Hypertension, Vol 24, 317-321, Copyright © 1994 by American Heart Association
HY Qiu, D Henrion and BI Levy
Subthreshold concentrations of angiotensin II (Ang II) potentiate
agonist-induced tone in a variety of blood vessels. We measured in vivo the
mesenteric artery diameter and blood flow in 12-week-old normotensive
Wistar-Kyoto (WKY) rats (n = 20) and spontaneously hypertensive rats (SHR,
n = 20); systemic blood pressure was monitored continuously. Phenylephrine
(10 mumol/L) superfused on the exteriorized mesentery reduced arterial
diameter from 480 +/- 40 to 256 +/- 18 microns (P < .05) in WKY rats and
from 562 +/- 26 to 273 +/- 7 microns (P < .05) in SHR, whereas blood
flow was lowered by 77% in WKY rats and 76% in SHR (P < .05 in both
strains). Topical superfusion of an angiotensin-converting enzyme inhibitor
(perindoprilat, 10 and 100 mumol/L) attenuated the phenylephrine-induced
decrease in diameter and blood flow in both strains (P < .05). The Ang
II type 1 receptor blocker losartan (10 mumol/L) attenuated the
phenylephrine-induced decrease in diameter and blood flow in both strains
(P < .05). The relaxing effect of losartan was significantly accentuated
by the addition of perindoprilat (10 mumol/L) to the superfusate (P <
.05 in both strains). Systemic blood pressure was unaffected by the topical
application of phenylephrine (10 mumol/L), perindoprilat (10 or 100
mumol/L), or losartan (10 mumol/L). We conclude that phenylephrine- induced
tone impairment by angiotensin-converting enzyme inhibition and Ang II type
1 receptor blockade in vivo probably reflects the role of endogenous Ang II
in the potentiation of the adrenergic response during the control of
vascular tone. This role is identical in both normotensive and hypertensive
rats.
ARTICLES
Endogenous angiotensin II enhances phenylephrine-induced tone in hypertensive rats
Institut National de la Sante et de la Recherche Medicale (INSERM) U141, IFR Circulation, Universite Paris VII, Hopital Lariboisiere, France.
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