Hypertension, Vol 24, 301-308, Copyright © 1994 by American Heart Association
H Norrelund, KL Christensen, NJ Samani, P Kimber, MJ Mulvany and N Korsgaard
The kidney is probably critically involved in the development of essential
hypertension, as in many genetic models of hypertension. We have
investigated whether a narrowed renal afferent arteriole is involved in the
pathogenesis of hypertension in spontaneously hypertensive rats. Systolic
blood pressure of 37 F2 generation spontaneously hypertensive
rats/Wistar-Kyoto rats was measured at age 7 weeks. The right kidney was
removed, and lumen diameter and media cross- sectional area of the afferent
arterioles were measured after having been fixed while relaxed and under a
transmural pressure of 100 mm Hg. The uninephrectomized rats continued
until age 23 weeks, when mean blood pressure was measured. Mean blood
pressure at 23 weeks was negatively correlated with lumen diameter at 7
weeks. Quartile analysis based on lumen diameter at 7 weeks showed that
compared with rats in the top lumen diameter quartile, rats in the bottom
lumen diameter quartile had a reduced media cross-sectional area at 7 weeks
(17%), the same systolic blood pressure at 7 weeks, and an increased (16%)
mean blood pressure at 23 weeks. We conclude that in spontaneously
hypertensive rats a narrowed lumen of distal afferent arterioles at 7 weeks
contributes to later development of increased blood pressure. This reduced
lumen could be caused by inhibited renal afferent arteriole growth.
ARTICLES
Early narrowed afferent arteriole is a contributor to the development of hypertension
Danish Biomembrane Research Centre, Aarhus University, Denmark.
This article has been cited by other articles:
 |
|
 |
|
  G. Liew, J. J. Wang, P. Mitchell, and T. Y. Wong Retinal Vascular Imaging: A New Tool in Microvascular Disease Research Circ Cardiovasc Imaging, September 1, 2008; 1(2): 156 - 161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Wang, E. Rochtchina, G. Liew, A. G. Tan, T. Y. Wong, S. R. Leeder, W. Smith, A. Shankar, and P. Mitchell The Long-term Relation among Retinal Arteriolar Narrowing, Blood Pressure, and Incident Severe Hypertension Am. J. Epidemiol., July 1, 2008; 168(1): 80 - 88. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Cheng, C. Daskalakis, and B. Falkner Original Research: Capillary rarefaction in treated and untreated hypertensive subjects Therapeutic Advances in Cardiovascular Disease, April 1, 2008; 2(2): 79 - 88. [Abstract] [PDF]
|
|
|
|
 |
|
 B. Kestenbaum, K. D. Rudser, I. H. de Boer, C. A. Peralta, L. F. Fried, M. G. Shlipak, W. Palmas, C. Stehman-Breen, and D. S. Siscovick Differences in Kidney Function and Incident Hypertension: The Multi-Ethnic Study of Atherosclerosis Ann Intern Med, April 1, 2008; 148(7): 501 - 508. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Liew, J. J. Wang, B. B. Duncan, R. Klein, A. R. Sharrett, F. Brancati, H.-C. Yeh, P. Mitchell, T. Y. Wong, and for the Atherosclerosis Risk in Communities Study Low Birthweight Is Associated With Narrower Arterioles in Adults Hypertension, April 1, 2008; 51(4): 933 - 938. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Heximer and M. Husain A Candidate Hypertension Gene: Will SPON1 Hold Salt and Water? Circ. Res., April 13, 2007; 100(7): 940 - 942. [Full Text] [PDF]
|
|
|
|
|
|
J.-R. Clemitson, R. J. Dixon, S. Haines, A. J. Bingham, B. R. Patel, L. Hall, M. Lo, J. Sassard, F. J. Charchar, and N. J. Samani Genetic Dissection of a Blood Pressure Quantitative Trait Locus on Rat Chromosome 1 and Gene Expression Analysis Identifies SPON1 As a Novel Candidate Hypertension Gene Circ. Res., April 13, 2007; 100(7): 992 - 999. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.D. Crowley, S.B. Gurley, M.J. Herrera, P. Ruiz, R. Griffiths, A.P. Kumar, H.-S. Kim, O. Smithies, T.H. Le, T.M. Coffman, et al. Role of Renal Angiotensin II Type 1 Receptors in the Genesis of Hypertension: Guyton Revisited: Angiotensin II Causes Hypertension and Cardiac Hypertrophy through Its Receptors in the Kidney. Proc Natl Acad Sci U S A 103: 17985-17990, 2006 J. Am. Soc. Nephrol., February 1, 2007; 18(2): 356 - 363. [Full Text] [PDF]
|
|
|
|
|
|
W. J. Welch, T. Chabrashvili, G. Solis, Y. Chen, P. S. Gill, S. Aslam, X. Wang, H. Ji, K. Sandberg, P. Jose, et al. Role of Extracellular Superoxide Dismutase in the Mouse Angiotensin Slow Pressor Response Hypertension, November 1, 2006; 48(5): 934 - 941. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. C. B. B. Taarnhoj, M. Larsen, B. Sander, K. O. Kyvik, L. Kessel, J. L. Hougaard, and T. I. A. Sorensen Heritability of retinal vessel diameters and blood pressure: a twin study. Invest. Ophthalmol. Vis. Sci., August 1, 2006; 47(8): 3539 - 3544. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Briones, F. E. Xavier, S. M. Arribas, M. C. Gonzalez, L. V. Rossoni, M. J. Alonso, and M. Salaices Alterations in structure and mechanics of resistance arteries from ouabain-induced hypertensive rats Am J Physiol Heart Circ Physiol, July 1, 2006; 291(1): H193 - H201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Wang and T. Y. Wong Genetic Determinants of Retinal Vascular Caliber: Additional Insights Into Hypertension Pathogenesis Hypertension, April 1, 2006; 47(4): 644 - 645. [Full Text] [PDF]
|
|
|
|
 |
|
 K. Skov, J. K. Madsen, H. E. Hansen, L. Zagato, E. Frandsen, G. Bianchi, and M. J. Mulvany Renal Haemodynamics are not Related to Genotypes in Offspring of Parents with Essential Hypertension Journal of Renin-Angiotensin-Aldosterone System, March 1, 2006; 7(1): 47 - 55. [Abstract] [PDF]
|
|
|
|
|
|
M. K. Ikram, J. C.M. Witteman, J. R. Vingerling, M. M.B. Breteler, A. Hofman, and P. T.V.M. de Jong Retinal Vessel Diameters and Risk of Hypertension: The Rotterdam Study Hypertension, February 1, 2006; 47(2): 189 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Wilcox Oxidative stress and nitric oxide deficiency in the kidney: a critical link to hypertension? Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2005; 289(4): R913 - R935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Crowley, S. Gurley, M. Oliverio, A. Pazmino, R Griffiths, P. Flannery, R. Spurney, H-S Kim, O Smithies, T. Le, et al. Is the Kidney Always the Cause of Hypertension?: Distinct Roles for the Kidney and Systemic Tissues in Blood Pressure Regulation by the Renin-Angiotensin System. J Clin Invest 115: 1092-1099, 2005 J. Am. Soc. Nephrol., June 1, 2005; 16(6): 1525 - 1532. [Full Text] [PDF]
|
|
|
|
 |
|
 O. Grisk Sympatho-renal interactions in the determination of arterial pressure: role in hypertension Exp Physiol, March 1, 2005; 90(2): 183 - 187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Smith, J. J. Wang, T. Y. Wong, E. Rochtchina, R. Klein, S. R. Leeder, and P. Mitchell Retinal Arteriolar Narrowing Is Associated With 5-Year Incident Severe Hypertension: The Blue Mountains Eye Study Hypertension, October 1, 2004; 44(4): 442 - 447. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Y. Wong, A. Shankar, R. Klein, B. E K Klein, and L. D Hubbard Prospective cohort study of retinal vessel diameters and risk of hypertension BMJ, July 10, 2004; 329(7457): 79. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Y. Wong, R. Klein, A. R. Sharrett, B. B. Duncan, D. J. Couper, B. E.K. Klein, L. D. Hubbard, F. J. Nieto, and for the Atherosclerosis Risk in Communities Study Retinal Arteriolar Diameter and Risk for Hypertension Ann Intern Med, February 17, 2004; 140(4): 248 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Wang, Y. Chen, T. Chabrashvili, S. Aslam, L. J. Borrego Conde, J. G. Umans, and C. S. Wilcox Role of Oxidative Stress in Endothelial Dysfunction and Enhanced Responses to Angiotensin II of Afferent Arterioles from Rabbits Infused with Angiotensin II J. Am. Soc. Nephrol., November 1, 2003; 14(11): 2783 - 2789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ritz and V. Haxsen Angiotensin II and Oxidative Stress: An Unholy Alliance J. Am. Soc. Nephrol., November 1, 2003; 14(11): 2985 - 2987. [Full Text] [PDF]
|
|
|
|
|
|
O. Grisk, H.-J. Rose, G. Lorenz, and R. Rettig Sympathetic-renal interaction in chronic arterial pressure control Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R441 - R450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Johnson, J. Herrera-Acosta, G. F. Schreiner, and B. Rodriguez-Iturbe Subtle Acquired Renal Injury as a Mechanism of Salt-Sensitive Hypertension N. Engl. J. Med., March 21, 2002; 346(12): 913 - 923. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yamamoto, Y. Tomura, H. Tanaka, and F. Kajiya In vivo visualization of characteristics of renal microcirculation in hypertensive and diabetic rats Am J Physiol Renal Physiol, September 1, 2001; 281(3): F571 - F577. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Salomonsson and W. J. Arendshorst Norepinephrine-induced calcium signaling pathways in afferent arterioles of genetically hypertensive rats Am J Physiol Renal Physiol, August 1, 2001; 281(2): F264 - F272. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B.I. Levy, G. Ambrosio, A.R. Pries, and H.A.J. Struijker-Boudier Microcirculation in Hypertension: A New Target for Treatment? Circulation, August 1, 2001; 104(6): 735 - 740. [Full Text] [PDF]
|
|
|
|
|
|
K. Skov, S. Mogensen, and M. J Mulvany Persistent effect of treatment with candesartan cilexetil on blood pressure in spontaneously hypertensive rats Journal of Renin-Angiotensin-Aldosterone System, March 1, 2001; 2(1_suppl): S91 - S94. [Abstract] [PDF]
|
|
|
|
|
|
W. P. Anderson, M. M. Kett, K. M. Stevenson, A. J. Edgley, K. M. Denton, and S. M. Fitzgerald Renovascular Hypertension : Structural Changes in the Renal Vasculature Hypertension, October 1, 2000; 36(4): 648 - 652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Iwai, M. Kinoshita, and H. Shimoike Chromosomal Mapping of Quantitative Trait Loci That Influence Renal Hemodynamic Functions Circulation, November 2, 1999; 100(18): 1923 - 1929. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zicha and J. Kunes Ontogenetic Aspects of Hypertension Development: Analysis in the Rat Physiol Rev, October 1, 1999; 79(4): 1227 - 1282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. B. Hansen, B. L. Jensen, and O. Skott Chloride Regulates Afferent Arteriolar Contraction in Response to Depolarization Hypertension, December 1, 1998; 32(6): 1066 - 1070. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. van SUYLEN, J. F. M. SMITS, and M. J. A. P. DAEMEN Pulmonary Artery Remodeling Differs in Hypoxia- and Monocrotaline-induced Pulmonary Hypertension Am. J. Respir. Crit. Care Med., May 1, 1997; 157(5): 1423 - 1428. [Abstract] [Full Text]
|
|
|
|
|
|
K. Skov, J. Fenger-Gron, and M. J. Mulvany Effects of an Angiotensin-Converting Enzyme Inhibitor, a Calcium Antagonist, and an Endothelin Receptor Antagonist on Renal Afferent Arteriolar Structure Hypertension, September 1, 1996; 28(3): 464 - 471. [Abstract] [Full Text]
|
|
|
|
|
|
K. Tamura, S. Umemura, N. Nyui, T. Yamakawa, S. Yamaguchi, T. Ishigami, S.-i. Tanaka, K. Tanimoto, N. Takagi, H. Sekihara, et al. Tissue-Specific Regulation of Angiotensinogen Gene Expression in Spontaneously Hypertensive Rats Hypertension, June 1, 1996; 27(6): 1216 - 1223. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. W. Cowley Jr and R. J. Roman The Role of the Kidney in Hypertension JAMA, May 22, 1996; 275(20): 1581 - 1589. [Abstract] [PDF]
|
|
|
|
|
|
M. Notoya, M. Nakamura, and K. Mizojiri Effects of Lisinopril on the Structure of Renal Arterioles Hypertension, March 1, 1996; 27(3): 364 - 370. [Abstract] [Full Text]
|
|
|
|
|
|
G. F. DiBona, S. Y. Jones, and L. L. Sawin Renal Sympathetic Neural Mechanisms as Intermediate Phenotype in Spontaneously Hypertensive Rats Hypertension, March 1, 1996; 27(3): 626 - 630. [Abstract] [Full Text]
|
|
|
|
|
|
A. Yao and D. H. Wang Heterogeneity of Adenovirus-Mediated Gene Transfer in Cultured Thoracic Aorta and Renal Artery of Rats Hypertension, December 1, 1995; 26(6): 1046 - 1050. [Abstract] [Full Text]
|
|
|
|
|
|
D. J. Campbell, A.-M. Duncan, A. Kladis, and S. B. Harrap Angiotensin Peptides in Spontaneously Hypertensive and Normotensive Donryu Rats Hypertension, May 1, 1995; 25(5): 928 - 934. [Abstract] [Full Text]
|
|