This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Maheux, P. Articles by Reaven, G. M. Search for Related Content PubMed PubMed Citation Articles by Maheux, P. Articles by Reaven, G. M.

Hypertension, Vol 24, 695-698, Copyright © 1994 by American Heart Association

ARTICLES

Additive effects of obesity, hypertension, and type 2 diabetes on insulin resistance

P Maheux, J Jeppesen, WH Sheu, CB Hollenbeck, C Clinkingbeard, MS Greenfield, YD Chen and GM Reaven
Department of Medicine, Stanford University School of Medicine, Calif.

Resistance to insulin-mediated glucose disposal has been previously shown to be increased in association with obesity, high blood pressure, and non-insulin-dependent diabetes mellitus. We initiated the present study to quantify the separate effects of hypertension and non-insulin- dependent diabetes mellitus on insulin resistance in both nonobese and obese subjects. To accomplish this, 88 subjects were divided into the following five experimental groups: normal blood pressure, nonobese (n = 17); normal blood pressure, obese (n = 18); high blood pressure, nonobese (n = 18); high blood pressure, obese (n = 19); and high blood pressure, obese, non-insulin-dependent diabetes mellitus (n = 16). Plasma glucose and insulin concentrations were measured before and after a 75-g oral glucose load. Resistance to insulin-mediated glucose disposal was estimated by determining the steady-state plasma insulin and glucose concentrations during the last 30 minutes of a continuous infusion of somatostatin (5 micrograms/min), exogenous insulin (25 mU/m2 per minute), and glucose (240 mg/m2 per minute). Since the steady- state plasma insulin concentrations are similar in all subjects, the higher the steady-state plasma glucose, the more insulin resistant the individual. Nonobese subjects with normal blood pressure had the lowest plasma glucose and insulin responses and steady-state plasma glucose concentrations, and their values were significantly different from the other four groups. Obese or nonobese subjects with high blood pressure had significantly higher plasma glucose responses and steady-state plasma glucose concentrations than did their respective weight-matched control subjects.(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				C.-M. Hwu, T.-L. Liou, L.-C. Hsiao, and M.-W. Lin Prehypertension is associated with insulin resistance QJM, October 1, 2009; 102(10): 705 - 711. [Abstract] [Full Text] [PDF]

				A. Natali, E. Toschi, S. Baldeweg, D. Ciociaro, S. Favilla, L. Sacca, and E. Ferrannini Clustering of insulin resistance with vascular dysfunction and low-grade inflammation in type 2 diabetes. Diabetes, April 1, 2006; 55(4): 1133 - 1140. [Abstract] [Full Text] [PDF]

				F. Abbasi, B. W. Brown Jr, C. Lamendola, T. McLaughlin, and G. M. Reaven Relationship between obesity, insulin resistance, and coronary heart disease risk J. Am. Coll. Cardiol., September 4, 2002; 40(5): 937 - 943. [Abstract] [Full Text] [PDF]

				W.-H. Lin, K. C. Chiu, H.-M. Chang, K.-C. Lee, T.-Y. Tai, and L.-M. Chuang Molecular scanning of the human sorbin and SH3-domain-containing-1 (SORBS1) gene: positive association of the T228A polymorphism with obesity and type 2 diabetes Hum. Mol. Genet., August 1, 2001; 10(17): 1753 - 1760. [Abstract] [Full Text] [PDF]

				P. Ernsberger, T. Ishizuka, S. Liu, C. J. Farrell, D. Bedol, R. J. Koletsky, and J. E. Friedman Mechanisms of Antihyperglycemic Effects of Moxonidine in the Obese Spontaneously Hypertensive Koletsky Rat (SHROB) J. Pharmacol. Exp. Ther., January 1, 1999; 288(1): 139 - 147. [Abstract] [Full Text]

				G. Piédrola, E. Novo, J. Serrano-Gotarredona, M. L. de Teresa, and R. García-Robles Evolution of insulin resistance in coronary artery disease patients on four different pharmacological therapies Postgrad. Med. J., January 1, 1999; 75(879): 27 - 31. [Abstract] [Full Text]

				J. E. Friedman, T. Ishizuka, S. Liu, C. J. Farrell, D. Bedol, R. J. Koletsky, H.-L. Kaung, and P. Ernsberger Reduced insulin receptor signaling in the obese spontaneously hypertensive Koletsky rat Am J Physiol Endocrinol Metab, November 1, 1997; 273(5): E1014 - E1023. [Abstract] [Full Text] [PDF]

				D. S. Hardin, J. D. Hebert, T. Bayden, M. Dehart, and L. Mazur Treatment of Childhood Syndrome X Pediatrics, August 1, 1997; 100(2): e5 - e5. [Abstract] [Full Text] [PDF]