Hypertension, Vol 24, 183-188, Copyright © 1994 by American Heart Association
JS Li, R Lariviere and EL Schiffrin
We have previously shown that the endothelin content in arteries of
deoxycorticosterone acetate (DOCA)-salt hypertensive rats is increased. We
designed this study to examine, using the new orally active nonselective
endothelin receptor antagonist bosentan, whether this increase in vascular
endothelin may contribute to elevated blood pressure and vascular
hypertrophy in DOCA-salt hypertensive rats. Rats received bosentan (100
mg/kg body wt per day) for 3 weeks mixed with their food. Systolic blood
pressure of DOCA-salt hypertensive rats rose to 197 +/- 5 mm Hg, and that
of bosentan-treated DOCA-salt hypertensive rats was 177 +/- 4 mm Hg (P <
.01). Mesenteric resistance arteries were studied on a wire myograph. The
media width, ratio of media width to lumen diameter, and cross-sectional
area of the media of resistance arteries of bosentan-treated DOCA-salt
hypertensive rats were significantly smaller than those of untreated
DOCA-salt hypertensive rats. The lumen diameter and cross-sectional area of
the media of vessels of bosentan-treated rats were not different from those
of uninephrectomized control rats. Vasoconstrictor responses, which were
altered in DOCA-salt hypertensive rats, approached control in the
bosentan-treated rats. We conclude that these results with a nonselective
endothelin receptor antagonist may suggest a role for endothelin in the
elevation of blood pressure and vascular hypertrophy and remodeling in
DOCA-salt hypertensive rats.
ARTICLES
Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats. Evidence for a role of endothelin in vascular hypertrophy
Clinical Research Institute of Montreal, University of Montreal, Canada.
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P. Moreau, H. Takase, C. F. Kung, S. Shaw, and T. F. Luscher Blood Pressure and Vascular Effects of Endothelin Blockade in Chronic Nitric Oxide–Deficient Hypertension Hypertension, March 1, 1997; 29(3): 763 - 769. [Abstract] [Full Text]
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P. Sventek, A. Turgeon, and E. L. Schiffrin Vascular Endothelin-1 Gene Expression and Effect on Blood Pressure of Chronic ETA Endothelin Receptor Antagonism After Nitric Oxide Synthase Inhibition With L-NAME in Normal Rats Circulation, January 7, 1997; 95(1): 240 - 244. [Abstract] [Full Text]
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R. M. Touyz, J. Fareh, G. Thibault, and E. L. Schiffrin Intracellular Ca2+ Modulation by Angiotensin II and Endothelin-1 in Cardiomyocytes and Fibroblasts From Hypertrophied Hearts of Spontaneously Hypertensive Rats Hypertension, November 1, 1996; 28(5): 797 - 805. [Abstract] [Full Text]
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K. Skov, J. Fenger-Gron, and M. J. Mulvany Effects of an Angiotensin-Converting Enzyme Inhibitor, a Calcium Antagonist, and an Endothelin Receptor Antagonist on Renal Afferent Arteriolar Structure Hypertension, September 1, 1996; 28(3): 464 - 471. [Abstract] [Full Text]
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J.-S. Li, L. Y. Deng, K. Grove, C. F. Deschepper, and E. L. Schiffrin Comparison of Effect of Endothelin Antagonism and Angiotensin-Converting Enzyme Inhibition on Blood Pressure and Vascular Structure in Spontaneously Hypertensive Rats Treated With N{omega}-Nitro-L-Arginine Methyl Ester: Correlation With Topography of Vascular Endothelin-1 Gene Expression Hypertension, August 1, 1996; 28(2): 188 - 195. [Abstract] [Full Text]
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N. Bouriquet, M. Dupont, A. Herizi, A. Mimran, and D. Casellas Preglomerular Sudanophilia in L-NAME Hypertensive Rats : Involvement of Endothelin Hypertension, March 1, 1996; 27(3): 382 - 391. [Abstract] [Full Text]
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J.-M. Chillon, D. D. Heistad, and G. L. Baumbach Effects of Endothelin Receptor Inhibition on Cerebral Arterioles in Hypertensive Rats Hypertension, March 1, 1996; 27(3): 794 - 798. [Abstract] [Full Text]
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P. Sventek, J.-S. Li, K. Grove, C. F. Deschepper, and E. L. Schiffrin Vascular Structure and Expression of Endothelin-1 Gene in L-NAME–Treated Spontaneously Hypertensive Rats Hypertension, January 1, 1996; 27(1): 49 - 55. [Abstract] [Full Text]
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C. E. Whitworth, M. M. Veniant, J. D. Firth, A. D. Cumming, and J. J. Mullins Endothelin in the Kidney in Malignant Phase Hypertension Hypertension, December 1, 1995; 26(6): 925 - 931. [Abstract] [Full Text]
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E. L. Schiffrin Endothelin: Potential Role in Hypertension and Vascular Hypertrophy Hypertension, June 1, 1995; 25(6): 1135 - 1143. [Abstract] [Full Text]
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J. E. Bird, S. Moreland, T. L. Waldron, and J. R. Powell Antihypertensive Effects of a Novel Endothelin-A Receptor Antagonist in Rats Hypertension, June 1, 1995; 25(6): 1191 - 1195. [Abstract] [Full Text]
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J.-S. Li and E. L. Schiffrin Effect of Chronic Treatment of Adult Spontaneously Hypertensive Rats With an Endothelin Receptor Antagonist Hypertension, April 1, 1995; 25(4): 495 - 500. [Abstract] [Full Text]
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E. L. Schiffrin, R. Lariviere, J. S. Li, P. Sventek, and R. M. Touyz Deoxycorticosterone Acetate Plus Salt Induces Overexpression of Vascular Endothelin-1 and Severe Vascular Hypertrophy in Spontaneously Hypertensive Rats Hypertension, April 1, 1995; 25(4): 769 - 773. [Abstract] [Full Text]
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P. Quehenberger, M. Exner, R. Sunder-Plassmann, K. Ruzicka, C. Bieglmayer, G. Endler, C. Muellner, W. Speiser, and O. Wagner Leptin Induces Endothelin-1 in Endothelial Cells In Vitro Circ. Res., April 5, 2002; 90(6): 711 - 718. [Abstract] [Full Text] [PDF]
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