 Receptor A/C1166 Polymorphism Contributes to Cardiac Hypertrophy in Subjects With Hypertrophic Cardiomyopathy Hypertension, November 1, 1998; 32(5): 825 - 830. [Abstract] [Full Text] [PDF]
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R. Alvarez, J. R Reguero, A. Batalla, G. Iglesias-Cubero, A. Cortina, V. Alvarez, and E. Coto Angiotensin-converting enzyme and angiotensin II receptor 1 polymorphisms: association with early coronary disease Cardiovasc Res, November 1, 1998; 40(2): 375 - 379. [Abstract] [Full Text] [PDF]
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X. Girerd, O. Hanon, J. J. Mourad, P. Boutouyrie, S. Laurent, and X. Jeunemaitre Lack of Association Between Renin-Angiotensin System, Gene Polymorphisms, and Wall Thickness of the Radial and Carotid Arteries Hypertension, September 1, 1998; 32(3): 579 - 583. [Abstract] [Full Text] [PDF]
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E. Brand, N. Chatelain, P. Mulatero, I. Fery, K. Curnow, X. Jeunemaitre, P. Corvol, L. Pascoe, and F. Soubrier Structural Analysis and Evaluation of the Aldosterone Synthase Gene in Hypertension Hypertension, August 1, 1998; 32(2): 198 - 204. [Abstract] [Full Text] [PDF]
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Y. Miyamoto, Y. Saito, N. Kajiyama, M. Yoshimura, Y. Shimasaki, M. Nakayama, S. Kamitani, M. Harada, M. Ishikawa, K. Kuwahara, et al. Endothelial Nitric Oxide Synthase Gene Is Positively Associated With Essential Hypertension Hypertension, July 1, 1998; 32(1): 3 - 8. [Abstract] [Full Text] [PDF]
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 B G MARSHALL and R J SHAW Association between angiotensin II receptor gene polymorphism and serum angiotensin converting enzyme (SACE) activity in patients with sarcoidosis Thorax, June 1, 1998; 53(6): 439 - 440. [Full Text]
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Y. Takemoto, M. Sakatani, S. Takami, T. Tachibana, J. Higaki, T. Ogihara, T. Miki, T. Katsuya, T. Tsuchiyama, A. Yoshida, et al. Association between angiotensin II receptor gene polymorphism and serum angiotensin converting enzyme (SACE) activity in patients with sarcoidosis Thorax, June 1, 1998; 53(6): 459 - 462. [Abstract] [Full Text]
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M. Fornage, C. I. Amos, S. Kardia, C. F. Sing, S. T. Turner, and E. Boerwinkle Variation in the Region of the Angiotensin-Converting Enzyme Gene Influences Interindividual Differences in Blood Pressure Levels in Young White Males Circulation, May 19, 1998; 97(18): 1773 - 1779. [Abstract] [Full Text] [PDF]
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E. Brand, N. Chatelain, B. Keavney, M. Caulfield, L. Citterio, J. Connell, D. Grobbee, S. Schmidt, H. Schunkert, H. Schuster, et al. Evaluation of the Angiotensinogen Locus in Human Essential Hypertension : A European Study Hypertension, March 1, 1998; 31(3): 725 - 729. [Abstract] [Full Text] [PDF]
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 D. Lu, H. Yang, and M. K. Raizada Attenuation of ANG II actions by adenovirus delivery of AT1 receptor antisense in neurons and SMC Am J Physiol Heart Circ Physiol, February 1, 1998; 274(2): H719 - H727. [Abstract] [Full Text] [PDF]
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 P. Corvol and X. Jeunemaitre Molecular Genetics of Human Hypertension: Role of Angiotensinogen Endocr. Rev., October 1, 1997; 18(5): 662 - 677. [Abstract] [Full Text]
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D. Lu, M. K. Raizada, S. Iyer, P. Reaves, H. Yang, and M. J. Katovich Losartan Versus Gene Therapy : Chronic Control of High Blood Pressure in Spontaneously Hypertensive Rats Hypertension, September 1, 1997; 30(3): 363 - 370. [Abstract] [Full Text]
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 E. Davies, A. Bonnardeaux, P.-F. Plouin, P. Corvol, and E. Clauser Somatic Mutations of the Angiotensin II (AT1) Receptor Gene are Not Present in Aldosterone-Producing Adenoma J. Clin. Endocrinol. Metab., February 1, 1997; 82(2): 611 - 615. [Abstract] [Full Text] [PDF]
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M. Castellano, M. L. Muiesan, M. Beschi, D. Rizzoni, A. Cinelli, M. Salvetti, G. Pasini, E. Porteri, G. Bettoni, R. Zulli, et al. Angiotensin II Type 1 Receptor A/C1166 Polymorphism: Relationships With Blood Pressure and Cardiovascular Structure Hypertension, December 1, 1996; 28(6): 1076 - 1080. [Abstract] [Full Text]
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A. Benetos, F. Cambien, S. Gautier, S. Ricard, M. Safar, S. Laurent, P. Lacolley, O. Poirier, J. Topouchian, and R. Asmar Influence of the Angiotensin II Type 1 Receptor Gene Polymorphism on the Effects of Perindopril and Nitrendipine on Arterial Stiffness in Hypertensive Individuals Hypertension, December 1, 1996; 28(6): 1081 - 1084. [Abstract] [Full Text]
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A. Benetos, S. Gautier, S. Ricard, J. Topouchian, R. Asmar, O. Poirier, E. Larosa, L. Guize, M. Safar, F. Soubrier, et al. Influence of Angiotensin-Converting Enzyme and Angiotensin II Type 1 Receptor Gene Polymorphisms on Aortic Stiffness in Normotensive and Hypertensive Patients Circulation, August 15, 1996; 94(4): 698 - 703. [Abstract] [Full Text]
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 T. L. Goodfriend, M. E. Elliott, and K. J. Catt Angiotensin Receptors and Their Antagonists N. Engl. J. Med., June 20, 1996; 334(25): 1649 - 1655. [Full Text] [PDF]
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R. F. Badenhop, X. L. Wang, and D. E.L. Wilcken Association Between an Angiotensinogen Microsatellite Marker in Children and Coronary Events in Their Grandparents Circulation, June 15, 1996; 93(12): 2092 - 2096. [Abstract] [Full Text]
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