This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bohm, M. Articles by Erdmann, E. Search for Related Content PubMed PubMed Citation Articles by Bohm, M. Articles by Erdmann, E.

Hypertension, Vol 24, 653-662, Copyright © 1994 by American Heart Association

ARTICLES

Beta-adrenergic neuroeffector mechanisms in cardiac hypertrophy of renin transgenic rats

M Bohm, M Moll, B Schmid, M Paul, D Ganten, M Castellano and E Erdmann
Klinik III fur Innere Medizin, Universitat zu Koln, Germany.

We studied neuroeffector defects in hypertrophied myocardium of hypertensive transgenic rats harboring the mouse Ren-2d gene. In transgenic rats, epinephrine and neuropeptide Y concentrations were reduced. A heterologous desensitization of adenylyl cyclase was observed, which was accompanied by a downregulation of beta 1- adrenergic receptors, an increase of inhibitory G protein alpha- subunits, and a mildly depressed catalyst activity of adenylyl cyclase, whereas the bioactivity of stimulatory G protein alpha-subunits and beta 2-adrenergic receptors was unchanged. Desensitization of adenylyl cyclase was accompanied by a reduced positive inotropic response to isoproterenol, whereas the effect of Ca2+ was unchanged. We conclude that sympathetic neuroeffector defects occur in transgenic rats similar to those observed in human failing myocardium. These alterations occur in the stage of hypertrophy and could contribute to contractile dysfunction in later stages.

This article has been cited by other articles:

				Y. Kitagawa, D. Yamashita, H. Ito, and M. Takaki Reversible effects of isoproterenol-induced hypertrophy on in situ left ventricular function in rat hearts Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H277 - H285. [Abstract] [Full Text] [PDF]

				K. Nagata, C. Communal, C. C. Lim, M. Jain, T. M. Suter, F. R. Eberli, N. Satoh, W. S. Colucci, C. S. Apstein, and R. Liao Altered beta -adrenergic signal transduction in nonfailing hypertrophied myocytes from Dahl salt-sensitive rats Am J Physiol Heart Circ Physiol, November 1, 2000; 279(5): H2502 - H2508. [Abstract] [Full Text] [PDF]

				U. Schotten, K. Filzmaier, B. Borghardt, S. Kulka, F. Schoendube, C. Schumacher, and P. Hanrath Changes of beta -adrenergic signaling in compensated human cardiac hypertrophy depend on the underlying disease Am J Physiol Heart Circ Physiol, June 1, 2000; 278(6): H2076 - H2083. [Abstract] [Full Text] [PDF]

				N. Dzimiri Regulation of beta -Adrenoceptor Signaling in Cardiac Function and Disease Pharmacol. Rev., September 1, 1999; 51(3): 465 - 502. [Abstract] [Full Text] [PDF]

				G. Iaccarino, P. C. Dolber, R. J. Lefkowitz, and W. J. Koch ß-Adrenergic Receptor Kinase-1 Levels in Catecholamine-Induced Myocardial Hypertrophy : Regulation by ß- but not {alpha}1-Adrenergic Stimulation Hypertension, January 1, 1999; 33(1): 396 - 401. [Abstract] [Full Text] [PDF]

				M. Bohm, M. Castellano, M. Flesch, C. Maack, M. Moll, M. Paul, F. Schiffer, and O. Zolk Chamber-Specific Alterations of Norepinephrine Uptake Sites in Cardiac Hypertrophy Hypertension, November 1, 1998; 32(5): 831 - 837. [Abstract] [Full Text] [PDF]

				M. Bohm, S. Ettelbruck, M. Flesch, W. H van Gilst, A. Knorr, C. Maack, Y. M Pinto, M. Paul, A. C.H Teisman, and O. Zolk {beta}-Adrenergic signal transduction following carvedilol treatment in hypertensive cardiac hypertrophy Cardiovasc Res, October 1, 1998; 40(1): 146 - 155. [Abstract] [Full Text] [PDF]

				O. Zolk, M. Flesch, G. Nickenig, P. Schnabel, and M. Bohm Alteration of intracellular Ca2+-handling and receptor regulation in hypertensive cardiac hypertrophy: insights from Ren2-transgenic rats Cardiovasc Res, July 1, 1998; 39(1): 242 - 256. [Abstract] [Full Text] [PDF]

				G. Sitzler, O. Zolk, U. Laufs, M. Paul, and M. Bohm Vascular ß-Adrenergic Receptor Adenylyl Cyclase System From Renin-Transgenic Hypertensive Rats Hypertension, May 1, 1998; 31(5): 1157 - 1165. [Abstract] [Full Text] [PDF]

				M. Bohm, O. Zolk, M. Flesch, F. Schiffer, P. Schnabel, J.-P. Stasch, and A. Knorr Effects of Angiotensin II Type 1 Receptor Blockade and Angiotensin-Converting Enzyme Inhibition on Cardiac ß-Adrenergic Signal Transduction Hypertension, March 1, 1998; 31(3): 747 - 754. [Abstract] [Full Text] [PDF]

				P. Schnabel, T. Nohr, G. Nickenig, M. Paul, and M. Bohm {alpha}-Adrenergic Signal Transduction in Renin Transgenic Rats Hypertension, December 1, 1997; 30(6): 1356 - 1361. [Abstract] [Full Text]

				M. Flesch, F. Schiffer, O. Zolk, Y. Pinto, S. Rosenkranz, C. Hirth-Dietrich, G. Arnold, M. Paul, and M. Bohm Contractile Systolic and Diastolic Dysfunction in Renin-Induced Hypertensive Cardiomyopathy Hypertension, September 1, 1997; 30(3): 383 - 391. [Abstract] [Full Text]

				D.-J. Choi, W. J. Koch, J. J. Hunter, and H. A. Rockman Mechanism of beta -Adrenergic Receptor Desensitization in Cardiac Hypertrophy Is Increased beta -Adrenergic Receptor Kinase J. Biol. Chem., July 4, 1997; 272(27): 17223 - 17229. [Abstract] [Full Text] [PDF]

				M. Castellano and M. Bohm The Cardiac ß-Adrenoceptor–Mediated Signaling Pathway and Its Alterations in Hypertensive Heart Disease Hypertension, March 1, 1997; 29(3): 715 - 722. [Abstract] [Full Text]

				M. Bohm, M. Castellano, E. Agabiti-Rosei, M. Flesch, M. Paul, and E. Erdmann Dose-Dependent Dissociation of ACE-Inhibitor Effects on Blood Pressure, Cardiac Hypertrophy, and ß-Adrenergic Signal Transduction Circulation, November 15, 1995; 92(10): 3006 - 3013. [Abstract] [Full Text]

				C. L. Antos, N. Frey, S. O. Marx, S. Reiken, M. Gaburjakova, J. A. Richardson, A. R. Marks, and E. N. Olson Dilated Cardiomyopathy and Sudden Death Resulting From Constitutive Activation of Protein Kinase A Circ. Res., November 23, 2001; 89(11): 997 - 1004. [Abstract] [Full Text] [PDF]