This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Suzuki, H. Articles by Zweifach, B. W. Search for Related Content PubMed PubMed Citation Articles by Suzuki, H. Articles by Zweifach, B. W.

Hypertension, Vol 24, 719-727, Copyright © 1994 by American Heart Association

ARTICLES

Impaired leukocyte-endothelial cell interaction in spontaneously hypertensive rats

H Suzuki, GW Schmid-Schonbein, M Suematsu, FA DeLano, MJ Forrest, M Miyasaka and BW Zweifach
Institute for Biomedical Engineering, University of California, San Diego, La Jolla 92093-0412.

Hypertension is associated with a progressive organ injury whose etiology remains largely speculative. An increasing database shows that activated leukocytes, while affording an important immune protection, may be a contributing factor to several of the pathogenetic features of the hypertension syndrome. The purpose of this study was to determine the extent to which the glucocorticoid pathway may be involved in the atypical kinetics of leukocytes in spontaneously hypertensive rats (SHR) compared with normotensive Wistar-Kyoto (WKY) rats. The typical venular leukocyte adhesion induced by histamine application was significantly lower in SHR, and a comparison of normalized leukocyte rolling velocity (VWBC/VRBC) showed the values to be significantly higher in SHR relative to WKY controls. This abnormal trend in adherent leukocyte numbers and in VWBC/VRBC values could be counteracted when SHR were pretreated with RU 486, a synthetic glucocorticoid inhibitor, and restored to the levels observed in WKY rats. Anti-P-selectin monoclonal antibody (PB1.3) attenuated in SHR and WKY rats the increment of adherent leukocyte numbers as well as the decrement of VWBC/VRBC value that developed under combined histamine and RU 486 superfusion. Furthermore, an anti-intercellular adhesion molecule-1 monoclonal antibody (1A29) served to attenuate the increment of adherent leukocyte number induced by a combination of histamine and RU 486 superfusion in WKY rats and SHR. The results indicate that the deficient leukocyte-endothelial cell interaction in SHR can be circumvented by a glucocorticoid inhibitor.

This article has been cited by other articles:

				A. J Rickard and M. J Young Corticosteroid receptors, macrophages and cardiovascular disease J. Mol. Endocrinol., June 1, 2009; 42(6): 449 - 459. [Abstract] [Full Text] [PDF]

				H. G. Bohlen Metalloproteinases Damage the Insulin Receptor to Cause Insulin Resistance in Spontaneously Hypertensive Rats Hypertension, August 1, 2008; 52(2): 215 - 217. [Full Text] [PDF]

				F. A. DeLano, R. Balete, and G. W. Schmid-Schonbein Control of oxidative stress in microcirculation of spontaneously hypertensive rats Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H805 - H812. [Abstract] [Full Text] [PDF]

				S. C. Schafer, T. Wallerath, E. I. Closs, C. Schmidt, P. M. Schwarz, U. Forstermann, and H.-A. Lehr Dexamethasone suppresses eNOS and CAT-1 and induces oxidative stress in mouse resistance arterioles Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H436 - H444. [Abstract] [Full Text] [PDF]

				S. Fukuda, T. Yasu, N. Kobayashi, N. Ikeda, and G. W. Schmid-Schonbein Contribution of Fluid Shear Response in Leukocytes to Hemodynamic Resistance in the Spontaneously Hypertensive Rat Circ. Res., July 9, 2004; 95(1): 100 - 108. [Abstract] [Full Text] [PDF]

				G. E. Callera, A. C. Montezano, R. M. Touyz, T. M.T. Zorn, M. H. C. Carvalho, Z. B. Fortes, D. Nigro, E. L. Schiffrin, and R. C. Tostes ETA Receptor Mediates Altered Leukocyte-Endothelial Cell Interaction and Adhesion Molecules Expression in DOCA-Salt Rats Hypertension, April 1, 2004; 43(4): 872 - 879. [Abstract] [Full Text] [PDF]

				M. Galinanes and A. G Fowler Role of clinical pathologies in myocardial injury following ischaemia and reperfusion Cardiovasc Res, February 15, 2004; 61(3): 512 - 521. [Abstract] [Full Text] [PDF]

				J. Y.H. Chan, L.-L. Wang, K. L.H. Wu, and S. H.H. Chan Reduced Functional Expression and Molecular Synthesis of Inducible Nitric Oxide Synthase in Rostral Ventrolateral Medulla of Spontaneously Hypertensive Rats Circulation, October 2, 2001; 104(14): 1676 - 1681. [Abstract] [Full Text] [PDF]

				G. Caimi, R. L. Presti, C. Carollo, M. Musso, F. Porretto, B. Canino, A. Catania, and G. Cerasola Polymorphonuclear Integrins, Membrane Fluidity, and Cytosolic Ca2+ Content After Activation in Essential Hypertension Hypertension, November 1, 2000; 36(5): 813 - 817. [Abstract] [Full Text] [PDF]

				A. Tsujikawa, J. Kiryu, K. Yamashiro, A. Nonaka, K. Nishijima, Y. Honda, and Y. Ogura Interactions Between Blood Cells and Retinal Endothelium in Endotoxic Sepsis Hypertension, August 1, 2000; 36(2): 250 - 258. [Abstract] [Full Text] [PDF]

				T. Yasu, G. W. Schmid-Schonbein, B. Cotter, and A. N. DeMaria Flow dynamics of QW7437, a new dodecafluoropentane ultrasound contrast agent, in the microcirculation: Microvascular mechanisms for persistent tissue echo enhancement J. Am. Coll. Cardiol., August 1, 1999; 34(2): 578 - 586. [Abstract] [Full Text] [PDF]

				I. Kurose, R. Wolf, W. Cerwinka, and D. N. Granger Microvascular Responses to Ischemia/Reperfusion in Normotensive and Hypertensive Rats Hypertension, August 1, 1999; 34(2): 212 - 216. [Abstract] [Full Text] [PDF]

				H. Suzuki, F. A. Delano, N. Jamshidi, D. Katz, M. Mori, K. Kosaki, R. A. Gottlieb, H. Ishii, and G. W. Schmid-Schonbein Enhanced DNA fragmentation in the thymus of spontaneously hypertensive rats Am J Physiol Heart Circ Physiol, June 1, 1999; 276(6): H2135 - H2140. [Abstract] [Full Text] [PDF]

				C. Bernard, R. Merval, B. Esposito, and A. Tedgui Resistance to Endotoxin Shock in Spontaneously Hypertensive Rats Hypertension, June 1, 1998; 31(6): 1350 - 1356. [Abstract] [Full Text] [PDF]

				S. Komatsu, J. Panes, J. M. Russell, D. C. Anderson, V. R. Muzykantov, M. Miyasaka, and D. N. Granger Effects of Chronic Arterial Hypertension on Constitutive and Induced Intercellular Adhesion Molecule-1 Expression In Vivo Hypertension, February 1, 1997; 29(2): 683 - 689. [Abstract] [Full Text]

				H. Suzuki, B. W. Zweifach, and G. W. Schmid-Schonbein Glucocorticoid Modulates Vasodilator Response of Mesenteric Arterioles in Spontaneously Hypertensive Rats Hypertension, January 1, 1996; 27(1): 114 - 118. [Abstract] [Full Text]

				H. Suzuki, B. W. Zweifach, and G. W. Schmid-Schonbein Vasodilator Response of Mesenteric Arterioles to Histamine in Spontaneously Hypertensive Rats Hypertension, September 1, 1995; 26(3): 397 - 400. [Abstract] [Full Text]

				H. Suzuki, A. Swei, B. W. Zweifach, and G. W. Schmid-Schonbein In Vivo Evidence for Microvascular Oxidative Stress in Spontaneously Hypertensive Rats : Hydroethidine Microfluorography Hypertension, May 1, 1995; 25(5): 1083 - 1089. [Abstract] [Full Text]

				B. Rodriguez-Iturbe, Y. Quiroz, M. Nava, L. Bonet, M. Chavez, J. Herrera-Acosta, R. J. Johnson, and H. A. Pons Reduction of renal immune cell infiltration results in blood pressure control in genetically hypertensive rats Am J Physiol Renal Physiol, February 1, 2002; 282(2): F191 - F201. [Abstract] [Full Text] [PDF]